EC Number   |
Protein Variants |
Reference |
|---|
   3.4.24.80 | C127S |
site-directed mutagenesis, no significant difference in activity is observed for the mutant C127S and the wild-type MT1-MMP |
755009 |
| 3.4.24.80 | C574A |
inefficient in stimulating cell adhesion, migration and invasion, mutation negatively affects cell adhesion |
638807 |
| 3.4.24.80 | C574S |
substitution in the cytoplasmic domain, reduction of pro-MMP2 activation, no up-regulation of VEGF expression |
669211 |
| 3.4.24.80 | E240A |
a catalytically inactive MT1-MMP mutant |
709058 |
| 3.4.24.80 | E240A |
catalytically inactive |
638812, 680884 |
| 3.4.24.80 | E240A |
catalytically inactive, inefficient in stimulating cell migration and invasion |
638807 |
| 3.4.24.80 | E240A |
catalytically inert |
668966 |
| 3.4.24.80 | E240A |
expressed on transfected cell surface but fails to activate pMMP-2 |
669212 |
| 3.4.24.80 | E240A |
inactive |
681866, 720437 |
| 3.4.24.80 | E240A |
inactive MMP14 mutant |
754591 |
