1.1.1.53: 3alpha(or 20beta)-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 3alpha(or 20beta)-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

androstan-3alpha,17beta-diol
+
NAD+
=
17beta-hydroxyandrostan-3-one
+
NADH
+
H+

Synonyms

(R)-20-hydroxysteroid dehydrogenase, 20-hydroxysteroid dehydrogenase, 20beta-HSD, 20beta-HSD type 2, 20beta-hydroxysteroid dehydrogenase, 20HSD, 3-alpha hydroxysteroid dehydrogenase type 3, 3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase, 3alpha-HSD/CR, 3alpha-HSD3, 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase, carbonyl reductase-like 20beta-HSD, carbonyl reductase-like 20beta-hydroxysteroid dehydrogenase, carbonyl reductase/20beta-hydroxysteroid dehydrogenase A, carbonyl reductase/20beta-hydroxysteroid dehydrogenase B, cortisone reductase, CR/20beta-HSD, CR/20beta-HSD A, CR/20beta-HSD B, dehydrogenase, 20beta-hydroxy steroid, delta4-3-ketosteroid hydrogenase, NADH-20beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.53 3alpha(or 20beta)-hydroxysteroid dehydrogenase

Reference

Reference on EC 1.1.1.53 - 3alpha(or 20beta)-hydroxysteroid dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tyrakowska, B.; Verhaert, R.M.D.; Hilhorst, R.; Veeger, C.
Enzyme kinetics in reversed micelles. 3. Behaviour of 20beta-hydroxysteroid dehydrogenase
Eur. J. Biochem.
187
81-88
1990
Streptomyces exfoliatus
Manually annotated by BRENDA team
Nakajin, S.; Ohno, S.; Shinoda, M.
20beta-Hydroxysteroid dehydrogenase of neonatal pig testis: purification and some properties
J. Biochem.
104
565-569
1988
Sus scrofa
Manually annotated by BRENDA team
Carrea, G.; Pasta, P.
Properties of immobilized subunits of 20beta-hydroxysteroid dehydrogenase
Methods Enzymol.
135
475-483
1987
Streptomyces exfoliatus
Manually annotated by BRENDA team
Vecchio, G.; Pasta, P.; Mazzola, G.; Carrea, G.
Multiparameter study of denaturation of 20beta-hydroxysteroid dehydrogenase by urea in the presence of stabilizing agents
Biochim. Biophys. Acta
914
122-126
1987
Streptomyces exfoliatus
Manually annotated by BRENDA team
Carrea, G.; Cremonesi, P.
Enzyme-catalyzed steroid transformations in water-organic solvent two-phase systems
Methods Enzymol.
136
150-157
1987
Streptomyces exfoliatus
-
Manually annotated by BRENDA team
Carrea, G.; Pasta, P.; Vecchio, G.
Effect of the lyotropic series of anions on denaturation and renaturation of 20beta-hydroxysteroid dehydrogenase
Biochim. Biophys. Acta
784
16-23
1984
Streptomyces exfoliatus
Manually annotated by BRENDA team
Strickler, R.C.; Covey, D.F.; Tobias, B.
Study of 3alpha, 20beta-hydroxysteroid dehydrogenase with an enzyme-generated affinity alkylator: dual enzyme activity at a single active site
Biochemistry
19
4950-4954
1980
Streptomyces exfoliatus
Manually annotated by BRENDA team
Sweet, F.; Samant, B.R.
Bifunctional enzyme activity at the same active site: study of 3alpha and 20beta activity by affinity alkylation of 3alpha, 20beta-hydroxysteroid dehydrogenase with 17-(bromoacetoxy)steroids
Biochemistry
19
978-986
1980
Streptomyces exfoliatus
Manually annotated by BRENDA team
Monder, C.
Reduction of steroidal 20-oxo-21-oic acids to steroidal 20-beta-hydroxy-21-oic acids by 20beta-hydroxysteroid dehydrogenase
J. Steroid Biochem.
9
1229-1231
1978
Streptomyces exfoliatus
Manually annotated by BRENDA team
Sweet, F.; Patrick, T.B.; Judd, M.
Substrate characteristics of progesterone-albumin conjugates with 20beta-hydroxysteroid dehydrogenase
Biochem. Biophys. Res. Commun.
83
187-194
1978
Streptomyces exfoliatus
Manually annotated by BRENDA team
Edwards, C.A.F.; Orr, J.C.
Comparison of the 3alpha-and 20beta-hydroxysteroid dehydrogenase activities of the cortisone reductase of Streptomyces hydrogenans
Biochemistry
17
4370-4376
1978
Streptomyces exfoliatus
Manually annotated by BRENDA team
Szymanski, E.S.; Furfine, C.S.
20beta-Hydroxysteroid oxidoreductase. Kinetics and binding of corticosteroids and corticosteroid-21-aldehydes
J. Biol. Chem.
252
205-211
1977
Streptomyces exfoliatus
Manually annotated by BRENDA team
Hubner, H.J.; Sahrholz, F.G.
20beta-hydroxy-steroid-dehydrogenase II. Darstellung und Kristallisation
Biochem. Z.
333
95-105
1960
Streptomyces exfoliatus
-
Manually annotated by BRENDA team
Lynn, W.S.; Brown, R.H.
The conversion of progesterone to androgens by testes
J. Biol. Chem.
232
1015-1030
1958
Cavia porcellus
Manually annotated by BRENDA team
Ohno, S.; Nakajin, S.; Shinoda, M.
20beta-Hydroxysteroid dehydrogenase of neonatal pig testis: 3alpha/beta-hydroxysteroid dehydrogenase activities catalyzed by highly purified enzyme
J. Steroid Biochem. Mol. Biol.
38
787-794
1991
Sus scrofa
Manually annotated by BRENDA team
Ohno, S.; Nakajin, S.; Shinoda, M.
20beta-Hydroxysteroid dehydrogenase of neonatal pig testis: reverse catalytic (oxidation) reaction
Chem. Pharm. Bull.
39
972-975
1991
Sus scrofa
Manually annotated by BRENDA team
Blomquist, C.H.
The molecular weight and substrate specificity of 20beta-hydroxysteroid dehydrogenase from Streptomyces hydrogenans
Arch. Biochem. Biophys.
159
590-595
1973
Streptomyces exfoliatus
-
Manually annotated by BRENDA team
Krook, M.; Prozorovski, V.; Atrian, S.; Gonzalez-Duarte, R.; Jörnvall, H.
Short-chain dehydrogenases. Proteolysis and chemical modification of prokaryotic 3alpha/20beta-hydroxysteroid, insect alcohol and human 15-hydroxyprostaglandin dehydrogenase
Eur. J. Biochem.
209
233-239
1992
Streptomyces exfoliatus
Manually annotated by BRENDA team
Takada, H.; Otagiri, M.; Imamura, Y.
20beta-Hydroxysteroid dehydrogenase catalyzes ketone-reduction of acetohexamide, an oral antidiabetic drug, in liver microsomes of adult male rats
J. Pharmacol. Exp. Ther.
287
504-507
1998
Rattus norvegicus
Manually annotated by BRENDA team
Takada, H.; Uchida, A.; Kamizono, R.; Otagiri, M.; Imamura, Y.
Further studies on 20beta-hydroxysteroid dehydrogenase with carbonyl reductase-like activity present in liver microsomes of male rats
Life Sci.
67
2075-2082
2000
Rattus norvegicus
Manually annotated by BRENDA team
Ohno, S.; Nakajin, S.; Shinoda, M.
Ontogeny of testicular steroid dehydrogenase enzymes in pig (3alpha/beta-, 20alpha- and 20beta-): evidence for two forms of 3alpha/beta-hydroxysteroid dehydrogenase
J. Steroid Biochem. Mol. Biol.
42
17-21
1992
Sus scrofa
Manually annotated by BRENDA team
Adachi, S.; Nagahama, Y.
Involvement of pH in the enhancement of 20beta-hydroxysteroid dehydrogenase activity in isolated granulosa cell layers from ovarian follicles of salmonid fishes
Biomed. Res.
11
327-335
1990
Oncorhynchus masou rhodurus, Oncorhynchus mykiss
-
Manually annotated by BRENDA team
Tanaka, M.; Ohno, S.; Adachi, S.; Nakajin, S.; Shinoda, M.; Nagahama, Y.
Pig testicular 20beta-hydroxysteroid dehydrogenase exhibits carbonyl reductase-like structure and activity
J. Biol. Chem.
267
13451-13455
1992
Sus scrofa
Manually annotated by BRENDA team
Guan, G.; Todo, T.; Tanaka, M.; Young, G.; Nagahama, Y.
Isoleucine-15 of rainbow trout carbonyl reductase-like 20beta-hydroxysteroid dehydrogenase is critical for coenzyme (NADPH) binding
Proc. Natl. Acad. Sci. USA
97
3079-3083
2000
Oncorhynchus mykiss
Manually annotated by BRENDA team
Vizziano, D.; Fostier, A.; Le Gac, F.; Loir, M.
20beta-Hydroxysteroid dehydrogenase activity in nonflagellated germ cells of rainbow trout testis
Biol. Reprod.
54
1-7
1996
Oncorhynchus mykiss
Manually annotated by BRENDA team
Ghosh, D.; Erman, M.; Wawrzak, Z.; Duax, W.L.; Pangborn, W.
Mechanism of inhibition of 3alpha, 20beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor
Curr. Biol.
2
973-980
1994
Streptomyces exfoliatus
Manually annotated by BRENDA team
Ghosh, D.; Wawrzak, Z.; Weeks, C.M.; Duax, W.L.; Erman, M.
The refined three-dimensional structure of 3alpha,20beta-hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases
Structure
2
629-640
1994
Streptomyces exfoliatus
Manually annotated by BRENDA team
Kazeto, Y.; Adachi, S.; Yamauchi, K.
20beta-hydroxysteroid dehydrogenase of the japanes eel ovary: its cellular localization and changes in the enzymatic acitvity during sexual maturation
Gen. Comp. Endocrinol.
122
109-115
2001
Anguilla japonica
Manually annotated by BRENDA team
Senthilkumaran, B.; Sudhakumari, C.C.; Chang, X.T.; Kobayashi, T.; Oba, Y.; Guan, G.; Yoshiura, Y.; Yoshikuni, M.; Nagahama, Y.
Ovarian carbonyl reductase-like 20beta-hydroxysteroid dehydrogenase shows distinct surge in messenger RNA expression during natural and gonadotropin-induced meiotic maturation in Nile tilapia
Biol. Reprod.
67
1080-1086
2002
Oreochromis niloticus, Oreochromis niloticus (Q8UVJ2)
Manually annotated by BRENDA team
Wang, Y.; Ge, W.
Cloning of zebrafish ovarian carbonyl reductase-like 20 beta-hydroxysteroid dehydrogenase and characterization of its spatial and temporal expression
Gen. Comp. Endocrinol.
127
209-216
2002
Danio rerio
Manually annotated by BRENDA team
Yang, J.K.; Park, M.S.; Waldo, G.S.; Suh, S.W.
Directed evolution approach to a structural genomics project: Rv2002 from Mycobacterium tuberculosis
Proc. Natl. Acad. Sci. USA
100
455-460
2003
Mycobacterium tuberculosis, Mycobacterium tuberculosis (P9WGT1), Mycobacterium tuberculosis H37Rv (P9WGT1)
Manually annotated by BRENDA team
Sreenivasulu, G.; Swapna, I.; Rasheeda, M.K.; Ijiri, S.; Adachi, S.; Thangaraj, K.; Senthilkumaran, B.
Expression of 20beta-hydroxysteroid dehydrogenase and P450 17alpha-hydroxylase/c17-20 lyase during hCG-induced in vitro oocyte maturation in snake head murrel Channa striatus
Fish Physiol. Biochem.
31
227-230
2006
Channa striata, Gallus gallus
Manually annotated by BRENDA team
Nakamura, I.; Evans, J.C.; Kusakabe, M.; Nagahama, Y.; Young, G.
Changes in steroidogenic enzyme and steroidogenic acute regulatory protein messenger RNAs in ovarian follicles during ovarian development of rainbow trout (Oncorhynchus mykiss)
Gen. Comp. Endocrinol.
144
224-231
2005
Oncorhynchus mykiss
Manually annotated by BRENDA team
Albertsson, E.; Kling, P.; Gunnarsson, L.; Larsson, D.G.; Foerlin, L.
Proteomic analyses indicate induction of hepatic carbonyl reductase/20beta-hydroxysteroid dehydrogenase B in rainbow trout exposed to sewage effluent
Ecotoxicol. Environ. Safety
68
33-39
2007
Oncorhynchus mykiss, Oncorhynchus mykiss (Q9PT36)
Manually annotated by BRENDA team
Hoffmann, F.; Sotriffer, C.; Evers, A.; Xiong, G.; Maser, E.
Understanding oligomerization in 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni: an in silico approach and evidence for an active protein
J. Biotechnol.
129
131-139
2007
Comamonas testosteroni
Manually annotated by BRENDA team
Mittelholzer, C.; Andersson, E.; Consten, D.; Hirai, T.; Nagahama, Y.; Norberg, B.
20 beta-hydroxysteroid dehydrogenase and CYP19A1 are differentially expressed during maturation in Atlantic cod (Gadus morhua)
J. Mol. Endocrinol.
39
319-328
2007
Gadus morhua (A8CZB9)
Manually annotated by BRENDA team
Sreenivasulu, G.; Senthilkumaran, B.
New evidences for the involvement of 20beta-hydroxysteroid dehydrogenase in final oocyte maturation of air-breathing catfish
Gen. Comp. Endocrinol.
163
259-269
2009
Clarias gariepinus
Manually annotated by BRENDA team
Tokarz, J.; Mindnich, R.; Norton, W.; Moeller, G.; Hrabe de Angelis, M.; Adamski, J.
Discovery of a novel enzyme mediating glucocorticoid catabolism in fish: 20beta-hydroxysteroid dehydrogenase type 2
Mol. Cell. Endocrinol.
349
202-213
2012
Danio rerio
Manually annotated by BRENDA team
Tokarz, J.; Norton, W.; Möller, G.; Hrabe de Angelis, M.; Adamski, J.
Zebrafish 20beta-hydroxysteroid dehydrogenase type 2 is important for glucocorticoid catabolism in stress response
PLoS ONE
8
e54851
2013
Danio rerio
Manually annotated by BRENDA team
Zhang, B.; Zhu, D.; Hu, X.; Zhou, M.; Shang, P.; Lin, S.
Human 3-alpha hydroxysteroid dehydrogenase type 3 (3alpha-HSD3): The V54L mutation restricting the steroid alternative binding and enhancing the 20alpha-HSD activity
J. Steroid Biochem. Mol. Biol.
141
135-143
2014
Homo sapiens
Manually annotated by BRENDA team