1.1.1.248: salutaridine reductase (NADPH)

This is an abbreviated version, for detailed information about salutaridine reductase (NADPH), go to the full flat file.

Reaction

salutaridinol
+
NADP+
=
salutaridine
+
NADPH
+
H+

Synonyms

More, reductase, salutaridine 7-, SalR, salutaridine 7-reductase, salutaridine reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.248 salutaridine reductase (NADPH)

Substrates Products

Substrates Products on EC 1.1.1.248 - salutaridine reductase (NADPH)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
salutaridine + NAD(P)H + H+
(7S)-salutaridinol + NAD(P)+
show the reaction diagram
NADPH is the highly preferred cofactor, the enzyme shows high substrate specificity, no activity with tropinone, (2)-menthone, codeinone and dehydroreticulinium ion, or nordehydroreticuline. Asp152, Ser180, Tyr236, and Lys240 are involved in the proton transfer system for the reduction of salutaridine, substrate-active site binding structure, overview
the enzyme produces only the (7S)-salutaridinol stereoisomer as product, not the stereoisomer 7-epi-salutaridinol
-
r
salutaridine + NADPH + H+
(7S)-salutaridinol + NADP+
show the reaction diagram
salutaridine + NADPH + H+
salutaridinol + NADP+
show the reaction diagram
additional information
?
-