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Literature summary for 1.14.13.8 extracted from
- Characterization of mouse flavin-containing monooxygenase transcript levels in lung and liver, and activity of expressed isoforms (2008), Biochem. Pharmacol., 75, 570-579.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| genes fmo1, fmo2, fmo3, quantitative expression analysis in different tissues, expression in Spodoptera frugiperda Sf9 cells using the baculovirus transfection system | Mus musculus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 3.6 | - |
methyl p-tolyl sulfide | pH 8.5, FMO1 | Mus musculus |  |
| 10.2 | - |
methyl p-tolyl sulfide | pH 8.5, FMO2 | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Mus musculus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
several strains, overview, genes fmo1, fmo2, fmo3, and fmo5 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
| lung | - |
Mus musculus | - |
| additional information | tissue-specific expression of FMO isozymes, quantitative expression analysis, overview | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| methimazole + NADPH + H+ + O2 | FMO1, FMO2, and FMO3 | Mus musculus | ? | - |
? | |
| methyl p-tolyl sulfide + NADPH + H+ + O2 | FMO1, FMO2, but poor substrate of FMO3 | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FMO | - |
Mus musculus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
10 min, elimination of most Fmo1 and Fmo3 activity, while 94% of Fmo2 activity remains | Mus musculus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.25 | - |
methyl p-tolyl sulfide | pH 8.5, FMO2 | Mus musculus | |
| 2.9 | - |
methyl p-tolyl sulfide | pH 8.5, FMO1 | Mus musculus | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | 9.5 | assay at | Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Mus musculus | |
| NADPH | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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