1.1.1.102: 3-dehydrosphinganine reductase

This is an abbreviated version, for detailed information about 3-dehydrosphinganine reductase, go to the full flat file.

Reaction

sphinganine
+
NADP+
=
3-dehydrosphinganine
+
NADPH
+
H+

Synonyms

3-KDS reductase, 3-ketodihydrosphingosine reductase, 3-ketosphinganine reductase, 3-oxosphinganine reductase, 3-oxosphinganine:NADPH oxidoreductase, 3KDSR, D-3-dehydrosphinganine reductase, D-3-oxosphinganine reductase, D-3-oxosphinganine:B-NADPH oxidoreductase, DSR, FVT-1, Fvt1, h-FTV-1, KDS reductase, Ksr1p, KsrA, m-FTV-1, More, TSC10, TSC10A, Tsc10p

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.102 3-dehydrosphinganine reductase

Cloned

Cloned on EC 1.1.1.102 - 3-dehydrosphinganine reductase

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli, Myc-His-tagged enzyme
-
expression in yeast cells
FVT1 expressed in CHO cells or yeast
-
gene 3kdsr, DNA and amino acid sequence determination and analysis, sequence comparisons, quantitative expression analysis
S4SCP5
gene ksr1, DNA and amino acid sequence determination and analysis, functional expression in Escherichia coli strain JM109(DE3)
-
gene ksrA, DNA and amino acid sequence determination and analysis, functional expression in Escherichia coli strain JM109(DE3)
-
gene tsc10, expression of mutant tscDELTA38 in Escherichia coli strain BL21(DE3)
-
genes At3g06060/TSC10A and At5g19200/TSC10B, i.e. tsc10A and tsc10B, expression of GFP-TSC10A and GFP-TSC10B in tsc10DELTA yeast mutant cells, heterologous expression of the two genes from Arabidopsis thaliana in 3-KDS reductase-deficient Saccharomyces cerevisiae mutant strain, tsc10DELTA, restores the enzyme activity
-
TSC10p expressed in CHO cells or yeast
-