Literature summary for 1.1.1.248 extracted from

Fossati, E.; Narcross, L.; Ekins, A.; Falgueyret, J.P.; Martin, V.J.
Synthesis of morphinan alkaloids in Saccharomyces cerevisiae (2015), PLoS ONE, 10, e0124459.

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Application

Application	Comment	Organism
synthesis	the Papaper somniferum enzymes salutaridine synthase (SAS), salutaridine reductase (SAR) and salutaridinol acetyltransferase (SAT) are functionally co-expressed in Saccharomyces cerevisiae and optimization of the pH conditions allows for productive spontaneous rearrangement of salutaridinol-7-O-acetate and synthesis of thebaine from (R)-reticuline. Upon reconstitution of a 7-gene pathway for the production of codeine and morphine from (R)-reticuline, activity of salutaridine reductase and codeine-O-demethylase likely limit flux to morphine synthesis	Papaver somniferum

Organism

Organism	UniProt	Comment	Textmining
Papaver somniferum	KP400665	-	-

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Release 2023.1 (January 2023)