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Literature summary for 1.14.14.32 extracted from

  • Nestler, J.E.; McClanahan, M.A.; Clore, J.N.; Blackard, W.G.
    Insulin inhibits adrenal 17,20-lyase activity in man (1992), J. Clin. Endocrinol., 74, 362-367.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
Insulin acute and selective Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens acute elevation of serum insulin levels into the high physiological range selectively inhibits enzyme activity in man. This enzymatic step is involved in biosynthesis of the adrenal androgens androstenedione and dehydroepiandrosterone (DHEA) ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17alpha-Hydroxypregnenolone
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 Homo sapiens Dehydroepiandrosterone + acetaldehyde DHEA ?
17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2
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 Homo sapiens androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O androstenedione ?
additional information acute elevation of serum insulin levels into the high physiological range selectively inhibits enzyme activity in man. This enzymatic step is involved in biosynthesis of the adrenal androgens androstenedione and dehydroepiandrosterone (DHEA) Homo sapiens ?
-
 ?