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Disease on EC 1.14.13.8 - flavin-containing monooxygenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Agranulocytosis
Novel Association between Flavin-Containing Monooxygenase 3 Gene Polymorphism and Antithyroid Drug-Induced Agranulocytosis in the Han Population.
Amyotrophic Lateral Sclerosis
Flavin-Containing Monooxygenase mRNA Levels are Up-Regulated in ALS Brain Areas in SOD1-Mutant Mice.
Anemia, Sideroblastic
Abnormalities of flavin monooxygenase as an etiology for sideroblastic anemia.
Arteriosclerosis
Different Effects of Polymorphic Flavin-Containing Monooxygenase 3 and Cytochrome P450 2A6 Activities on an Index of Arteriosclerosis as a Lifestyle-Related Disease in a General Population in Japan.
Ascorbic Acid Deficiency
Ascorbic acid deficiency and the flavin-containing monooxygenase.
Flavin-containing monooxygenase and ascorbic acid deficiency. Qualitative and quantitative differences.
Asthma
Guiding Medicinal Chemistry with Fragment Molecular Orbital (FMO) Method.
Atherosclerosis
Acrolein-induced atherogenesis by stimulation of hepatic flavin containing monooxygenase 3 and a protection from hydroxytyrosol.
Binding of methimazole and NADP(H) to human FMO3: In vitro and in silico studies.
Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis.
Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis.
Flavin-Containing Monooxygenase 3 Reduces Endoplasmic Reticulum Stress in Lipid-Treated Hepatocytes.
The contributory role of gut microbiota in cardiovascular disease.
Carcinoma, Hepatocellular
Flavin-containing monooxygenase-3: induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver.
Cardiovascular Diseases
Drug Discovery and Development of Novel Therapeutics for Inhibiting TMAO in Models of Atherosclerosis and Diabetes.
Genetic Deficiency of Flavin-Containing Monooxygenase 3 ( Fmo3) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels-Brief Report.
The contributory role of gut microbiota in cardiovascular disease.
Colorectal Neoplasms
Effects of genetic polymorphisms of MDR1, FMO3 and CYP1A2 on susceptibility to colorectal cancer in Koreans.
Overexpression of flavin-containing monooxygenase 5 predicts poor prognosis in patients with colorectal cancer.
The roles of microbial products in the development of colorectal cancer: a review.
Dehydration
Early Oxidative Transformations During the Biosynthesis of Terrein and Related Natural Products.
Drug-Related Side Effects and Adverse Reactions
Some distinctions between flavin-containing and cytochrome P450 monooxygenases.
Endotoxemia
Suppression of flavin-containing monooxygenase by overproduced nitric oxide in rat liver.
Essential Hypertension
Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians.
The Flavin-Containing Monooxygenase 3 Gene and Essential Hypertension: The Joint Effect of Polymorphism E158K and Cigarette Smoking on Disease Susceptibility.
Fatty Liver
Dietary trans 10, cis 12-conjugated linoleic acid reduces the expression of fatty acid oxidation and drug detoxification enzymes in mouse liver.
flavin-containing monooxygenase deficiency
Flavin-containing monooxygenase 1 deficiency promotes neuroinflammation in dopaminergic neurons in mice.
Genetic Diseases, Inborn
Genetic variants of flavin-containing monooxygenase 3 (FMO3) derived from Japanese subjects with the trimethylaminuria phenotype and whole-genome sequence data from a large Japanese database.
Novel variants in outer protein surface of flavin-containing monooxygenase 3 found in an Argentinian case with impaired capacity for trimethylamine N-oxygenation.
Heart Diseases
Association of Flavin Monooxygenase Gene E158K Polymorphism with Chronic Heart Disease Risk.
Hematologic Neoplasms
Variability of voriconazole concentrations in patients with hematopoietic stem cell transplantation and hematological malignancies: influence of loading dose, procalcitonin, and pregnane X receptor polymorphisms.
Hemochromatosis
Abnormalities of flavin monooxygenase as an etiology for sideroblastic anemia.
Hypertension
Biochemical and clinical aspects of the human flavin-containing monooxygenase form 3 (FMO3) related to trimethylaminuria.
Hyperthyroidism
Olfactory toxicity of methimazole: dose-response and structure-activity studies and characterization of flavin-containing monooxygenase activity in the Long-Evans rat olfactory mucosa.
Infections
Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans.
NHR-49/PPAR-? and HLH-30/TFEB cooperate for C. elegans host defense via a flavin-containing monooxygenase.
Selective role for tumor necrosis factor-?, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen.
Inflammatory Bowel Diseases
The roles of microbial products in the development of colorectal cancer: a review.
Influenza, Human
Ab initio fragment molecular orbital studies of influenza virus hemagglutinin-sialosaccharide complexes toward chemical clarification about the virus host range determination.
Binding interaction analysis of the active site and its inhibitors for neuraminidase (N1 subtype) of human influenza virus by the integration of molecular docking, FMO calculation and 3D-QSAR CoMFA modeling.
Insulin Resistance
Supplementation of endogenous Ahr ligands reverses insulin resistance and associated inflammation in an insulin-dependent diabetic mouse model.
Ischemic Stroke
Flavin containing monooxygenase 3 genetic polymorphisms Glu158Lys and Glu308Gly and their relation to ischemic stroke.
Kidney Diseases
Metabolism and disposition kinetics of nicotine.
Leukemia, Myeloid, Acute
Increased frequency of TIGIT+CD73-CD8+ T cells with a TOX+ TCF-1low profile in patients with newly diagnosed and relapsed AML.
Liver Neoplasms
Accurate 3D-dose-based generation of MLC segments for robotic radiotherapy.
Mastitis
Evaluation of frequent milkout for treatment of cows with experimentally induced Escherichia coil mastitis.
Neoplasms
Flavin-Containing Monooxygenase 3 Polymorphic Variants Significantly Affect Clearance of Tamoxifen and Clomiphene.
Flavin-dependent enzymes in cancer prevention.
Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells.
Multi-Omics Sequencing Provides Insights Into Age-Dependent Susceptibility of Grass Carp (Ctenopharyngodon idellus) to Reovirus.
Robust beam orientation optimization for intensity-modulated proton therapy.
The aromatase inactivator 4-hydroxyandrostenedione (4-OH-A) inhibits tamoxifen metabolism by rat hepatic cytochrome P-450 3A: potential for drug-drug interaction of tamoxifen and 4-OH-A in combined anti-breast cancer therapy.
The roles of microbial products in the development of colorectal cancer: a review.
Tumor Microenvironment Responsive Biodegradable Fe-Doped MoOx Nanowires for Magnetic Resonance Imaging Guided Photothermal-Enhanced Chemodynamic Synergistic Antitumor Therapy.
Neuroinflammatory Diseases
Flavin-containing monooxygenase 1 deficiency promotes neuroinflammation in dopaminergic neurons in mice.
Obesity
The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue.
Obstetric Labor, Premature
Effects of single-nucleotide polymorphisms of FMO3 and FMO6 genes on pharmacokinetic characteristics of sulindac sulfide in premature labor.
Parkinson Disease
Flavin-containing monooxygenase 1 deficiency promotes neuroinflammation in dopaminergic neurons in mice.
Parkinsonian Disorders
Flavin-containing monooxygenase, a new clue of pathological proteins in the rotenone model of parkinsonism.
Prostatic Neoplasms
Accurate 3D-dose-based generation of MLC segments for robotic radiotherapy.
Pseudomonas Infections
The glycosyltransferase UGT76B1 modulates N-hydroxy-pipecolic acid homeostasis and plant immunity.
Sepsis
Suppression of flavin-containing monooxygenase by overproduced nitric oxide in rat liver.
Starvation
Aspergillus flavus squalene synthase as an antifungal target: Expression, activity, and inhibition.
Thrombosis
Association of FMO3 rs1736557 polymorphism with clopidogrel response in Chinese patients with coronary artery disease.
Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk.
Genetic Deficiency of Flavin-Containing Monooxygenase 3 ( Fmo3) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels-Brief Report.
Tuberculosis
A flavin-dependent monooxygenase from mycobacterium tuberculosis involved in cholesterol catabolism.
Bioactivation of antituberculosis thioamide and thiourea prodrugs by bacterial and mammalian flavin monooxygenases.
Biotransformation and bioactivation reactions - 2015 literature highlights.
EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator.
Human flavin-containing monooxygenase 2.1 catalyzes oxygenation of the antitubercular drugs thiacetazone and ethionamide.
Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes.
Oxidative Activation of Thiacetazone by the Mycobacterium tuberculosis Flavin Monooxygenase EtaA and Human FMO1 and FMO3.
The prodrug activator EtaA from Mycobacterium tuberculosis is a Baeyer-Villiger monooxygenase.
Xanthates: Metabolism by Flavoprotein-Containing Monooxygenases and Antimycobacterial Activity.
Virus Diseases
Multi-Omics Sequencing Provides Insights Into Age-Dependent Susceptibility of Grass Carp (Ctenopharyngodon idellus) to Reovirus.
Suppression of flavin-containing monooxygenase by overproduced nitric oxide in rat liver.