Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.56 extracted from

  • De Smedt, F.; Boom, A.; Pesesse, X.; Schiffmann, S.N.; Erneux, C.
    Post-translational modification of human brain type I inositol-1,4,5-trisphosphate 5-phosphatase by farnesylation (1996), J. Biol. Chem., 271, 10419-10424.
    View publication on PubMed
Search for more literature for 3.1.3.56

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-7 and CHO cells and Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
C409S predominantly soluble Homo sapiens
DELTA407-411 predominantly soluble Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane major part of activity is membrane bound Homo sapiens 16020
-
membrane major part of activity is membrane bound Rattus norvegicus 16020
-
soluble
-
 Homo sapiens
-
-
soluble
-
 Rattus norvegicus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
43000
-
 SDS-PAGE, type I enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-myo-inositol 1,4,5-trisphosphate + H2O Homo sapiens regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O Rattus norvegicus regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification farnesylation at Cys-409 Homo sapiens
side-chain modification farnesylation Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
recombinant enzymes from Escherichia coli using His-tag Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Homo sapiens D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Rattus norvegicus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Homo sapiens D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?