Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.56 extracted from

  • Mochizuki, Y.; Takenawa, T.
    Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles (1999), J. Biol. Chem., 274, 36790-36795.
    View publication on PubMed
Search for more literature for 3.1.3.56

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-7 cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
DELTA1-119 no significant influence on localization of enzyme Rattus norvegicus
DELTA1-311 no significant influence on localization of enzyme Rattus norvegicus
DELTA1-433 enzyme mainly in cytoplasm Rattus norvegicus
DELTA725-1001 enzyme exclusively cytoplasmic Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane ruffling membranes Rattus norvegicus 16020
-
membrane two isoforms postulated one of which is membrane associated Rattus norvegicus 16020
-
soluble two isoforms postulated one of which is soluble Rattus norvegicus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
107000
-
 calculated molecular mass, found to be slightly larger in SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O Rattus norvegicus regulation of the 1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate level at membrane ruffels phosphatidylinositol 4-phosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O Rattus norvegicus regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein cytoplasmic enzyme highly phosphorylated Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain PIPP enzyme Rattus norvegicus
-
heart PIPP enzyme Rattus norvegicus
-
kidney PIPP enzyme Rattus norvegicus
-
liver isoform of PIPP enzyme Rattus norvegicus
-
lung PIPP enzyme Rattus norvegicus
-
additional information PIPP enzyme not expressed in spleen, thymus, skeletal muscle, testis and skin Rattus norvegicus
-
small intestine PIPP enzyme Rattus norvegicus
-
stomach PIPP enzyme Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O
-
 Rattus norvegicus phosphatidylinositol 4-phosphate + phosphate
-
 ?
1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate + H2O regulation of the 1-(3-sn-phosphatidyl)-L-myo-inositol 4,5-bisphosphate level at membrane ruffels Rattus norvegicus phosphatidylinositol 4-phosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Rattus norvegicus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
D-myo-inositol 1,4,5-trisphosphate + H2O regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate Rattus norvegicus D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
proline-rich inositol polyphosphate 5-phosphatase PIPP Rattus norvegicus