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Protein Variants:
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EC Number
Protein Variants
Commentary
Reference
3.1.3.56
C939S
eliminates isoprenylation of enzyme which reduces activity towards phosphatidylinositol 4,5-bisphosphate
646393
3.1.3.56
C409S
predominantly soluble
646395
3.1.3.56
DELTA407-411
predominantly soluble
646395
3.1.3.56
R343A
increased Km and dramatic loss of activity
646396
3.1.3.56
R350A
increased Km
646396
3.1.3.56
C409S
decreased activity
646397
3.1.3.56
DELTA1-119
no significant influence on localization of enzyme
646399
3.1.3.56
DELTA1-311
no significant influence on localization of enzyme
646399
3.1.3.56
DELTA1-433
enzyme mainly in cytoplasm
646399
3.1.3.56
DELTA725-1001
enzyme exclusively cytoplasmic
646399
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