1.1.1.56: ribitol 2-dehydrogenase

This is an abbreviated version, for detailed information about ribitol 2-dehydrogenase, go to the full flat file.

Reaction

ribitol
+
NAD+
=
D-ribulose
+
NADH
+
H+

Synonyms

adonitol dehydrogenase, NAD+-dependent ribitol dehydrogenase, RDH, ribitol dehydrogenase A, ribitol dehydrogenase B, ribitol dehydrogenase D, ribitol-specific dehydrogenase, ribitol: NAD+ 2-oxidoreductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.56 ribitol 2-dehydrogenase

General Stability

General Stability on EC 1.1.1.56 - ribitol 2-dehydrogenase

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
freezing and thawing causes 30-40% decrease of mutant B enzyme activity
-
freezing and thawing causes 5-8% decrease of wild type enzyme activity
-
half life in crude extract at 55°C mutant B: 6 min
-
half life in crude extract at 55°C mutant D: 30 min
-
half life in crude extract at 55°C wild type: 20 min
-
NAD+ improves stability and reverses inhibition
-
repeated freezing and thawing results in extensive activity loss
-
unstable in dilute solutions
-