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1.14.14.32: 17alpha-hydroxyprogesterone deacetylase

This is an abbreviated version!
For detailed information about 17alpha-hydroxyprogesterone deacetylase, go to the full flat file.

Word Map on EC 1.14.14.32

Reaction

17alpha-hydroxypregnenolone
+
[reduced NADPH-hemoprotein reductase]
 +
O2
=
3beta-hydroxyandrost-5-en-17-one
 +
acetate
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

17,20 lyase, 17-20 lyase, 17-alpha-hydroxylase/C17-20 lyase, 17-hydroxylase/C17,20-lyase, 17alpha-hydroxylase, 17alpha-hydroxylase-C(17,20)-lyase, 17alpha-hydroxylase-C17,20-lyase, 17alpha-hydroxylase/17,20 lyase, 17alpha-hydroxylase/17,20-lyase, 17alpha-hydroxylase/17,20-lyase cytochrome P450, 17alpha-hydroxylase/C(17,20)-lyase, 17alpha-hydroxylase/C17,20-lyase, 17alpha-hydroxyprogesterone aldolase, 17alpha-hydroxyprogesterone aldolase/17,20-lyase, 17alpha-lyase, Adrenal 17,20-lyase, aldolase, 17alpha-hydroxyprogesterone, C-17,20 lyase, C-17/C-20 lyase, C17(20) lyase, C17,20 lyase, C17,20-lyase, CYP17, CYP17A1, cytochrome P450 17, cytochrome P450 17A1, cytochrome P450 17alpha-hydroxylase/17,20-lyase, cytochrome p450 17alpha-hydroxylase/C(17,20)-lyase, cytochrome P450c17, EC 4.1.2.30, P-45017alpha, P450 17A1, P45017alpha, P450c17, P450c17-I, steroid 17alphahydroxylase/17,20-lyase, Steroid C17(20) lyase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.32 17alpha-hydroxyprogesterone deacetylase

Expression

Expression on EC 1.14.14.32 - 17alpha-hydroxyprogesterone deacetylase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
CYP17 mRNA levels are reduced by 50% in CYP17 chimeric compared to wild-type mouse brain, whereas the levels of brain dehydroepiandrosterone levels are comparable
CYP17A1 gene expression continuously rises throughout the ovarian development, except for a slight drop during the primary yolk stage. During the atretic follicles stage, the expression of CYP17A1 is remarkably upregulated and reaches the highest level. During the tertiary yolk stage, brain CYP17AI expression is 3.1fold higher than the primary yolk stage, and 4.4fold higher than that at atretic follicles stage
in the brain, during the atretic follicles stage, the gene expression drops sharply to the lowest level
shRNA treatment significantly decreases CYP17 mRNA and protein levels in vitro. Silence efficiency of three constructed lentivirus shRNAs is 65.5%, 73.7% and 77.4%, respectively. Three constructed lentivirus shRNAs also have silencing effects on CYP17 protein expression, and their silence efficiencies are 50%, 50% and 61%, respectively. In vivo, shRNA still has a specific silencing effect on CYP17
-