1.14.14.32: 17alpha-hydroxyprogesterone deacetylase

This is an abbreviated version!
For detailed information about 17alpha-hydroxyprogesterone deacetylase, go to the full flat file.

Reaction

Synonyms

17,20 lyase, 17-20 lyase, 17-alpha-hydroxylase/C17-20 lyase, 17-hydroxylase/C17,20-lyase, 17alpha-hydroxylase, 17alpha-hydroxylase-C(17,20)-lyase, 17alpha-hydroxylase-C17,20-lyase, 17alpha-hydroxylase/17,20 lyase, 17alpha-hydroxylase/17,20-lyase, 17alpha-hydroxylase/17,20-lyase cytochrome P450, 17alpha-hydroxylase/C(17,20)-lyase, 17alpha-hydroxylase/C17,20-lyase, 17alpha-hydroxyprogesterone aldolase, 17alpha-hydroxyprogesterone aldolase/17,20-lyase, 17alpha-lyase, Adrenal 17,20-lyase, aldolase, 17alpha-hydroxyprogesterone, C-17,20 lyase, C-17/C-20 lyase, C17(20) lyase, C17,20 lyase, C17,20-lyase, CYP17, CYP17A1, cytochrome P450 17, cytochrome P450 17A1, cytochrome P450 17alpha-hydroxylase/17,20-lyase, cytochrome p450 17alpha-hydroxylase/C(17,20)-lyase, cytochrome P450c17, EC 4.1.2.30, P-45017alpha, P450 17A1, P45017alpha, P450c17, P450c17-I, steroid 17alphahydroxylase/17,20-lyase, Steroid C17(20) lyase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.32 17alpha-hydroxyprogesterone deacetylase

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Results	in table
19	Activating Compound
818	AA Sequence
10	Application
1	CAS Registry Number
20	Cloned(Commentary)
7	Cofactor
1	Crystallization (Commentary)
3627	Disease/ Diagnostics
5	Expression
11	General Information
84	IC50 Value
170	Inhibitors
11	kcat/KM [mM/s]
10	Ki Value [mM]
20	KM Value [mM]
38	Localization
3	Molecular Weight [Da]
59	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
207	Organism
7	Pathway
26	PDB ID
2	pH Optimum
2	Posttranslational Modification
32	Protein Variants
3	Reaction
9	Reaction Type
67	Reference
84	Source Tissue
15	Specific Activity [micromol/min/mg]
117	Substrates and Products (Substrate)
2	Subunits
109	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
13	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.14.14.32 - 17alpha-hydroxyprogesterone deacetylase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

17-hydroxy-5alpha-pregnan-3alpha-ol-20-one + [reduced NADPH-hemoprotein reductase] + O2

androsterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

P05093

-

734569

-

-

?

17-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2

androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Rattus norvegicus

-

-

695147, 706775

-

-

?

17alpha-hydroxy-5alpha-dihydroprogesterone + [reduced NADPH-hemoprotein reductase] + O2

5alpha-androstanedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

P05093

-

734569

-

-

?

17alpha-Hydroxypregnenolone

Dehydroepiandrosterone + acetaldehyde

9 entries

17alpha-hydroxypregnenolone + ? + cytochrome b5

dehydroepiandrosterone + ?

Homo sapiens

-

-

657657

-

-

?

17alpha-hydroxypregnenolone + AH2 + O2

?

Homo sapiens

-

-

714275

-

-

?

17alpha-hydroxypregnenolone + AH2 + O2

dehydroepiandrosterone + acetate + A + H2O

8 entries

17alpha-hydroxypregnenolone + [reduced NADPH-hemoprotein reductase] + O2

3beta-hydroxyandrost-5-en-17-one + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

P05093

-

737726

-

-

?

17alpha-hydroxypregnenolone + [reduced NADPH-hemoprotein reductase] + O2

dehydroepiandrosterone + [oxidized NADPH-hemoprotein reductase] + acetate + H2O

Homo sapiens

P05093

-

745365

-

-

?

17alpha-hydroxyprogesterone + ?

androstenedione + ?

Cavia porcellus

Q64410

-

658149

-

-

?

17alpha-hydroxyprogesterone + AH2 + O2

dehydroepiandrosterone + androstenedione + A + H2O

Homo sapiens

-

-

714275

-

-

?

17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2

androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

15 entries

17alpha-picolyl-androst-4-en-3beta,17beta-diol + [reduced NADPH-hemoprotein reductase] + O2

? + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Rattus norvegicus

-

-

732996

66% conversion in 17,20-lyase reaction

-

?

17beta-hydroxy-17alpha-picolyl-androst-4-en-3-one + [reduced NADPH-hemoprotein reductase] + O2

? + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Rattus norvegicus

-

-

732996

73% conversion in 17,20-lyase reaction

-

?

5alpha-dihydroprogesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxy-5alpha-dihydroprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

P05093

-

734569

-

-

?

5alpha-pregnan-17alpha-ol-3,20-dione + ?

androstanedione

Homo sapiens

-

-

657657

very little product formation

-

?

5alpha-pregnan-3alpha,17alpha-diol-20-one + ? + cytochrome b5

androsterone + ?

Homo sapiens

-

better substrate than 17alpha-hydroxypregenolone

657657

rapid reaction

-

?

5alpha-pregnan-3alpha-ol-20-one + [reduced NADPH-hemoprotein reductase] + O2

17-hydroxy-5alpha-pregnan-3alpha-ol-20-one + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

P05093

-

734569

-

-

?

7,12-dimethylbenz[a]anthracene + AH2 + O2

?

Homo sapiens

P05093

substrate for CYP17A1

714352

-

-

?

7-dehydro-17alpha-hydroxypregnenolone + AH2 + O2

7-dehydro-dehydroepiandrosterone + acetate + A + H2O

3 entries

7-dehydro-pregnenolone + AH2 + O2

7-dehydro-17alpha-hydroxy-pregnenolone + A + H2O

Homo sapiens

P05093

-

714352

-

-

?

7-dehydro-pregnenolone + AH2 + O2

7-dehydro-17alpha-hydroxypregnenolone + A + H2O

4 entries

7alpha-hydroxypregnenolone + [reduced NADPH-hemoprotein reductase] + O2

3beta-hydroxyandrost-5-en-17-one + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

17,20-lyase activity

693347

-

-

?

aflatoxin B1 + AH2 + O2

aflatoxin B1epoxide + A + H2O

Homo sapiens

P05093

substrate for CYP17A1

714352

-

-

?

allopregnanolone + [reduced NADPH-hemoprotein reductase] + O2

androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

P05093

-

737726

-

-

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Homo sapiens

P05093

-

714352

-

-

?

pregnenolone + reduced acceptor + O2

17alpha-hydroxypregnenolone + oxidized acceptor + H2O

Homo sapiens

-

i.e. pregn-5-en-3beta-ol-20-one

714275

-

-

?

pregnenolone + [reduced NADPH-hemoprotein reductase] + 2 O2

3beta-hydroxyandrost-5-en-17-one + acetate + [oxidized NADPH-hemoprotein reductase] + 2 H2O

Homo sapiens

P05093

-

745365

-

-

?

pregnenolone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O

3 entries

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

14 entries

progesterone + reduced acceptor + O2

17alpha-hydroxyprogesterone + acceptor + H2O

Homo sapiens

P05093

-

714352

-

-

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

16alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

P05093

minor product

745365

-

-

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

3 entries

additional information

?

-

26 entries

17alpha-Hydroxypregnenolone

Dehydroepiandrosterone + acetaldehyde

Homo sapiens

-

-

665842, 703945

-

-

?

17alpha-Hydroxypregnenolone

Dehydroepiandrosterone + acetaldehyde

Homo sapiens

-

-

5126

DHEA

5126

?

17alpha-Hydroxypregnenolone

Dehydroepiandrosterone + acetaldehyde

Homo sapiens

-

-

5131

DHEA

5131

?

17alpha-Hydroxypregnenolone

Dehydroepiandrosterone + acetaldehyde

Homo sapiens

-

17,20-lyase activity

693809, 695150

-

-

?

17alpha-Hydroxypregnenolone

Dehydroepiandrosterone + acetaldehyde

Macaca fascicularis

-

-

5130

DHEA

5130

?

17alpha-Hydroxypregnenolone

Dehydroepiandrosterone + acetaldehyde

Mesocricetus auratus

-

-

390127

DHEA

390127

?

17alpha-Hydroxypregnenolone

Dehydroepiandrosterone + acetaldehyde

Oncorhynchus mykiss

-

-

5127

DHEA

5127

?

17alpha-Hydroxypregnenolone

Dehydroepiandrosterone + acetaldehyde

Rattus norvegicus

-

-

5129

-

-

?

17alpha-Hydroxypregnenolone

Dehydroepiandrosterone + acetaldehyde

Rattus norvegicus

-

17,20-lyase activity

693885

-

-

?

17alpha-hydroxypregnenolone + AH2 + O2

dehydroepiandrosterone + acetate + A + H2O

Bison bison

-

-

714352

-

-

?

17alpha-hydroxypregnenolone + AH2 + O2

dehydroepiandrosterone + acetate + A + H2O

Cavia porcellus

-

-

714352

-

-

?

17alpha-hydroxypregnenolone + AH2 + O2

dehydroepiandrosterone + acetate + A + H2O

Felis catus

-

-

714352

-

-

?

17alpha-hydroxypregnenolone + AH2 + O2

dehydroepiandrosterone + acetate + A + H2O

Homo sapiens

P05093

-

714352

-

-

?

17alpha-hydroxypregnenolone + AH2 + O2

dehydroepiandrosterone + acetate + A + H2O

Mus musculus

-

-

714352

-

-

?

17alpha-hydroxypregnenolone + AH2 + O2

dehydroepiandrosterone + acetate + A + H2O

Pan troglodytes

-

-

714352

-

-

?

17alpha-hydroxypregnenolone + AH2 + O2

dehydroepiandrosterone + acetate + A + H2O

Papio sp.

-

-

714352

-

-

?

17alpha-hydroxypregnenolone + AH2 + O2

dehydroepiandrosterone + acetate + A + H2O

Rattus norvegicus

-

-

714352

-

-

?

17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2

androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Dicentrarchus labrax

-

-

677795

-

-

?

17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2

androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

665842, 680978

-

-

?

17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2

androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

P05093

-

737726, 745365

-

-

?

17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2

androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

745365

-

-

?

17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2

androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

5126

androstenedione

5126

?

17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2

androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

5131

androstenedione

5131

?

17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2

androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

17,20-lyase activity

695150

-

-

?

17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2

androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Macaca fascicularis

-

-

5130

-

5130

?

17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2

androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Mesocricetus auratus

-

-

390127

androstenedione

390127

?

17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2

androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Mus musculus

-

-

5128

androstenedione, immediate precursor of testosterone

5128

?

17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2

androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Oncorhynchus mykiss

-

-

5127

-

5127

?

17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2

androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Oryctolagus cuniculus

-

-

5125

-

5125

?

17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2

androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Rattus norvegicus

-

-

5129

-

5129

?

17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2

androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Rattus norvegicus

-

-

702581, 706775, 713129, 713518, 732996

-

-

?

17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2

androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O

Rattus norvegicus

-

17,20-lyase activity

693885

-

-

?

7-dehydro-17alpha-hydroxypregnenolone + AH2 + O2

7-dehydro-dehydroepiandrosterone + acetate + A + H2O

Homo sapiens

P05093

-

728827

-

-

?

7-dehydro-17alpha-hydroxypregnenolone + AH2 + O2

7-dehydro-dehydroepiandrosterone + acetate + A + H2O

Homo sapiens

P05093

low activity

714352

-

-

?

7-dehydro-17alpha-hydroxypregnenolone + AH2 + O2

7-dehydro-dehydroepiandrosterone + acetate + A + H2O

Sus scrofa

-

-

728827

-

-

?

7-dehydro-pregnenolone + AH2 + O2

7-dehydro-17alpha-hydroxypregnenolone + A + H2O

Bos taurus

-

-

714352

-

-

?

7-dehydro-pregnenolone + AH2 + O2

7-dehydro-17alpha-hydroxypregnenolone + A + H2O

Capra hircus

-

-

714352

-

-

?

7-dehydro-pregnenolone + AH2 + O2

7-dehydro-17alpha-hydroxypregnenolone + A + H2O

Homo sapiens

P05093

-

714352

-

-

?

7-dehydro-pregnenolone + AH2 + O2

7-dehydro-17alpha-hydroxypregnenolone + A + H2O

Ovis aries

-

-

714352

-

-

?

pregnenolone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

735283

-

-

?

pregnenolone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

P05093

-

734569, 745365

-

-

?

pregnenolone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

745365

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

Bison bison

-

-

714352

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

Bos taurus

-

-

714352

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

Capra hircus

-

-

714352

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

Cavia porcellus

-

-

714352

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

Equus caballus

-

-

714352

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

Felis catus

-

-

714352

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

Homo sapiens

-

-

714275

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

Homo sapiens

P05093

-

714352

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

Mus musculus

-

-

714352

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

Ovis aries

-

-

714352

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

Pan troglodytes

-

-

714352

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

Papio sp.

-

-

714352

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

Rattus norvegicus

-

-

714352

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

Sus scrofa

-

-

714352

-

-

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

735283

-

-

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

P05093

-

734569, 745365

-

-

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

745365

-

-

?

additional information

?

-

Bison bison

-

the bison enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview

714352

-

-

?

additional information

?

-

Bos taurus

-

the bovine enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview

714352

-

-

?

additional information

?

-

Capra hircus

-

the goat enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview

714352

-

-

?

additional information

?

-

Cavia porcellus

Q64410

enzyme catalyzes both 17alpha-hydroxylation of steroids, EC 1.14.99.9, and 17,20-lyase reaction, lyase activity is realized only with 17alpha-hydroxyprogesterone

658149

-

-

?

additional information

?

-

Cavia porcellus

-

the guinea pig enzyme belongs to the DELTA4-type CYP17, which has no, or very low, 17,20-lyase activity with 17alpha-hydroxy-pregnenolone with the formation of dehydroepiandrosterone, substrate specificity, comparison of different species, overview

714352

-

-

?

additional information

?

-

Equus caballus

-

the horse enzyme belongs to the DELTA4,5-type of CYP17, which catalyses the 17alpha-hydroxylation of progesterone and pregnenolone and the 17,20-lyase reaction of 17alpha-hydroxy-progesterone and 17alpha-hydroxy-pregnenolone, substrate specificity, comparison of different species, overview

714352

-

-

?

additional information

?

-

Felis catus

-

the cat enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview

714352

-

-

?

additional information

?

-

Homo sapiens

-

acute elevation of serum insulin levels into the high physiological range selectively inhibits enzyme activity in man. This enzymatic step is involved in biosynthesis of the adrenal androgens androstenedione and dehydroepiandrosterone (DHEA)

5126

-

-

?

additional information

?

-

Homo sapiens

-

enzyme also catalyzes hydroxylation of pregnenolone to 17alpha-hydroxypregnenolone and of progesterone to 17alpha-hydroxyprogesterone

665842

-

-

?

additional information

?

-

Homo sapiens

P05093

the human enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview

714352

-

-

?

additional information

?

-

Homo sapiens

P05093

CYP17 has both 17alpha-hydroxylase and 17,20-lyase activities

714352

-

-

?

additional information

?

-

Homo sapiens

P05093

no activity with 17alpha-hydroxyprogesterone

714352

-

-

?

additional information

?

-

Homo sapiens

P05093

the enzyme shows also about 20% 16alpha-hydroxylase activity and some 21alpha-hydroxylase activity with progesterone

734569

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme shows also about 20% 16alpha-hydroxylase activity and some 21alpha-hydroxylase activity with progesterone

734569

-

-

?

additional information

?

-

Homo sapiens

P05093

P450 17A1 is an inherently distributive enzyme but some processivity is present, i.e. some of the 17alpha-hydroxypregnenolone formed from pregnenolone does not dissociate from P450 17A1 before conversion to dehydroepiandrosterone

745365

-

-

?

additional information

?

-

Homo sapiens

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P450 17A1 is an inherently distributive enzyme but some processivity is present, i.e. some of the 17alpha-hydroxypregnenolone formed from pregnenolone does not dissociate from P450 17A1 before conversion to dehydroepiandrosterone

745365

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additional information

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Mesocricetus auratus

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adrenal cytochrome P450C17 enzyme is capable of transforming pregnenolone into DHEA

390127

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additional information

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Mus musculus

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substrate specificity, comparison of different species, overview

714352

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additional information

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Oncorhynchus mykiss

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cytochrome P-450c17 mediates both 17alpha-hydroxylase and 17,20 lyase activities in the synthesis of steroid hormones

5127

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additional information

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Oryctolagus cuniculus

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enzyme of the biosynthetic pathway for testosterone synthesis. Impairment of the reaction occurs in autoimmunized rabbits with severe damage of testes

5125

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additional information

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Ovis aries

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the sheep enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview

714352

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?

additional information

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Pan troglodytes

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the chimp enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview

714352

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?

additional information

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Papio sp.

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the baboon enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview

714352

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?

additional information

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Rattus norvegicus

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the rat enzyme belongs to the DELTA4,5-type of CYP17, which catalyses the 17alpha-hydroxylation of progesterone and pregnenolone and the 17,20-lyase reaction of 17alpha-hydroxy-progesterone and 17alpha-hydroxy-pregnenolone, substrate specificity, comparison of different species, overview

714352

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?

additional information

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Rattus norvegicus

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the enzyme catalyses two independent reactions at the same active site, the 17-hydroxylation of pregnenolone and progesterone (reaction of EC 1.14.14.19), and the conversion of the 17-hydroxylated products via a 17,20-lyase reaction. The C17,20-lyase reaction is rate limiting, and 5–25% of the 17OH-progesterone product is converted to 4-en-dione

732996

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additional information

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Sus scrofa

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the pig enzyme belongs to the DELTA4,5-type of CYP17, which catalyses the 17alpha-hydroxylation of progesterone and pregnenolone and the 17,20-lyase reaction of 17alpha-hydroxy-progesterone and 17alpha-hydroxy-pregnenolone, substrate specificity, comparison of different species, overview

714352

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?