EC Number |
General Information |
Reference |
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3.5.4.B9 | metabolism |
the APOBEC3 family has many roles, such as restricting endogenous and exogenous retrovirus replication and retrotransposon insertion events and reducing DNA-induced inflammation |
755694 |
3.5.4.B9 | metabolism |
the enzyme generates cytidine to deoxyuridine mutations in single-stranded DNA, and is capable of restricting replication of HIV-1 by generating mutations in viral genome |
757774 |
3.5.4.B9 | physiological function |
APOBEC3G is a single-stranded DNA cytidine deaminase capable of restricting retroviral replication |
723285 |
3.5.4.B9 | physiological function |
APOBEC3G protein inhibits HCV replication through direct binding at non-structural protein NS3 at its C-terminus, which is responsible for NS3's helicase and NTPase activities |
735015 |
3.5.4.B9 | physiological function |
the enzyme causes C to T mutations in the cDNA copy of the HIV-1 genome |
719342 |
3.5.4.B9 | physiological function |
the enzyme causes mutational diversity by initiating mutations on regions of single-stranded DNA. The enzyme enters the cytoplasm of the targeted T cell and catalyzes C deaminations on reverse transcribed cDNA causing HIV-1 retroviral inactivation. Enzyme-initiated mutations boost human fitness and restricts HIV-1 replication in the absence of the viral infectivity factor. The enzyme is involved in hepatic metastasis of colorectal cancer |
721999 |
3.5.4.B9 | physiological function |
the enzyme exhibits anti-human immunodeficiency virus-1 (HIV-1) activity by deaminating cytidines of the minus strand of HIV-1. Virus infectivity factor of HIV-1 counteracts the anti-HIV-1 activity of the enzyme |
722114 |
3.5.4.B9 | physiological function |
the enzyme inhibits HIV replication and inhibits retroviral infection by deaminating first strand cDNA, generating viral DNA mutations and potential viral elimination |
722103 |
3.5.4.B9 | physiological function |
the enzyme is a single-stranded DNA cytosine deaminase that functions in innate immunity against retroviruses and retrotransposons. The enzyme can potently restrict virus infectivity factor-deficient HIV-1 replication by catalyzing excessive levels of G->A hypermutation. Sublethal levels of enzyme-catalyzed mutation may contribute to the high level of HIV-1 fitness and its incurable prognosis |
722064 |
3.5.4.B9 | physiological function |
the enzyme is an endogenous inhibitor of human immunodeficiency virus type 1 (HIV-1) replication, able to induce G to A hypermutation in newly synthesized viral DNA |
723260 |