1.14.19.17: sphingolipid 4-desaturase

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For detailed information about sphingolipid 4-desaturase, go to the full flat file.

Word Map on EC 1.14.19.17

1.14.19.17

sphingolipids

german

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gnhies98

dhcers

fenretinide

drug development

pharmacology

Reaction

+ 2 ferrocytochrome b5 +

+ 2 H+ =

+ 2 ferricytochrome b5 + 2 H2O

Synonyms

degenerative spermatocyte desaturase, DegS, Degs1, DEGS2, dehydroceramide desaturase, DELTA4 desaturase, DELTA4DES, DES-1, DES1, DES2, DHCD, dihydroceramide C4-desaturase, dihydroceramide DELTA4-(E)-desaturase, dihydroceramide DELTA4-desaturase, dihydroceramide DELTA4-desaturase 1, dihydroceramide desaturase, dihydroceramide desaturase 1, dihydroceramide desaturase 2, dihydroceramide desaturase-1, dihydroceramide-desaturase-1, drosophila degenerative spermatocyte 1, drosophila degenerative spermatocyte 2, ifc, LCB DELTA4 desaturase, MDES, membrane lipid desaturase, MLD, SPBC3B8.07c, sphingolipid DELTA4-desaturase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

1.14.19.17 sphingolipid 4-desaturase

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4	Activating Compound
3117	AA Sequence
5	Application
12	Cloned(Commentary)
39	Cofactor
214	Disease/ Diagnostics
8	Expression
43	General Information
8	IC50 Value
84	Inhibitors
6	Ki Value [mM]
3	KM Value [mM]
23	Localization
5	Metals/Ions
1	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
33	Organism
6	Pathway
8	pH Optimum
5	pH Range
5	Posttranslational Modification
4	Protein Variants
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6	Reaction
32	Reference
57	Source Tissue
3	Storage Stability
46	Substrates and Products (Substrate)
2	Subunits
100	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]

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Engineering on EC 1.14.19.17 - sphingolipid 4-desaturase

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L175Q

Homo sapiens

O15121

naturally occuring mutation, the mutation is is associated with increased levels of dihydroceramides, decreased levels of cholesterol esters and decreased waist to hip ratio

744398

additional information

3 entries