1.1.1.119: glucose 1-dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about glucose 1-dehydrogenase (NADP+), go to the full flat file.
Word Map on EC 1.1.1.119
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1.1.1.119
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photorespiration
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megaterium
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synthesis
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photorespiratory
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2-ketogluconate
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biocatalysis
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analysis
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industry
- 1.1.1.119
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photorespiration
- megaterium
- synthesis
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photorespiratory
- 2-ketogluconate
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biocatalysis
- analysis
- industry
Reaction
Synonyms
beta-D-glucose: NAD(P) 1-oxidoreductase, dehydrogenase, glucose (nicotinamide adenine dinucleotide phosphate), GDH, GlcDH, GlcDH 2, glucose dehydrogenase, glucose-1-dehydrogenase, glucose-1-DH, halophilic glucose dehydrogenase, Hm GDH, NAD(P)+ glucose dehydrogenase, NAD(P)-dependent GDH, NADP-dependent glucose dehydrogenase, NADP-glucose-1-dehydrogenase, NADP-linked aldohexose dehydrogenase, nicotinamide adenine dinucleotide (phosphate)-dependent glucose-1-dehydrogenase, nicotinamide adenine dinucleotide phosphate-linked aldohexose dehydrogenase, STK_17040
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Substrates Products
Substrates Products on EC 1.1.1.119 - glucose 1-dehydrogenase (NADP+)
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REACTION DIAGRAM
2-amino-2-deoxy-D-mannose + NADP+
2-amino-2-deoxy-D-mannono-1,5-lactone + NADPH
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2-deoxy-D-glucose + NADP+
2-deoxy-D-glucono-1,5-lactone + NADPH + H+
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beta-D-galactose + NADP+
D-galactono-1,5-lactone + NADPH
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beta-D-glucose + NAD+
D-glucono-1,5-lactone + NADH + H+
the enzyme has a strong preference for NADP+ over NAD+
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D-glucose + NAD(P)+
D-glucono-1,5-lactone + NAD(P)H + H+
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D-glucose + polyethylene glycol(MW 20000)-N6-(2-aminoethyl)-NADP+
D-glucono-1,5-lactone + polyethylene glycol(MW 20000)-N6-(2-aminoethyl)-NADPH + H+
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additional information
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reduction of C=N bonds with good levels of conversion (more than 50%) and excellent enantioselectivity (up to more than 99% enantiomeric excess) by glucose dehydrogenase represents a promiscuous catalytic activity of this enzyme
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activity with NAD+ is 26% of the activity with NADP+
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beta-D-glucose + NAD+
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activity with NAD+ is 26% of the activity with NADP+
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activity with NAD+ is 26% of the activity with NADP+. The enzyme shows also activity with D-fucose and NADP+ (at 18% compared to the activity with beta-D-glucose and NADP+), with D-galactose and NADP+ (at 13% compared to the activity with beta-D-glucose and NADP+), with D-xylose and NAD+ (at 79% compared to the activity with beta-D-glucose and NADP+), with D-xylose and NADP+ (at 88% compared to the activity with beta-D-glucose and NADP+)
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beta-D-glucose + NADP+
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activity with NAD+ is 26% of the activity with NADP+. The enzyme shows also activity with D-fucose and NADP+ (at 18% compared to the activity with beta-D-glucose and NADP+), with D-galactose and NADP+ (at 13% compared to the activity with beta-D-glucose and NADP+), with D-xylose and NAD+ (at 79% compared to the activity with beta-D-glucose and NADP+), with D-xylose and NADP+ (at 88% compared to the activity with beta-D-glucose and NADP+)
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D-glucono-1,5-lactone + NADPH + H+
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beta-D-glucose + NADP+
D-glucono-1,5-lactone + NADPH + H+
the enzyme has a strong preference for NADP+ over NAD+
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D-glucono-1,5-lactone + 1,N6-ethanoadenine-NADPH
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D-glucose + 1,N6-ethanoadenine-NADP+
D-glucono-1,5-lactone + 1,N6-ethanoadenine-NADPH
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D-glucono-1,5-lactone + N1-(2-aminoethyl)-NADPH
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D-glucose + N1-(2-aminoethyl)-NADP+
D-glucono-1,5-lactone + N1-(2-aminoethyl)-NADPH
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D-glucono-1,5-lactone + N6-(2-aminoethyl)-NADPH
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D-glucose + N6-(2-aminoethyl)-NADP+
D-glucono-1,5-lactone + N6-(2-aminoethyl)-NADPH
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D-glucose + NADP+
D-glucono-1,5-lactone + NADPH + H+
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4% of the reverse reaction when assayed with D-glucono-1,5-lactone and NADPH at neutral or weak alkaline pH
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D-glucose + NADP+
D-glucono-1,5-lactone + NADPH + H+
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unphosphorylated glucose as substrate
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D-glucose + NADP+
D-glucono-1,5-lactone + NADPH + H+
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D-glucose + NADP+
D-glucono-1,5-lactone + NADPH + H+
the enzyme prefers NADP+ over NAD+ as the cofactor. It shows a larger Km value for NAD+ (4.5 mM) than for NADP+ (0.12 mM) at 80°C. At 25°C the Km values are 0.069 mM for NAD+ and 0.0059 mM for NADP+
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D-glucose + NADP+
D-glucono-1,5-lactone + NADPH + H+
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D-glucose + NADP+
D-glucono-1,5-lactone + NADPH + H+
the enzyme prefers NADP+ over NAD+ as the cofactor. It shows a larger Km value for NAD+ (4.5 mM) than for NADP+ (0.12 mM) at 80°C. At 25°C the Km values are 0.069 mM for NAD+ and 0.0059 mM for NADP+
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