1.1.1.53: 3alpha(or 20beta)-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 3alpha(or 20beta)-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

androstan-3alpha,17beta-diol
+
NAD+
=
17beta-hydroxyandrostan-3-one
+
NADH
+
H+

Synonyms

(R)-20-hydroxysteroid dehydrogenase, 20-hydroxysteroid dehydrogenase, 20beta-HSD, 20beta-HSD type 2, 20beta-hydroxysteroid dehydrogenase, 20HSD, 3-alpha hydroxysteroid dehydrogenase type 3, 3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase, 3alpha-HSD/CR, 3alpha-HSD3, 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase, carbonyl reductase-like 20beta-HSD, carbonyl reductase-like 20beta-hydroxysteroid dehydrogenase, carbonyl reductase/20beta-hydroxysteroid dehydrogenase A, carbonyl reductase/20beta-hydroxysteroid dehydrogenase B, cortisone reductase, CR/20beta-HSD, CR/20beta-HSD A, CR/20beta-HSD B, dehydrogenase, 20beta-hydroxy steroid, delta4-3-ketosteroid hydrogenase, NADH-20beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.53 3alpha(or 20beta)-hydroxysteroid dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.53 - 3alpha(or 20beta)-hydroxysteroid dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
11alpha-hemisuccinyloxyprogesterone + NADH
?
show the reaction diagram
-
-
-
-
?
17-hydroxy-3,11,20-trioxo-4-pregnen-21-oate + NADH
17,20-dihydroxy-3,11-dioxo-4-pregnen-21-oate + NAD+
show the reaction diagram
-
-
-
-
?
17-hydroxy-3,20-dioxo-4-pregnen-21-oate + NADH
17,20-dihydroxy-4-pregnen-3-one-21-oate + NAD+
show the reaction diagram
-
-
-
-
?
17-hydroxyprogesterone + NADH
?
show the reaction diagram
-
-
-
-
?
17-hydroxyprogesterone + NADPH
17,20-beta-dihydroxy-4-pregnene-3-one
show the reaction diagram
-
-
-
-
?
17alpha,20beta-dihydroxypregn-4-ene-3-one + NADP+
17alpha-hydroxypregn-4-en-3,20-dione + NADPH
show the reaction diagram
-
-
-
-
?
17alpha-hydroxy-3,20-dioxo-4-pregnen-21-oate + NADH
17,20alpha-dihydroxy-4-pregnen-3-one-21-oate + NAD+
show the reaction diagram
17alpha-hydroxypregnenolone + NADPH
3beta,17alpha,20beta-trihydroxypregn-5-ene + NADP+
show the reaction diagram
-
i.e. 3beta,17alpha-dihydroxypregn-5-ene-20-one
-
-
?
17alpha-hydroxyprogesterone + NADPH
17alpha,20beta-dihydroxy-4-pregnen-3-one
show the reaction diagram
17alpha-hydroxyprogesterone + NADPH
17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+
show the reaction diagram
17alpha-hydroxyprogesterone + NADPH
17alpha,20beta-dihydroxy-pregn-4-ene-3-one (4-pregnene-17alpha,20beta-diol-3-one) + NADP+
show the reaction diagram
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+
show the reaction diagram
-
-
-
-
?
17beta-estradiol + NAD+
estrone + NADH
show the reaction diagram
4% of the activity with androsterone
-
-
?
17beta-[(1S)-1-hydroxy-2-propynyl]-androst-4-ene-3-one + NAD+
17beta-[1-oxo-2-propynyl]-androst-4-ene-3-one + NADH
show the reaction diagram
-
-
-
?
20alpha-hydroxyprogesterone + NAD+
? + NADH
show the reaction diagram
2% of the activity with androsterone
-
-
?
20beta-hydroxypregn-4-ene-3-one + NADP+
pregn-4-ene-3,20-dione + NADPH
show the reaction diagram
-
-
-
-
?
20beta-hydroxyprogesterone + NAD+
? + NADH
show the reaction diagram
69% of the activity with androsterone
-
-
?
21-acetoxyprogesterone + NADH
?
show the reaction diagram
-
-
-
-
?
21-hemisuccinyloxyprogesterone + NADH
?
show the reaction diagram
-
-
-
-
?
3,20-dioxo-4-pregnen-21-oic acid + NADH
20beta-hydroxy-3-oxo-4-pregnen-21-oic acid + NAD+
show the reaction diagram
3alpha,20beta-hydroxysteroid androstanes or pregnane derivatives + NAD(P)H
?
show the reaction diagram
3beta,17alpha,20alpha-trihydroxypregn-5-ene + NADP+
3beta,17alpha-dihydroxypregn-5-en-20-one + NADPH
show the reaction diagram
-
-
-
-
?
3beta,20alpha-dihydroxypregn-5-ene + NADP+
3beta-hydroxypregn-5-en-20-one + NADPH
show the reaction diagram
-
-
-
-
?
4-acetyl-N-(cyclohexylcarbamoyl)benzenesulfonamide + NADPH
hydroxyhexamide + NADP+
show the reaction diagram
4-nitrobenzaldehyde + NADPH
?
show the reaction diagram
-
-
-
-
?
4-pregnen-11beta,21-diol-3,20-dione + NADPH
4-pregnen-11beta,20alpha,21-triol-3-one + NADP+
show the reaction diagram
-
-
-
-
?
5alpha-androstan-17beta-ol-3-one + NAD(P)H + H+
5alpha-androstan-3alpha,17beta-diol + NAD(P)+
show the reaction diagram
5alpha-androstane-3,17-dione + NADPH
?
show the reaction diagram
-
-
-
-
?
5alpha-dihydrotestosterone + NADP+
5alpha-androstan-3alpha17beta-diol + NADPH + H+
show the reaction diagram
-
-
-
-
?
5alpha-dihydrotestosterone + NADPH
5alpha-androstan-3alpha,17beta-diol + NADP+
show the reaction diagram
14.4% of the activity with p-nitrobenzaldehyde
-
-
?
5alpha-pregnane-3,20-dione + NADH
?
show the reaction diagram
-
-
-
-
?
5alpha-pregnane-3,20-dione + NADPH
?
show the reaction diagram
-
-
-
-
?
5beta-androstan-17beta-ol-3-one + NAD(P)H
?
show the reaction diagram
-
i.e. 5beta-dihydrotestosterone
-
-
?
5beta-dihydrotestosterone + NADPH
5beta-androstan-3alpha,17beta-diol + NADP+
show the reaction diagram
9.2% of the activity with p-nitrobenzaldehyde
-
-
?
6beta-(bromoacetoxy)-progesterone + NADH
?
show the reaction diagram
-
-
-
-
?
9,10-phenanthrenequinone + NADPH
?
show the reaction diagram
-
-
-
-
?
androsterone + NAD+
? + NADH
show the reaction diagram
-
-
-
?
camphorquinone + NADPH + H+
camphorquinol + NADP+
show the reaction diagram
-
-
-
-
?
cortisone + NAD(P)H
17alpha,20beta,21-trihydroxy-pregn-4-ene-3,11-dione + NAD(P)+
show the reaction diagram
cortisone + NADPH + H+
20beta-hydroxycortisone + NADP+
show the reaction diagram
-
-
i.e. 4-pregnen-17alpha,20beta,21-triol-3,11-dione
-
?
cyclohexanone + NADPH
cyclohexanol + NADP+
show the reaction diagram
-
-
-
-
?
deoxycorticosterone + NADPH
20,21-dihydroxypregn-4-ene-3-one + NADP+
show the reaction diagram
deoxycortisol + NADPH
?
show the reaction diagram
-
-
-
-
?
epiandrosterone + NAD+
? + NADH
show the reaction diagram
3% of the activity with androsterone
-
-
?
hydrindantin + NADPH
?
show the reaction diagram
-
-
-
-
?
menadione + NADPH
?
show the reaction diagram
75% of the activity with p-nitrobenzaldehyde
-
-
?
methylglyoxal + NADPH
?
show the reaction diagram
-
-
-
-
?
p-nitrobenzaldehyde + NADPH
p-nitrobenzyl alcohol + NADP+
show the reaction diagram
-
-
-
?
phenylglyoxal + NADPH
?
show the reaction diagram
-
-
-
-
?
pregnenolone + NADPH
3beta,20beta-Dihydroxypregn-5-ene + NADP+
show the reaction diagram
-
i.e. 3-hydroxypregn-5-en-20-one
-
-
?
progesterone + NAD(P)H
20beta-hydroxy-pregn-4-ene-3-one + NAD(P)+
show the reaction diagram
progesterone + NADH
20beta-hydroxy-pregn-4-ene-3-one + NAD+
show the reaction diagram
22% of the activity with androsterone
-
-
?
progesterone + NADP+
20beta-hydroxy-pregn-4-ene-3-one + NADPH + H+
show the reaction diagram
-
-
-
-
?
progesterone + NADPH
20beta-hydroxy-pregn-4-ene-3-one + NADP+
show the reaction diagram
additional information
?
-