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Literature summary for 3.4.24.80 extracted from
- Membrane-type 1 matrix metalloproteinase stimulates cell migration through epidermal growth factor receptor transactivation (2007), Mol. Cancer Res., 5, 569-583.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | sphingosine-1-phosphate is necessary for the transactivation of the epidermal growth factor receptor by MTI-MMP | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E240A | inactive | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| TIMP-2 | potent inhibitor | Homo sapiens | |
| TIMP-3 | potent inhibitor | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| epidermal growth factor receptor + H2O | the enzyme plays a role in transactivation | Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| membrane-type 1 matrix metalloproteinase | - |
Homo sapiens |
| MT1-MMP | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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