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1.14.19.17: sphingolipid 4-desaturase

This is an abbreviated version!
For detailed information about sphingolipid 4-desaturase, go to the full flat file.

Word Map on EC 1.14.19.17

Reaction

a dihydroceramide
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
a (4E)-sphing-4-enine ceramide
+ 2 ferricytochrome b5 + 2 H2O

Synonyms

degenerative spermatocyte desaturase, DegS, Degs1, DEGS2, dehydroceramide desaturase, DELTA4 desaturase, DELTA4DES, DES-1, DES1, DES2, DHCD, dihydroceramide C4-desaturase, dihydroceramide DELTA4-(E)-desaturase, dihydroceramide DELTA4-desaturase, dihydroceramide DELTA4-desaturase 1, dihydroceramide desaturase, dihydroceramide desaturase 1, dihydroceramide desaturase 2, dihydroceramide desaturase-1, dihydroceramide-desaturase-1, drosophila degenerative spermatocyte 1, drosophila degenerative spermatocyte 2, ifc, LCB DELTA4 desaturase, MDES, membrane lipid desaturase, MLD, SPBC3B8.07c, sphingolipid DELTA4-desaturase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.17 sphingolipid 4-desaturase

Reference

Reference on EC 1.14.19.17 - sphingolipid 4-desaturase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Beauchamp, E.; Goenaga, D.; Le Bloch, J.; Catheline, D.; Legrand, P.; Rioux, V.
Myristic acid increases the activity of dihydroceramide DELTA4-desaturase 1 through its N-terminal myristoylation
Biochimie
89
1553-1561
2007
Rattus norvegicus (Q5XIF5)
Manually annotated by BRENDA team
Beauchamp, E.; Tekpli, X.; Marteil, G.; Lagadic-Gossmann, D.; Legrand, P.; Rioux, V.
N-myristoylation targets dihydroceramide DELTA4-desaturase 1 to mitochondria: Partial involvement in the apoptotic effect of myristic acid
Biochimie
91
1411-1419
2009
Rattus norvegicus (Q564G3)
Manually annotated by BRENDA team
Garton, S.; Michaelson, L.V.; Beaudoin, F.; Beale, M.H.; Napier, J.A.
The dihydroceramide desaturase is not essential for cell viability in Schizosaccharomyces pombe
FEBS Lett.
538
192-196
2003
Schizosaccharomyces pombe (O59715), Schizosaccharomyces pombe
Manually annotated by BRENDA team
Michel, C.; Van Echten-Deckert, G.; Rother, J.; Sandhoff, K.; Wang, E.; Merrill Jr., A.
Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide
J. Biol. Chem.
272
22432-22437
1997
Rattus norvegicus (Q564G3)
Manually annotated by BRENDA team
Ternes, P.; Franke, S.; Zaehringer, U.; Sperling, P.; Heinz, E.
Identification and characterization of a sphingolipid delta 4-desaturase family
J. Biol. Chem.
277
25512-25518
2002
Caenorhabditis elegans (G5EC63), Mus musculus (O09005), Mus musculus, Homo sapiens (O15121), Homo sapiens, Candida albicans (Q5AJX2), Candida albicans, Drosophila melanogaster (Q94515), Drosophila melanogaster
Manually annotated by BRENDA team
Ternes, P.; Wobbe, T.; Schwarz, M.; Albrecht, S.; Feussner, K.; Riezman, I.; Cregg, J.; Heinz, E.; Riezman, H.; Feussner, I.; Warnecke, D.
Two pathways of sphingolipid biosynthesis are separated in the yeast Pichia pastoris
J. Biol. Chem.
286
11401-11414
2011
Komagataella pastoris
Manually annotated by BRENDA team
Causeret, C.; Geeraert, L.; Van der Hoeven, G.; Mannaerts, G.; Van Veldhoven, P.
Further characterization of rat dihydroceramide desaturase: Tissue distribution, subcellular localization, and substrate specificity
Lipids
35
1117-1125
2000
Rattus norvegicus (Q564G3)
Manually annotated by BRENDA team
Ezanno, H.; Le Bloch, J.; Beauchamp, E.; Lagadic-Gossmann, D.; Legrand, P.; Rioux, V.
Myristic acid increases dihydroceramide DELTA4-desaturase 1 (DES1) activity in cultured rat hepatocytes
Lipids
47
117-128
2012
Rattus norvegicus (Q564G3)
Manually annotated by BRENDA team
Beckmann, C.; Rattke, J.; Sperling, P.; Heinz, E.; Boland, W.
Stereochemistry of a bifunctional dihydroceramide DELTA4-desaturase/hydroxylase from Candida albicans; a key enzyme of sphingolipid metabolism
Org. Biomol. Chem.
1
2448-2454
2003
Candida albicans
Manually annotated by BRENDA team
Luttgeharm, K.; Kimberlin, A.; Cahoon, R.; Cerny, R.; Napier, J.; Markham, J.; Cahoon, E.
Sphingolipid metabolism is strikingly different between pollen and leaf in Arabidopsis as revealed by compositional and gene expression profiling
Phytochemistry
115
121-129
2015
Arabidopsis thaliana
Manually annotated by BRENDA team
Zhu, Q.; Yang, J.; Zhu, R.; Jiang, X.; Li, W.; He, S.; Jin, J.
Dihydroceramide-desaturase-1-mediated caspase 9 activation through ceramide plays a pivotal role in palmitic acid-induced HepG2 cell apoptosis
Apoptosis
21
1033-1044
2016
Homo sapiens
Manually annotated by BRENDA team
Rodriguez-Cuenca, S.; Barbarroja, N.; Vidal-Puig, A.
Dihydroceramide desaturase 1, the gatekeeper of ceramide induced lipotoxicity
Biochim. Biophys. Acta
1851
40-50
2015
Chlorocebus aethiops, Mus musculus (O09005), Homo sapiens (O15121), Drosophila melanogaster (Q94515)
Manually annotated by BRENDA team
Casasampere, M.; Ordonez, Y.F.; Casas, J.; Fabrias, G.
Dihydroceramide desaturase inhibitors induce autophagy via dihydroceramide-dependent and independent mechanisms
Biochim. Biophys. Acta
1861
264-275
2017
Homo sapiens
Manually annotated by BRENDA team
Pou, A.; Abad, J.L.; Ordonez, Y.F.; Garrido, M.; Casas, J.; Fabrias, G.; Delgado, A.
From the configurational preference of dihydroceramide desaturase-1 towards DELTA6-unsaturated substrates to the discovery of a new inhibitor
Chem. Commun. (Camb.)
53
4394-4397
2017
Homo sapiens
Manually annotated by BRENDA team
Casasampere, M.; Ordonez, Y.F.; Pou, A.; Casas, J.
Inhibitors of dihydroceramide desaturase 1 Therapeutic agents and pharmacological tools to decipher the role of dihydroceramides in cell biology
Chem. Phys. Lipids
197
33-44
2016
Drosophila melanogaster, Drosophila melanogaster (Q94515), Mus musculus (O09005), Homo sapiens (O15121), Rattus norvegicus (Q5XIF5)
Manually annotated by BRENDA team
Cingolani, F.; Casasampere, M.; Sanllehi, P.; Casas, J.; Bujons, J.; Fabrias, G.
Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II
J. Lipid Res.
55
1711-1720
2014
Homo sapiens
Manually annotated by BRENDA team
Aurelio, L.; Scullino, C.V.; Pitman, M.R.; Sexton, A.; Oliver, V.; Davies, L.; Rebello, R.J.; Furic, L.; Creek, D.J.; Pitson, S.M.; Flynn, B.L.
From sphingosine kinase to dihydroceramide desaturase a structure-activity relationship (SAR) study of the enzyme inhibitory and anticancer activity of 4-((4-(4-chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II)
J. Med. Chem.
59
965-984
2016
Homo sapiens
Manually annotated by BRENDA team
Jang, Y.; Rao, X.; Jiang, Q.
Gamma-tocotrienol profoundly alters sphingolipids in cancer cells by inhibition of dihydroceramide desaturase and possibly activation of sphingolipid hydrolysis during prolonged treatment
J. Nutr. Biochem.
46
49-56
2017
Homo sapiens (O15121)
Manually annotated by BRENDA team
McNaughton, M.; Pitman, M.; Pitson, S.M.; Pyne, N.J.; Pyne, S.
Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells
Oncotarget
7
16663-16675
2016
Homo sapiens
Manually annotated by BRENDA team
Poliakov, E.; Samuel, W.; Duncan, T.; Gutierrez, D.B.; Mata, N.L.; Redmond, T.M.
Inhibitory effects of fenretinide metabolites N-[4-methoxyphenyl]retinamide (MPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (3-keto-HPR) on fenretinide molecular targets beta-carotene oxygenase 1, stearoyl-CoA desaturase 1 and dihydroceramide DELTA4-desaturase 1
PLoS ONE
12
e0176487
2017
Mus musculus (O09005), Homo sapiens (O15121), Mus musculus C57BL/6 (O09005)
Manually annotated by BRENDA team