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2,4-dinitrophenyl-sphinganine + reduced acceptor + O2 + H+
2,4-dinitrophenyl-sphingosine + acceptor + H2O
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a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+
a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H2O
dihydroceramide + ferrocytochrome b5 + O2 + H+
(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
dihydroceramide + reduced acceptor + O2 + H+
(4E)-sphing-4-enine ceramide + acceptor + H2O
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dihydrosphingomyelin + NADH + O2 + H+
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20% activity compared to N-octanoyl-D-erythro-C18-sphinganine
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N-((2S,3R,6E)-1,3-dihydroxyoctadec-6-en-2-yl)-6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanamide + 2 ferrocytochrome b5 + O2 + 2 H+
N-((2S,3R,4E,6E)-1,3-dihydroxyoctadeca-4,6-dien-2-yl)-6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanamide + 2 ferricytochrome b5 + 2 H2O
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N-((2S,3R,6E)-1,3-dihydroxyoctadec-6-en-2-yl)octanamide + 2 ferrocytochrome b5 + O2 + 2 H+
N-((2S,3R,4E,6E)-1,3-dihydroxyoctadeca-4,6-dien-2-yl)octanamide + 2 ferricytochrome b5 + 2 H2O
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N-((2S,3R,6Z)-1,3-dihydroxyoctadec-6-en-2-yl)-6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanamide + 2 ferrocytochrome b5 + O2 + 2 H+
N-((2S,3R,4E,6Z)-1,3-dihydroxyoctadeca-4,6-dien-2-yl)-6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanamide + 2 ferricytochrome b5 + 2 H2O
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N-((2S,3R,6Z)-1,3-dihydroxyoctadec-6-en-2-yl)octanamide + 2 ferrocytochrome b5 + O2 + 2 H+
N-((2S,3R,4E,6Z)-1,3-dihydroxyoctadeca-4,6-dien-2-yl)octanamide + 2 ferricytochrome b5 + 2 H2O
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N-hexanoyl-[4,5-3H]sphinganine + NADPH + O2 + H+
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N-octanoyl-D-erythro-C18-sphinganine + NADH + O2 + H+
N-octanoyl-D-erythro-C18-sphingosine + NAD+ + H2O
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?
N-octanoyl-D-erythro-C18-sphinganine + NADPH + O2 + H+
N-octanoyl-D-erythro-C18-sphingosine + NADP+ + H2O
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N-octanoyldihydroceramide + NAD(P)H + O2 + H+
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N-octanoylsphinganine + ferrocytochrome b5 + O2 + 2 H+
N-octanoylsphingosine + ferricytochrome b5 + 2 H2O
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N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphinganine + 2 ferrocytochrome b5 + O2 + 2 H+
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N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphinganine + reduced acceptor + O2 + 2 H+
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tetracosanoyl-dihydroceramide + reduced acceptor + O2 + 2 H+
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additional information
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a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+
a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H2O
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a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+
a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H2O
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a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+
a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H2O
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a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+
a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H2O
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a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+
a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H2O
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a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+
a (4E)-sphing-4-enine ceramide + 2 ferricytochrome b5 + 2 H2O
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dihydroceramide + ferrocytochrome b5 + O2 + H+
(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
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dihydroceramide + ferrocytochrome b5 + O2 + H+
(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
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dihydroceramide + ferrocytochrome b5 + O2 + H+
(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
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dihydroceramide + ferrocytochrome b5 + O2 + H+
(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
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dihydroceramide + ferrocytochrome b5 + O2 + H+
(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
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dihydroceramide + ferrocytochrome b5 + O2 + H+
(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
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dihydroceramide + ferrocytochrome b5 + O2 + H+
(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
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dihydroceramide + ferrocytochrome b5 + O2 + H+
(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
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dihydroceramide + ferrocytochrome b5 + O2 + H+
(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
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dihydroceramide + ferrocytochrome b5 + O2 + H+
(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
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N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphinganine + 2 ferrocytochrome b5 + O2 + 2 H+
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N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphinganine + 2 ferrocytochrome b5 + O2 + 2 H+
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fluorescence-lebeld substrate
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additional information
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while Des1 exhibits high dihydroceramide C4-desaturase and very low C-4 hydroxylase activities, Des2, the product of the gene DEGS2 or DES2, exhibits bifunctional sphingolipid C-4 hydroxylase and C4-desaturase activities
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additional information
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while Des1 exhibits high dihydroceramide C4-desaturase and very low C-4 hydroxylase activities, Des2, the product of the gene DEGS2 or DES2, exhibits bifunctional sphingolipid C-4 hydroxylase and C4-desaturase activities
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additional information
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the electron provided by NAD(P)H is sequentially transported from the cofactor to NADH-cytochrome b5 reductase, cytochrome b5, and the terminal desaturase, which reduces oxygen to water and oxidizes dihydroceramide to ceramide. Desaturation of the D-erythro-isomer by Des1 is much faster than that of the L or D-threo-isomers
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additional information
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the electron provided by NAD(P)H is sequentially transported from the cofactor to NADH-cytochrome b5 reductase, cytochrome b5, and the terminal desaturase, which reduces oxygen to water and oxidizes dihydroceramide to ceramide. Desaturation of the D-erythro-isomer by Des1 is much faster than that of the L or D-threo-isomers
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additional information
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configurational preference of dihydroceramide desaturase-1 towards DELTA6-unsaturated substrates. Establishment of an assay for Des1 activity based on the use of an immobilized DELTA6-monoene as a substrate for further click reaction of the resulting diene with a labelable dienophile, chemical synthesis of DELTA6 and DELTA4,6 sphingoid bases, substrate specificity, overview
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additional information
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the electron provided by NAD(P)H is sequentially transported from the cofactor to NADH-cytochrome b5 reductase, cytochrome b5, and the terminal desaturase, which reduces oxygen to water and oxidizes dihydroceramide to ceramide. Desaturation of the D-erythro-isomer by Des1 is much faster than that of the L or D-threo-isomers
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additional information
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the electron provided by NAD(P)H is sequentially transported from the cofactor to NADH-cytochrome b5 reductase, cytochrome b5, and the terminal desaturase, which reduces oxygen to water and oxidizes dihydroceramide to ceramide. Desaturation of the D-erythro-isomer by Des1 is much faster than that of the L or D-threo-isomers
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additional information
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no activity detected with dihydroglucosylceramide
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additional information
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the electron provided by NAD(P)H is sequentially transported from the cofactor to NADH-cytochrome b5 reductase, cytochrome b5, and the terminal desaturase, which reduces oxygen to water and oxidizes dihydroceramide to ceramide. Desaturation of the D-erythro-isomer by Des1 is much faster than that of the L or D-threo-isomers
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additional information
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the enzyme does not recognise fatty acids and trihydroxylated sphingoid long-chain bases as substrate
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additional information
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the enzyme does not recognise fatty acids and trihydroxylated sphingoid long-chain bases as substrate
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