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Information on EC 3.1.3.56 - inositol-polyphosphate 5-phosphatase
for references in articles please use BRENDA:EC3.1.3.56
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EC Tree 3 Hydrolases
3.1 Acting on ester bonds
3.1.3 Phosphoric-monoester hydrolases
3.1.3.56 inositol-polyphosphate 5-phosphatase
IUBMB Comments
One mammalian isoform is known. This enzyme is distinguished from the family of enzymes classified under EC 3.1.3.36, phosphoinositide 5-phosphatase, by its inability to dephosphorylate inositol lipids.
The enzyme appears in viruses and cellular organisms
- 3.1.3.56
- phosphatidylinositol
- 1,4-bisphosphate
- 5ptases
-
oculocerebrorenal
- 3,4,5-trisphosphate
-
ptdins4,5p2
-
3hinositol
- 2,3-bisphosphoglycerate
- inpp5f
-
ptdins3,4,5p3
- medicine
- molecular biology
Reaction Schemes
showSynonyms
inpp5k, ins(1,4,5)p3 5-phosphatase, inositol polyphosphate-5-phosphatase, inpp5a, insp 5-ptase, insp3 5-phosphatase, pip3 phosphatase, at5ptase1, inositol polyphosphatase, 5pt13, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
5PTase
D-myo-inositol 1,4,5-triphosphate 5-phosphatase
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D-myo-inositol 1,4,5-trisphosphate 5-phosphatase
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D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase
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inosine triphosphatase
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inositol 1,4,5-triphosphate 5-phosphatase
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inositol 1,4,5-trisphosphate 5-monophosphatase
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inositol 1,4,5-trisphosphate 5-phosphatase
inositol 1,4,5-trisphosphate phosphatase
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inositol phosphate 5-phosphomonoesterase
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inositol polyphosphate 5-phosphatase
inositol polyphosphate-5-phosphatase
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inositol trisphosphate phosphomonoesterase
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inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase
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INPP5K
Ins(1,4,5)P3 5-phosphatase
Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase
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L-myo-inositol 1,4,5-trisphosphate-monoesterase
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myo-inositol-1,4,5-trisphosphate 5-phosphatase
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phosphatase, inosine tri-5PTASE
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protein-tyrosine phosphatase
PTP
SHIP2
Siw14
type I inositol-1,4,5-trisphosphate 5-phosphatase
additional information
inositol 1,4,5-trisphosphate 5-phosphatase
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Ins(1,4,5)P3 5-phosphatase
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additional information
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the enzyme belongs to the type I 5-phosphatase family, cf. EC 3.1.3.36, phosphoinositide 5-phosphatase
additional information
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cf. EC 3.1.3.36, phosphoinositide 5-phosphatase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate
D-myo-inositol 1,4,5-trisphosphate + H2O = D-myo-inositol 1,4-bisphosphate + phosphate
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1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate
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1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate
catalytic and kinetic reaction mechanism, substrate binding, overview
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1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate
catalytic and kinetic reaction mechanism, substrate binding, overview
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
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PATHWAY SOURCE
PATHWAYS
MetaCyc
1D-myo-inositol hexakisphosphate biosynthesis II (mammalian), D-myo-inositol (1,3,4)-trisphosphate biosynthesis, D-myo-inositol (1,4,5)-trisphosphate degradation
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SYSTEMATIC NAME
IUBMB Comments
1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase
One mammalian isoform is known. This enzyme is distinguished from the family of enzymes classified under EC 3.1.3.36, phosphoinositide 5-phosphatase, by its inability to dephosphorylate inositol lipids.
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CAS REGISTRY NUMBER
COMMENTARY
106283-14-1
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9082-57-9
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1,5-bisdiphosphoinositol 2,3,4,6-tetrakisphosphate + H2O
1-diphosphoinositol 2,3,4,6-tetrakisphosphate + phosphate
1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O
phosphatidylinositol 4-phosphate + phosphate
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O
1D-myo-inositol 1,2,3,4-tetrakisphosphate + phosphate
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Substrates: preferred substrate
Products: -
Products: -
?
1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O
1D-myo-inositol 1,2,4,6-tetrakisphosphate + phosphate
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Substrates: -
Products: -
Products: -
?
1D-myo-inositol 1,2,4,5-tetrakisphosphate + H2O
1D-myo-inositol 1,2,4-trisphosphate + phosphate
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Substrates: -
Products: -
Products: -
?
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
1D-myo-inositol 1,3,4-trisphosphate + phosphate
1D-myo-inositol 1,4,5,6-tetrakisphosphate + H2O
1D-myo-inositol 1,4,6-trisphosphate + phosphate
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Substrates: -
Products: -
Products: -
?
1D-myo-inositol 1,4,5-trisphosphate + H2O
1D-myo-inositol 1,4-disphosphate + phosphate
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Substrates: -
Products: -
Products: -
?
1D-myo-inositol 1,4,5-trisphosphate + H2O
myo-inositol 1,4-bisphosphate + phosphate
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Substrates: -
Products: -
Products: -
?
1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O
1D-myo-inositol 2,4,6-trisphosphate + phosphate
1D-myo-inositol 2,4,5-trisphosphate + H2O
1D-myo-inositol 2,4-bisphosphate + phosphate
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Substrates: preferred substrate
Products: -
Products: -
?
1D-myo-inositol 3,4,5-trisphosphate + H2O
1D-myo-inositol 3,4-bisphosphate + phosphate
Substrates: -
Products: -
Products: -
?
1D-myo-inositol 3,5-bisphosphate + H2O
1D-myo-inositol 3-phosphate + phosphate
Substrates: -
Products: -
Products: -
?
1D-myo-inositol 4,5,6-trisphosphate + H2O
1D-myo-inositol 4,6-bisphosphate + phosphate
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Substrates: -
Products: -
Products: -
?
3-hydroxybenzene 1,2,4-trisphosphate + H2O
2,3-dihydroxybenzene 1,4-bisphosphate + phosphate
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Substrates: this is the first example of its kind to illustrate that an unnatural aromatic polyphosphorylated molecule can be specifically dephosphorylated by type I Ins(1,4,5)P3 5-phosphatase. No reaction with benzene 1,2,4-trisphosphate
Products: -
Products: -
?
3-O-methylfluorescein phosphate + H2O
3-O-methylfluorescein + phosphate
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Substrates: -
Products: -
Products: -
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
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Substrates: -
Products: -
Products: -
?
5-diphosphoinositol 1,2,3,4,6-pentakisphosphate + H2O
myo-inositol hexakisphosphate + phosphate
5-diphosphoinositol 1,3,4,6-tetrakisphosphate + H2O
inositol-1,3,4,5,6-pentakisphosphate + phosphate
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Substrates: moderate to low activity
Products: -
Products: -
?
6-diphosphoinositol 1,2,3,4,5-pentakisphosphate + H2O
?
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Substrates: low activity
Products: -
Products: -
?
7-methyl-6-thioguanosine + H2O
7-methyl-6-thioguanine + ribose 1-phosphate
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Substrates: spectrophotometric continous coupled enzyme assay substrate
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
D-myo-inositol 1,4,5,6-tetrakisphosphate + H2O
D-myo-inositol 1,4,6-trisphosphate + phosphate
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Substrates: poor substrate
Products: -
Products: -
?
glycerophosphoinositol 4,5-bisphosphate + H2O
glycerophosphoinositol 4-phosphate + phosphate
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Substrates: at 13% of the rate of inositol 1,4,5-trisphosphate hydrolysis
Products: -
Products: -
?
inositol 1,2-cyclic 4,5-trisphosphate + H2O
?
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Substrates: poor substrate
Products: -
Products: -
?
inositol 4,5-bisphosphate + H2O
inositol 4-phosphate + phosphate
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Substrates: -
Products: -
Products: -
?
phosphatidyl-L-myo-inositol 3,4,5-trisphosphate + H2O
phosphatidylinositol 3,4-bisphosphate + phosphate
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Substrates: -
Products: -
Products: -
?
1,5-bisdiphosphoinositol 2,3,4,6-tetrakisphosphate + H2O
1-diphosphoinositol 2,3,4,6-tetrakisphosphate + phosphate
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Substrates: moderate activity
Products: -
Products: -
?
1,5-bisdiphosphoinositol 2,3,4,6-tetrakisphosphate + H2O
1-diphosphoinositol 2,3,4,6-tetrakisphosphate + phosphate
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Substrates: moderate activity
Products: -
Products: -
?
1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O
phosphatidylinositol 4-phosphate + phosphate
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Substrates: -
Products: -
Products: -
?
1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O
phosphatidylinositol 4-phosphate + phosphate
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Substrates: -
Products: -
Products: -
?
1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O
phosphatidylinositol 4-phosphate + phosphate
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Substrates: regulation of the 1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate level at membrane ruffels
Products: -
Products: -
?
1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O
phosphatidylinositol 4-phosphate + phosphate
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Substrates: -
Products: -
Products: -
?
1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O
phosphatidylinositol 4-phosphate + phosphate
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Substrates: -
Products: -
Products: -
?
1-diphosphoinositol 2,3,4,5,6-pentakisphosphate + H2O
?
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Substrates: low activity
Products: -
Products: -
?
1-diphosphoinositol 2,3,4,5,6-pentakisphosphate + H2O
?
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Substrates: low activity
Products: -
Products: -
?
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
1D-myo-inositol 1,3,4-trisphosphate + phosphate
Substrates: -
Products: -
Products: -
?
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
1D-myo-inositol 1,4,5-trisphosphate + H2O
1D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
1D-myo-inositol 1,4,5-trisphosphate + H2O
1D-myo-inositol 1,4-bisphosphate + phosphate
Substrates: specific for
Products: -
Products: -
?
1D-myo-inositol 1,4,5-trisphosphate + H2O
1D-myo-inositol 1,4-bisphosphate + phosphate
Substrates: absolutely specific for
Products: -
Products: -
?
1D-myo-inositol 1,4,5-trisphosphate + H2O
1D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
1D-myo-inositol 1,4,5-trisphosphate + H2O
1D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: 1D-myo-inositol 1,4,5-trisphosphate metabolism, regulation, overview
Products: -
Products: -
?
1D-myo-inositol 1,4,5-trisphosphate + H2O
1D-myo-inositol 1,4-bisphosphate + phosphate
Substrates: specific for
Products: -
Products: -
?
1D-myo-inositol 1,4,5-trisphosphate + H2O
1D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
1D-myo-inositol 1,4,5-trisphosphate + H2O
1D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: the enzyme is involved in Ins(1,4,5)P3-mediated Ca2+ signaling associated to PRIP-1, a Ins(1,4,5)P3-binding protein, overview
Products: -
Products: -
?
1D-myo-inositol 1,4,5-trisphosphate + H2O
1D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: the enzyme is involved in the metabolism of polyphosphoinisotide in cellular signalling
Products: -
Products: -
?
1D-myo-inositol 1,4,5-trisphosphate + H2O
1D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: recombinant purified enzyme expressed in Escherichia coli
Products: -
Products: -
?
1D-myo-inositol 1,4,5-trisphosphate + H2O
1D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O
1D-myo-inositol 2,4,6-trisphosphate + phosphate
-
Substrates: low activity
Products: -
Products: -
?
1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O
1D-myo-inositol 2,4,6-trisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
4-diphosphoinositol 1,2,3,5,6-pentakisphosphate + H2O
?
-
Substrates: low activity
Products: -
Products: -
?
4-diphosphoinositol 1,2,3,5,6-pentakisphosphate + H2O
?
-
Substrates: low activity
Products: -
Products: -
?
5-diphosphoinositol 1,2,3,4,6-pentakisphosphate + H2O
myo-inositol hexakisphosphate + phosphate
-
Substrates: best substrate
Products: -
Products: -
?
5-diphosphoinositol 1,2,3,4,6-pentakisphosphate + H2O
myo-inositol hexakisphosphate + phosphate
-
Substrates: best substrate
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: substrate for type I but not type II enzyme
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: product is precursor for inositol 1,3,4,5,6-pentiskphosphate via inositol 1,3,4,6-tetraiskphosphate
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: very poor substrate
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: product is precursor for inositol 1,3,4,5,6-pentiskphosphate via inositol 1,3,4,6-tetraiskphosphate
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: substrate for type I but not type II enzyme
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: at 8% of the rate of inositol 1,4,5-trisphosphate hydrolysis
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: type I and type II enzyme
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: product is precursor for inositol 1,3,4,5,6-pentiskphosphate via inositol 1,3,4,6-tetraiskphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
Frog
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
Frog
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
646372, 646377, 646379, 646382, 646385, 646389, 646392, 646393, 646395, 646396, 646397, 646398, 646403
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: involved in regulation of excitation-contraction coupling in skeletal muscle
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: involved in regulation of excitation-contraction coupling in skeletal muscle
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
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additional information
?
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Substrates: substrate specificity, no activity with 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate, 1D-myo-inositol 1,3,4,5-tetrakisphosphate, 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate, 1-phosphatidyl-1D-myo-inositol 5-phosphate, 1-phosphatidyl-1D-myo-inositol 4-phosphate, and 1-phosphatidyl-1D-myo-inositol 3-phosphate
Products: -
Products: -
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additional information
?
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Substrates: substrate specificity, no activity with 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate, 1D-myo-inositol 1,3,4,5-tetrakisphosphate, 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate, 1-phosphatidyl-1D-myo-inositol 5-phosphate, 1-phosphatidyl-1D-myo-inositol 4-phosphate, and 1-phosphatidyl-1D-myo-inositol 3-phosphate
Products: -
Products: -
?
additional information
?
-
-
Substrates: D-6-deoxy-myo-inositol 1,3,4,5-tetrakisphosphate are not hydrolyzed
Products: -
Products: -
?
additional information
?
-
-
Substrates: enzyme knockout results in decrease in nucleocytoplasmic inositol phosphate 6-/3-kinases Ipk2/Ipk1-dependent inositol hexakisphosphate synthesis, overview
Products: -
Products: -
?
additional information
?
-
-
Substrates: glycerophosphoinositol 4-phosphate and inositol 1,4-bisphosphate are not hydrolyzed
Products: -
Products: -
?
additional information
?
-
-
Substrates: glycerophosphoinositol 4,5-bisphosphate is not hydrolyzed
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme has multiple roles in cellular signalling and may regulate distinct pathways
Products: -
Products: -
?
additional information
?
-
-
Substrates: substrate specificity, no activity with 1D-myo-inositol 1,4,5-trisphosphate, 1-phosphatidyl-1D-myo-inositol 5-phosphate, 1D-myo-inositol 1,5-bisphosphate, and 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, overview
Products: -
Products: -
?
additional information
?
-
-
Substrates: enzyme only binds soluble inositol polyphosphates
Products: -
Products: -
?
additional information
?
-
Substrates: isofom SHIP2 is unable to dephosphorylate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme binds to PRIP-1, a Ins(1,4,5)P3-binding protein, via the protein's PH-domain, which inhibits the enzyme activity
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme shows high activity and exquisite specificity for the 5-diphosphate group of inositol diphosphates (5-PP-InsP), substrate-binding pocket structure analysis, overview. No activity with inositol hexakisphosphate, poor activity with 2-diphosphoinositol 1,3,4,5,6-pentakisphosphate and 3-diphosphoinositol 1,2,4,5,6-pentakisphosphate. Enzyme Siw14 also acts as protein tyrosine phosphatase, EC 3.1.3.48
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme shows high activity and exquisite specificity for the 5-diphosphate group of inositol diphosphates (5-PP-InsP), substrate-binding pocket structure analysis, overview. No activity with inositol hexakisphosphate, poor activity with 2-diphosphoinositol 1,3,4,5,6-pentakisphosphate and 3-diphosphoinositol 1,2,4,5,6-pentakisphosphate. Enzyme Siw14 also acts as protein tyrosine phosphatase, EC 3.1.3.48
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme has multiple roles in cellular signalling and may regulate distinct pathways
Products: -
Products: -
?
additional information
?
-
-
Substrates: substrate specificity, no activity with 1-phosphatidyl-1D-myo-inositol 5-phosphate, 1D-myo-inositol 1,5-bisphosphate, 1D-myo-inositol 1,3,5-trisphosphate, and with alpha-D-glucose 1-phosphate, D-glucose 6-phosphate, and alpha-D,L-glycerophosphate, overview
Products: -
Products: -
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O
phosphatidylinositol 4-phosphate + phosphate
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
1D-myo-inositol 1,3,4-trisphosphate + phosphate
1D-myo-inositol 1,4,5-trisphosphate + H2O
myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
1D-myo-inositol 3,4,5-trisphosphate + H2O
1D-myo-inositol 3,4-bisphosphate + phosphate
Substrates: -
Products: -
Products: -
?
1D-myo-inositol 3,5-bisphosphate + H2O
1D-myo-inositol 3-phosphate + phosphate
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
inositol 4,5-bisphosphate + H2O
inositol 4-phosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O
phosphatidylinositol 4-phosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O
phosphatidylinositol 4-phosphate + phosphate
-
Substrates: regulation of the 1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate level at membrane ruffels
Products: -
Products: -
?
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
1D-myo-inositol 1,3,4-trisphosphate + phosphate
Substrates: -
Products: -
Products: -
?
1D-myo-inositol 1,4,5-trisphosphate + H2O
1D-myo-inositol 1,4-bisphosphate + phosphate
Substrates: specific for
Products: -
Products: -
?
1D-myo-inositol 1,4,5-trisphosphate + H2O
1D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: 1D-myo-inositol 1,4,5-trisphosphate metabolism, regulation, overview
Products: -
Products: -
?
1D-myo-inositol 1,4,5-trisphosphate + H2O
1D-myo-inositol 1,4-bisphosphate + phosphate
Substrates: specific for
Products: -
Products: -
?
1D-myo-inositol 1,4,5-trisphosphate + H2O
1D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: the enzyme is involved in Ins(1,4,5)P3-mediated Ca2+ signaling associated to PRIP-1, a Ins(1,4,5)P3-binding protein, overview
Products: -
Products: -
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1D-myo-inositol 1,4,5-trisphosphate + H2O
1D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: the enzyme is involved in the metabolism of polyphosphoinisotide in cellular signalling
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: product is precursor for inositol 1,3,4,5,6-pentiskphosphate via inositol 1,3,4,6-tetraiskphosphate
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: product is precursor for inositol 1,3,4,5,6-pentiskphosphate via inositol 1,3,4,6-tetraiskphosphate
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
Substrates: product is precursor for inositol 1,3,4,5,6-pentiskphosphate via inositol 1,3,4,6-tetraiskphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
Frog
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: involved in regulation of excitation-contraction coupling in skeletal muscle
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: involved in regulation of excitation-contraction coupling in skeletal muscle
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
D-myo-inositol 1,4,5-trisphosphate + H2O
D-myo-inositol 1,4-bisphosphate + phosphate
-
Substrates: regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
Products: -
Products: -
?
additional information
?
-
-
Substrates: enzyme knockout results in decrease in nucleocytoplasmic inositol phosphate 6-/3-kinases Ipk2/Ipk1-dependent inositol hexakisphosphate synthesis, overview
Products: -
Products: -
?