Cloned (Comment) | Organism |
---|---|
expression of FMO1, FMO2.1, and FMO3 in Spodoptera frugiperda Sf9 cell microsomes | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0058 | - |
thiacetazone | 9.5, 37°C, FMO2.1 | Homo sapiens | |
0.0063 | - |
thiacetazone | 9.5, 37°C, FMO1 | Homo sapiens | |
0.007 | - |
thiacetazone | 9.5, 37°C, FMO3 | Homo sapiens | |
0.0081 | - |
Methimazole | 9.5, 37°C, FMO1 | Homo sapiens | |
0.0293 | - |
Methimazole | 9.5, 37°C, FMO3 | Homo sapiens | |
0.5758 | - |
Methimazole | 9.5, 37°C, FMO2.1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q01740 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
etionamide + NADPH + H+ + O2 | substrate of FMO1, FMO3, and FMO2.1 | Homo sapiens | etionamide S-oxide + NADP+ + H2O | - |
? | |
methimazole + NADPH + H+ + O2 | low activity with FMO2.1, moderate activity with FMO3, high activity with FMO1 | Homo sapiens | methimazole S-oxide + NADP+ + H2O | - |
? | |
thiacetazone + NADPH + H+ + O2 | low activity with FMO1 and FMO3, high activity with FMO2.1 | Homo sapiens | thiacetazone S-oxide + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FMO1 | - |
Homo sapiens |
FMO2.1 | - |
Homo sapiens |
FMO3 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.023 | - |
thiacetazone | 9.5, 37°C, FMO3 | Homo sapiens | |
0.038 | - |
Methimazole | 9.5, 37°C, FMO1 | Homo sapiens | |
0.043 | - |
Methimazole | 9.5, 37°C, FMO3 | Homo sapiens | |
0.085 | - |
thiacetazone | 9.5, 37°C, FMO1 | Homo sapiens | |
0.525 | - |
Methimazole | 9.5, 37°C, FMO2.1 | Homo sapiens | |
1.335 | - |
thiacetazone | 9.5, 37°C, FMO2.1 | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
FMO1 and FMO3 | Homo sapiens |
9.5 | - |
FMO2.1 | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7.5 | 9.5 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0033 | - |
thiacetazone | 9.5, 37°C, FMO3 | Homo sapiens | |
0.0091 | - |
Methimazole | 9.5, 37°C, FMO2.1 | Homo sapiens | |
0.0132 | - |
thiacetazone | 9.5, 37°C, FMO1 | Homo sapiens | |
0.015 | - |
Methimazole | 9.5, 37°C, FMO3 | Homo sapiens | |
0.0469 | - |
Methimazole | 9.5, 37°C, FMO1 | Homo sapiens | |
0.238 | - |
thiacetazone | 9.5, 37°C, FMO2.1 | Homo sapiens |