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Literature summary for 3.1.3.56 extracted from

  • Jefferson, A.B.; Majerus, P.W.
    Properties of type II inositol polyphosphate 5-phosphatase (1995), J. Biol. Chem., 270, 9370-9377.
    View publication on PubMed
Search for more literature for 3.1.3.56

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 insect cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C939S eliminates isoprenylation of enzyme which reduces activity towards phosphatidylinositol 4,5-bisphosphate Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O Homo sapiens
-
 phosphatidylinositol 4-phosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O Homo sapiens regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
inositol 4,5-bisphosphate + H2O Homo sapiens
-
 inositol 4-phosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification isoprenylation at Cys-939 Homo sapiens
side-chain modification isoprenylation Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O
-
 Homo sapiens phosphatidylinositol 4-phosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Homo sapiens D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Homo sapiens D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
inositol 4,5-bisphosphate + H2O
-
 Homo sapiens inositol 4-phosphate + phosphate
-
 ?