1.14.19.17: sphingolipid 4-desaturase

This is an abbreviated version!
For detailed information about sphingolipid 4-desaturase, go to the full flat file.

Reaction

Synonyms

degenerative spermatocyte desaturase, DegS, Degs1, DEGS2, dehydroceramide desaturase, DELTA4 desaturase, DELTA4DES, DES-1, DES1, DES2, DHCD, dihydroceramide C4-desaturase, dihydroceramide DELTA4-(E)-desaturase, dihydroceramide DELTA4-desaturase, dihydroceramide DELTA4-desaturase 1, dihydroceramide desaturase, dihydroceramide desaturase 1, dihydroceramide desaturase 2, dihydroceramide desaturase-1, dihydroceramide-desaturase-1, drosophila degenerative spermatocyte 1, drosophila degenerative spermatocyte 2, ifc, LCB DELTA4 desaturase, MDES, membrane lipid desaturase, MLD, SPBC3B8.07c, sphingolipid DELTA4-desaturase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

                1.14.19.17 sphingolipid 4-desaturase

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Results	in table
4	Activating Compound
3117	AA Sequence
5	Application
12	Cloned(Commentary)
39	Cofactor
214	Disease/ Diagnostics
8	Expression
43	General Information
8	IC50 Value
84	Inhibitors
6	Ki Value [mM]
3	KM Value [mM]
23	Localization
5	Metals/Ions
1	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
33	Organism
6	Pathway
8	pH Optimum
5	pH Range
5	Posttranslational Modification
4	Protein Variants
1	Purification (Commentary)
6	Reaction
32	Reference
57	Source Tissue
3	Storage Stability
46	Substrates and Products (Substrate)
2	Subunits
100	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]

Natural Substrates Products

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Natural Substrates Products on EC 1.14.19.17 - sphingolipid 4-desaturase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+

a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H2O

6 entries

dihydroceramide + ferrocytochrome b5 + O2 + H+

(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O

10 entries

dihydroceramide + reduced acceptor + O2 + H+

(4E)-sphing-4-enine ceramide + acceptor + H2O

Candida albicans

-

-

734825

-

-

?

tetracosanoyl-dihydroceramide + reduced acceptor + O2 + 2 H+

?

Homo sapiens

-

-

744418

-

-

?

additional information

?

-

2 entries

a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+

a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H2O

Chlorocebus aethiops

-

-

744398

-

-

?

a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+

a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H2O

Drosophila melanogaster

Q94515

-

744686, 744398

-

-

?

a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+

a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H2O

Homo sapiens

-

-

744680, 745527

-

-

?

a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+

a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H2O

Homo sapiens

O15121

-

744398, 744686

-

-

?

a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+

a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H2O

Mus musculus

O09005

-

744398, 744686

-

-

?

a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+

a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H2O

Rattus norvegicus

Q5XIF5

-

744686

-

-

?

dihydroceramide + ferrocytochrome b5 + O2 + H+

(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O

Arabidopsis thaliana

-

-

734864

-

-

?

dihydroceramide + ferrocytochrome b5 + O2 + H+

(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O

Caenorhabditis elegans

G5EC63

-

734141

-

-

?

dihydroceramide + ferrocytochrome b5 + O2 + H+

(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O

Candida albicans

Q5AJX2

-

734141

-

-

?

dihydroceramide + ferrocytochrome b5 + O2 + H+

(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O

Drosophila melanogaster

Q94515

-

734141

-

-

?

dihydroceramide + ferrocytochrome b5 + O2 + H+

(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O

Homo sapiens

O15121

-

734141

-

-

?

dihydroceramide + ferrocytochrome b5 + O2 + H+

(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O

Komagataella pastoris

-

-

734166

-

-

?

dihydroceramide + ferrocytochrome b5 + O2 + H+

(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O

Mus musculus

O09005

-

734141

-

-

?

dihydroceramide + ferrocytochrome b5 + O2 + H+

(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O

Rattus norvegicus

Q564G3

-

733429, 734602

-

-

?

dihydroceramide + ferrocytochrome b5 + O2 + H+

(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O

Rattus norvegicus

Q5XIF5

-

733428

-

-

?

dihydroceramide + ferrocytochrome b5 + O2 + H+

(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O

Schizosaccharomyces pombe

O59715

-

733853

-

-

?

additional information

?

-

Drosophila melanogaster

-

while Des1 exhibits high dihydroceramide C4-desaturase and very low C-4 hydroxylase activities, Des2, the product of the gene DEGS2 or DES2, exhibits bifunctional sphingolipid C-4 hydroxylase and C4-desaturase activities

744686

-

-

?

additional information

?

-

Drosophila melanogaster

Q94515

while Des1 exhibits high dihydroceramide C4-desaturase and very low C-4 hydroxylase activities, Des2, the product of the gene DEGS2 or DES2, exhibits bifunctional sphingolipid C-4 hydroxylase and C4-desaturase activities

744686

-

-

?