1.1.1.248: salutaridine reductase (NADPH)

This is an abbreviated version, for detailed information about salutaridine reductase (NADPH), go to the full flat file.

Reaction

salutaridinol
+
NADP+
=
salutaridine
+
NADPH
+
H+

Synonyms

More, reductase, salutaridine 7-, SalR, salutaridine 7-reductase, salutaridine reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.248 salutaridine reductase (NADPH)

Reference

Reference on EC 1.1.1.248 - salutaridine reductase (NADPH)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gerardy, R.; Zenk, M.H.
Purification and characterization of salutaridine:NADPH 7-oxidoreductase from Papaver somniferum
Phytochemistry
34
125-132
1993
no activity in Papaver alpinum, no activity in Papaver atlanticum, no activity in Papaver dubium, no activity in Papaver feddei, no activity in Papaver lateritium, no activity in Papaver oreophilum, no activity in Papaver orientale, no activity in Papaver persicum, no activity in Papaver pilosum, no activity in Papaver rhoeas, no activity in Papaver rupifragum, no activity in Papaver strigosum, no activity in Papaver tauricula, no activity in Papaver triniifolium, Papaver bracteatum, Papaver somniferum
-
Manually annotated by BRENDA team
Ziegler, J.; Voigtlaender, S.; Schmidt, J.; Kramell, R.; Miersch, O.; Ammer, C.; Gesell, A.; Kutchan, T.M.
Comparative transcript and alkaloid profiling in Papaver species identifies a short chain dehydrogenase/reductase involved in morphine biosynthesis
Plant J.
48
177-192
2006
Papaver somniferum, Papaver somniferum (Q071N0), Papaver somniferum salR (Q071N0)
Manually annotated by BRENDA team
Geissler, R.; Brandt, W.; Ziegler, J.
Molecular modeling and site-directed mutagenesis reveal the benzylisoquinoline binding site of the short-chain dehydrogenase/reductase salutaridine reductase
Plant Physiol.
143
1493-1503
2007
Papaver bracteatum (A4UHT7), Papaver bracteatum
Manually annotated by BRENDA team
Ziegler, J.; Brandt, W.; Geissler, R.; Facchini, P.J.
Removal of substrate inhibition and increase in maximal velocity in the short chain dehydrogenase/reductase salutaridine reductase involved in morphine biosynthesis
J. Biol. Chem.
284
26758-26767
2009
Papaver somniferum (Q071N0)
Manually annotated by BRENDA team
Ziegler, J.; Facchini, P.J.; Geissler, R.; Schmidt, J.; Ammer, C.; Kramell, R.; Voigtlaender, S.; Gesell, A.; Pienkny, S.; Brandt, W.
Evolution of morphine biosynthesis in opium poppy
Phytochemistry
70
1696-1707
2009
Papaver arenarium, Papaver bracteatum (A4UHT7), Papaver pilosum, Papaver pyrenaicum, Papaver somniferum
Manually annotated by BRENDA team
Kempe, K.; Higashi, Y.; Frick, S.; Sabarna, K.; Kutchan, T.M.
RNAi suppression of the morphine biosynthetic gene salAT and evidence of association of pathway enzymes
Phytochemistry
70
579-589
2009
Papaver somniferum
Manually annotated by BRENDA team
Higashi, Y.; Smith, T.J.; Jez, J.M.; Kutchan, T.M.
Crystallization and preliminary X-ray diffraction analysis of salutaridine reductase from the opium poppy Papaver somniferum
Acta Crystallogr. Sect. F
66
163-166
2010
Papaver somniferum, Papaver somniferum (Q071N0)
Manually annotated by BRENDA team
Wijekoon, C.P.; Facchini, P.J.
Systematic knockdown of morphine pathway enzymes in opium poppy using virus-induced gene silencing
Plant J.
69
1052-1063
2012
Papaver somniferum
Manually annotated by BRENDA team
Higashi, Y.; Kutchan, T.M.; Smith, T.J.
Atomic structure of salutaridine reductase from the opium poppy (Papaver somniferum)
J. Biol. Chem.
286
6532-6541
2011
Papaver somniferum, Papaver somniferum (Q071N0)
Manually annotated by BRENDA team