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1.14.19.17: sphingolipid 4-desaturase

This is an abbreviated version!
For detailed information about sphingolipid 4-desaturase, go to the full flat file.

Word Map on EC 1.14.19.17

Reaction

a dihydroceramide
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
a (4E)-sphing-4-enine ceramide
+ 2 ferricytochrome b5 + 2 H2O

Synonyms

degenerative spermatocyte desaturase, DegS, Degs1, DEGS2, dehydroceramide desaturase, DELTA4 desaturase, DELTA4DES, DES-1, DES1, DES2, DHCD, dihydroceramide C4-desaturase, dihydroceramide DELTA4-(E)-desaturase, dihydroceramide DELTA4-desaturase, dihydroceramide DELTA4-desaturase 1, dihydroceramide desaturase, dihydroceramide desaturase 1, dihydroceramide desaturase 2, dihydroceramide desaturase-1, dihydroceramide-desaturase-1, drosophila degenerative spermatocyte 1, drosophila degenerative spermatocyte 2, ifc, LCB DELTA4 desaturase, MDES, membrane lipid desaturase, MLD, SPBC3B8.07c, sphingolipid DELTA4-desaturase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.17 sphingolipid 4-desaturase

Substrates Products

Substrates Products on EC 1.14.19.17 - sphingolipid 4-desaturase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,4-dinitrophenyl-sphinganine + reduced acceptor + O2 + H+
2,4-dinitrophenyl-sphingosine + acceptor + H2O
show the reaction diagram
-
-
-
-
?
a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+
a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
dihydroceramide + ferrocytochrome b5 + O2 + H+
(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
show the reaction diagram
dihydroceramide + reduced acceptor + O2 + H+
(4E)-sphing-4-enine ceramide + acceptor + H2O
show the reaction diagram
-
-
-
-
?
dihydrosphingomyelin + NADH + O2 + H+
?
show the reaction diagram
20% activity compared to N-octanoyl-D-erythro-C18-sphinganine
-
-
?
N-((2S,3R,6E)-1,3-dihydroxyoctadec-6-en-2-yl)-6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanamide + 2 ferrocytochrome b5 + O2 + 2 H+
N-((2S,3R,4E,6E)-1,3-dihydroxyoctadeca-4,6-dien-2-yl)-6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanamide + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
-
-
-
?
N-((2S,3R,6E)-1,3-dihydroxyoctadec-6-en-2-yl)octanamide + 2 ferrocytochrome b5 + O2 + 2 H+
N-((2S,3R,4E,6E)-1,3-dihydroxyoctadeca-4,6-dien-2-yl)octanamide + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
-
-
-
?
N-((2S,3R,6Z)-1,3-dihydroxyoctadec-6-en-2-yl)-6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanamide + 2 ferrocytochrome b5 + O2 + 2 H+
N-((2S,3R,4E,6Z)-1,3-dihydroxyoctadeca-4,6-dien-2-yl)-6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanamide + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
-
-
-
?
N-((2S,3R,6Z)-1,3-dihydroxyoctadec-6-en-2-yl)octanamide + 2 ferrocytochrome b5 + O2 + 2 H+
N-((2S,3R,4E,6Z)-1,3-dihydroxyoctadeca-4,6-dien-2-yl)octanamide + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
-
-
-
-
?
N-hexanoyl-[4,5-3H]sphinganine + NADPH + O2 + H+
?
show the reaction diagram
-
-
-
?
N-octanoyl-D-erythro-C18-sphinganine + NADH + O2 + H+
N-octanoyl-D-erythro-C18-sphingosine + NAD+ + H2O
show the reaction diagram
-
-
-
?
N-octanoyl-D-erythro-C18-sphinganine + NADPH + O2 + H+
N-octanoyl-D-erythro-C18-sphingosine + NADP+ + H2O
show the reaction diagram
-
-
-
?
N-octanoyldihydroceramide + NAD(P)H + O2 + H+
?
show the reaction diagram
-
-
-
?
N-octanoylsphinganine + ferrocytochrome b5 + O2 + 2 H+
N-octanoylsphingosine + ferricytochrome b5 + 2 H2O
show the reaction diagram
-
-
-
-
?
N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphinganine + 2 ferrocytochrome b5 + O2 + 2 H+
?
show the reaction diagram
N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphinganine + reduced acceptor + O2 + 2 H+
?
show the reaction diagram
-
-
-
-
?
tetracosanoyl-dihydroceramide + reduced acceptor + O2 + 2 H+
?
show the reaction diagram
-
-
-
-
?
additional information
?
-