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Literature summary for 1.14.13.8 extracted from

  • Francois, A.A.; Nishida, C.R.; de Montellano, P.R.; Phillips, I.R.; Shephard, E.A.
    Human flavin-containing monooxygenase 2.1 catalyzes oxygenation of the antitubercular drugs thiacetazone and ethionamide (2009), Drug Metab. Dispos., 37, 178-186.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of FMO1, FMO2.1, and FMO3 in Spodoptera frugiperda Sf9 cell microsomes Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0058
-
thiacetazone 9.5, 37°C, FMO2.1 Homo sapiens
0.0063
-
thiacetazone 9.5, 37°C, FMO1 Homo sapiens
0.007
-
thiacetazone 9.5, 37°C, FMO3 Homo sapiens
0.0081
-
Methimazole 9.5, 37°C, FMO1 Homo sapiens
0.0293
-
Methimazole 9.5, 37°C, FMO3 Homo sapiens
0.5758
-
Methimazole 9.5, 37°C, FMO2.1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q01740
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
etionamide + NADPH + H+ + O2 substrate of FMO1, FMO3, and FMO2.1 Homo sapiens etionamide S-oxide + NADP+ + H2O
-
?
methimazole + NADPH + H+ + O2 low activity with FMO2.1, moderate activity with FMO3, high activity with FMO1 Homo sapiens methimazole S-oxide + NADP+ + H2O
-
?
thiacetazone + NADPH + H+ + O2 low activity with FMO1 and FMO3, high activity with FMO2.1 Homo sapiens thiacetazone S-oxide + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
FMO1
-
Homo sapiens
FMO2.1
-
Homo sapiens
FMO3
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.023
-
thiacetazone 9.5, 37°C, FMO3 Homo sapiens
0.038
-
Methimazole 9.5, 37°C, FMO1 Homo sapiens
0.043
-
Methimazole 9.5, 37°C, FMO3 Homo sapiens
0.085
-
thiacetazone 9.5, 37°C, FMO1 Homo sapiens
0.525
-
Methimazole 9.5, 37°C, FMO2.1 Homo sapiens
1.335
-
thiacetazone 9.5, 37°C, FMO2.1 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
FMO1 and FMO3 Homo sapiens
9.5
-
FMO2.1 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
7.5 9.5
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.0033
-
thiacetazone 9.5, 37°C, FMO3 Homo sapiens
0.0091
-
Methimazole 9.5, 37°C, FMO2.1 Homo sapiens
0.0132
-
thiacetazone 9.5, 37°C, FMO1 Homo sapiens
0.015
-
Methimazole 9.5, 37°C, FMO3 Homo sapiens
0.0469
-
Methimazole 9.5, 37°C, FMO1 Homo sapiens
0.238
-
thiacetazone 9.5, 37°C, FMO2.1 Homo sapiens