1.1.1.102: 3-dehydrosphinganine reductase

This is an abbreviated version, for detailed information about 3-dehydrosphinganine reductase, go to the full flat file.

Reaction

sphinganine
+
NADP+
=
3-dehydrosphinganine
+
NADPH
+
H+

Synonyms

3-KDS reductase, 3-ketodihydrosphingosine reductase, 3-ketosphinganine reductase, 3-oxosphinganine reductase, 3-oxosphinganine:NADPH oxidoreductase, 3KDSR, D-3-dehydrosphinganine reductase, D-3-oxosphinganine reductase, D-3-oxosphinganine:B-NADPH oxidoreductase, DSR, FVT-1, Fvt1, h-FTV-1, KDS reductase, Ksr1p, KsrA, m-FTV-1, More, TSC10, TSC10A, Tsc10p

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.102 3-dehydrosphinganine reductase

KM Value

KM Value on EC 1.1.1.102 - 3-dehydrosphinganine reductase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.03
(S)-2-amino-1-hydroxyeicosane-3-one
-
-
0.015
(S)-2-amino-1-hydroxyoctadecane-3-one
-
-
0.009
3-dehydrosphinganine
-
pH 7.5, recombinant enzyme
0.003
3-ketodihydrosphingosine
pH 7.5, 37C
0.028
NADPH
pH 7.5, 37C
additional information
additional information
-
binding kinetics of substrate analogues with shorter chain lengths
-