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0.18 - 0.72
10-[(N,N-dimethylaminooctyl)-2-(trifluoromethyl)]phenothiazine
1.7
bicyclo[4.2.0]octan-7-one
-
at pH 8.0 and 20°C
1.3
Cyclobutanone
-
at pH 8.0 and 20°C
1.83
cysteamine
-
at pH 8.0 and 25°C
0.036 - 0.05
ethylenethiourea
1.25 - 71.1
methyl p-tolyl sulfide
1.8
N,N-Dimethylaniline
-
pH 8.5, 25°C
0.1 - 0.33
N-methyl-tamoxifen
2
NADH
-
with bicyclo[3.2.0]hept-2-en-6-one as cosubstrate, at pH 8.0 and 20°C
3
Nicotine
-
pH 8.5, 25°C
0.023
selegiline
-
pH and temperature not specified in the publication
0.0042 - 0.027
sulindac sulfide
0.023 - 1.335
thiacetazone
0.67
Thiourea
-
at pH 8.0 and 25°C
0.155
tozasertib
-
pH and temperature not specified in the publication
0.034 - 6.1
trimethylamine
0.18
10-[(N,N-dimethylaminooctyl)-2-(trifluoromethyl)]phenothiazine
-
pH 8.5, 37°C, detergent is a minimal detergent, recombinant MBP-FMO3
0.19
10-[(N,N-dimethylaminooctyl)-2-(trifluoromethyl)]phenothiazine
-
pH 8.5, 37°C, detergent is CHAPS, recombinant MBP-FMO3
0.22
10-[(N,N-dimethylaminooctyl)-2-(trifluoromethyl)]phenothiazine
-
pH 8.5, 37°C, detergent is Triton X-100, recombinant MBP-FMO3
0.55
10-[(N,N-dimethylaminooctyl)-2-(trifluoromethyl)]phenothiazine
-
pH 8.5, 37°C, detergent is a minimal detergent, commercial recombinant FMO3
0.67
10-[(N,N-dimethylaminooctyl)-2-(trifluoromethyl)]phenothiazine
-
pH 8.5, 37°C, detergent is CHAPS, commercial recombinant FMO3
0.72
10-[(N,N-dimethylaminooctyl)-2-(trifluoromethyl)]phenothiazine
-
pH 8.5, 37°C, detergent is Triton X-100, commercial recombinant FMO3
0.003
Benzydamine
recombinant His-tagged full-length mutant E308G, pH 7.4, 37°C
0.008
Benzydamine
recombinant His-tagged truncated mutant E308G, pH 7.4, 37°C
0.018
Benzydamine
recombinant His-tagged full-length mutant E158K, pH 7.4, 37°C
0.029
Benzydamine
recombinant His-tagged truncated mutant E158K, pH 7.4, 37°C
0.051
Benzydamine
recombinant His-tagged full-length mutant V257M, pH 7.4, 37°C
0.052
Benzydamine
recombinant His-tagged full-length wild-type enzyme, pH 7.4, 37°C
0.058
Benzydamine
recombinant His-tagged truncated mutant V257M, pH 7.4, 37°C
0.075
Benzydamine
recombinant His-tagged truncated wild-type enzyme, pH 7.4, 37°C
0.15
Benzydamine
-
pH and temperature not specified in the publication
0.0012
clomiphene
recombinant wild-type enzyme, pH 7.4, 37°C
0.0017
clomiphene
-
pH and temperature not specified in the publication
0.0042
clomiphene
recombinant mutant E308G, pH 7.4, 37°C
0.005
clomiphene
recombinant mutant V257M, pH 7.4, 37°C
0.01
clomiphene
recombinant mutant E158K, pH 7.4, 37°C
0.805
Ethionamide
37°C, isozyme FMO2
0.805
Ethionamide
isozyme FMO2, at pH 9.5 and 37°C
0.973
Ethionamide
37°C, isozyme FMO3
1.01
Ethionamide
37°C, isozyme FMO3
1.5
Ethionamide
37°C, isozyme FMO1
1.5
Ethionamide
isozyme FMO1, at pH 9.5 and 37°C
4.52
Ethionamide
37°C, isozyme FMO1
4.52
Ethionamide
isozyme FMO1, at pH 9.5 and 37°C
9.45
Ethionamide
37°C, isozyme FMO2
9.45
Ethionamide
isozyme FMO2, at pH 9.5 and 37°C
0.036
ethylenethiourea
-
recombinant wild-type enzyme, pH 8.5
0.042
ethylenethiourea
-
recombinant mutant K416N, pH 8.5
0.05
ethylenethiourea
-
recombinant mutant E24D, pH 8.5
0.0193
GSK5182
recombinant mutant E158K, pH 7.4, 37°C
0.02
GSK5182
recombinant mutant E308G, pH 7.4, 37°C
0.037
GSK5182
recombinant wild-type enzyme, pH 7.4, 37°C
0.095
GSK5182
recombinant mutant V257M, pH 7.4, 37°C
0.31
indole
-
pH 8.0, 25°C, recombinant Y207W
0.42
indole
-
pH 8.0, 25°C, recombinant W319A
0.64
indole
-
pH 8.0, 25°C, recombinant W319F
0.7
indole
-
pH 8.5, 25°C
0.7
indole
-
pH 8.0, 25°C, recombinant C78L
0.79
indole
-
pH 8.0, 25°C, recombinant C78A
0.8
indole
-
pH 8.0, 25°C, recombinant Y207W/W319A
0.85
indole
-
pH 8.0, 25°C, recombinant wild-type enzyme
0.93
indole
-
pH 8.0, 25°C, recombinant C78I/Y207W/W319A
1.04
indole
-
pH 8.0, 25°C, recombinant C78V
1.28
indole
-
pH 8.0, 25°C, recombinant C78I
0.004
Methimazole
-
recombinant mutant N61K, pH 8.5
0.038
Methimazole
9.5, 37°C, FMO1
0.043
Methimazole
9.5, 37°C, FMO3
0.047
Methimazole
-
recombinant mutant K416N, pH 8.5
0.124
Methimazole
-
recombinant wild-type enzyme, pH 8.5
0.22
Methimazole
-
recombinant mutant E24D, pH 8.5
0.525
Methimazole
9.5, 37°C, FMO2.1
0.67
Methimazole
-
mutant W47F, pH 8.5, 25°C
1
Methimazole
-
pH 8.5, 25°C
2.7
Methimazole
-
wild-type, pH 8.5, 25°C
1.25
methyl p-tolyl sulfide
-
pH 8.5, FMO2
2.9
methyl p-tolyl sulfide
-
pH 8.5, FMO1
10
methyl p-tolyl sulfide
pH 9.0, 37°C, mutant S195L
42.3
methyl p-tolyl sulfide
pH 9.0, 37°C, wild-type FMO2.1
71.1
methyl p-tolyl sulfide
pH 9.0, 37°C, mutant N413K
0.1
N-methyl-tamoxifen
-
about, recombinant isozyme FMO3
0.33
N-methyl-tamoxifen
-
about, recombinant isozyme FMO1
0.06
NADPH
-
pH 8.5, 25°C
0.92
NADPH
-
mutant W47F, pH 8.5, 25°C
2.8
NADPH
-
with bicyclo[3.2.0]hept-2-en-6-one as cosubstrate, at pH 8.0 and 20°C
7.3
NADPH
-
wild-type, pH 8.5, 25°C
15.2
NADPH
pH 9.0, 37°C, mutant S195L
23.6
NADPH
pH 9.0, 37°C, wild-type FMO2.1
94.4
NADPH
pH 9.0, 37°C, mutant N413K
2.7
O2
-
mutant W47F, pH 8.5, 25°C
7.7
O2
-
wild-type, pH 8.5, 25°C
0.003
sulindac
-
recombinant mutant N61K, pH 8.5
0.044
sulindac
-
recombinant mutant E24D, pH 8.5
0.047
sulindac
-
recombinant wild-type enzyme, pH 8.5
0.068
sulindac
-
recombinant mutant K416N, pH 8.5
0.0042
sulindac sulfide
recombinant His-tagged full-length mutant E158K, pH 7.4, 37°C
0.0062
sulindac sulfide
recombinant His-tagged full-length mutant E308G, pH 7.4, 37°C
0.0068
sulindac sulfide
recombinant His-tagged full-length mutant V257M, pH 7.4, 37°C
0.0093
sulindac sulfide
recombinant His-tagged full-length wild-type enzyme, pH 7.4, 37°C
0.0115
sulindac sulfide
recombinant His-tagged truncated mutant E158K, pH 7.4, 37°C
0.0148
sulindac sulfide
recombinant His-tagged truncated mutant E308G, pH 7.4, 37°C
0.0183
sulindac sulfide
recombinant His-tagged truncated mutant V257M, pH 7.4, 37°C
0.027
sulindac sulfide
recombinant His-tagged truncated wild-type enzyme, pH 7.4, 37°C
0.0062
tamoxifen
recombinant His-tagged full-length mutant E308G, pH 7.4, 37°C
0.0063
tamoxifen
recombinant mutant E308G, pH 7.4, 37°C
0.0075
tamoxifen
recombinant His-tagged full-length mutant E158K, pH 7.4, 37°C
0.0075
tamoxifen
recombinant mutant E158K, pH 7.4, 37°C
0.0098
tamoxifen
recombinant His-tagged full-length mutant V257M, pH 7.4, 37°C
0.01
tamoxifen
recombinant His-tagged truncated mutant E308G, pH 7.4, 37°C
0.01
tamoxifen
recombinant mutant V257M, pH 7.4, 37°C
0.0113
tamoxifen
recombinant His-tagged truncated mutant E158K, pH 7.4, 37°C
0.0142
tamoxifen
recombinant His-tagged truncated mutant V257M, pH 7.4, 37°C
0.0188
tamoxifen
recombinant wild-type enzyme, pH 7.4, 37°C
0.0188
tamoxifen
recombinant His-tagged full-length wild-type enzyme, pH 7.4, 37°C
0.0272
tamoxifen
recombinant His-tagged truncated wild-type enzyme, pH 7.4, 37°C
0.273
tamoxifen
-
pH and temperature not specified in the publication
1.02
tamoxifen
-
pH 8.5, 37°C, recombinant wild-type isozyme FMO3
1.7
tamoxifen
-
pH 8.5, 37°C, recombinant mutant isozyme FMO3 E158K
3.18
tamoxifen
-
pH 8.5, 37°C, recombinant isozyme FMO1
0.023
thiacetazone
9.5, 37°C, FMO3
0.048
thiacetazone
-
recombinant EtaA, pH 9.0, 37°C, thiacetazone carbodiimide formation
0.085
thiacetazone
-
recombinant EtaA, pH 9.0, 37°C, thiacetazone sulfinic acid formation
0.085
thiacetazone
9.5, 37°C, FMO1
1.335
thiacetazone
9.5, 37°C, FMO2.1
0.034
trimethylamine
-
recombinant wild-type enzyme, pH 8.5
0.051
trimethylamine
-
recombinant mutant K416N, pH 8.5
0.065
trimethylamine
-
recombinant mutant E24D, pH 8.5
1.25
trimethylamine
-
mutant W47F, pH 8.5, 25°C
2.6
trimethylamine
-
at pH 8.0 and 25°C
6.1
trimethylamine
-
pH 8.5, 25°C
6.1
trimethylamine
-
wild-type, pH 8.5, 25°C