Cloned (Comment) | Organism |
---|---|
full length cDNA clone encoding cytochrome P-450c17 (17alpha-hydrolase/17,20 lyase), expression in mammalian COS-1 cells | Oncorhynchus mykiss |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Oncorhynchus mykiss | cytochrome P-450c17 mediates both 17alpha-hydroxylase and 17,20 lyase activities in the synthesis of steroid hormones | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oncorhynchus mykiss | - |
rainbow trout | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ovarian follicle | ovarian | Oncorhynchus mykiss | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17alpha-Hydroxypregnenolone | - |
Oncorhynchus mykiss | Dehydroepiandrosterone + acetaldehyde | DHEA | ? | |
17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Oncorhynchus mykiss | androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
additional information | cytochrome P-450c17 mediates both 17alpha-hydroxylase and 17,20 lyase activities in the synthesis of steroid hormones | Oncorhynchus mykiss | ? | - |
? |