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Literature summary for 1.14.14.32 extracted from
- Homology modelling of the enzyme P450 17alpha-hydroxylase/17,20-lyase-a taget for prostate cancer chemotherapy-from the crystal structure of P450BM-3 (1997), Anticancer Drug Des., 12, 113-123.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | homology modelling of the enzyme cytochrome P450 17alpha-hydroxylase/17,20-lyase (P450c17)-a target for prostate cancer chemotherapy-from the crystal structure of P450BM-3 | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ketoconazole | - |
Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 17alpha-Hydroxypregnenolone | - |
Homo sapiens | Dehydroepiandrosterone + acetaldehyde | DHEA | ? | |
| 17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O | androstenedione | ? | |
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Release 2023.1 (January 2023)
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