Literature summary for 3.5.4.B9 extracted from

Carpenter, M.A.; Rajagurubandara, E.; Wijesinghe, P.; Bhagwat, A.S.
Determinants of sequence-specificity within human AID and APOBEC3G (2010), DNA Repair, 9, 579-587.

Search for more literature for 3.5.4.B9

Cloned(Commentary)

Cloned (Comment)	Organism
the carboxyl-terminal catalytic domain is expressed in Escherichia coli BL-21 DE3 codon+RIL cells	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	the active site of the carboxy-terminal domain contains a Zn2+ ion	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
cytosine in single-stranded viral DNA + H2O	Homo sapiens	the enzyme strongly prefers cytosines in a run of C's usually targeting the last base in the run. The enzyme readily converts the third cytosine in CCC to uracil but does not convert the first or the second cytosine in the sequence at detectable levels	uracil in single-stranded viral DNA + NH3	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9HC16	-	-

Purification (Commentary)

Purification (Comment)	Organism
glutathione Sepharose column chromatography and MonoQ column chromatography	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cytosine in single-stranded viral DNA + H2O	the enzyme strongly prefers cytosines in a run of C's usually targeting the last base in the run. The enzyme readily converts the third cytosine in CCC to uracil but does not convert the first or the second cytosine in the sequence at detectable levels	Homo sapiens	uracil in single-stranded viral DNA + NH3	-	?

Synonyms

Synonyms	Comment	Organism
A3G	-	Homo sapiens
APOBEC3G	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	the enzyme causes C to T mutations in the cDNA copy of the HIV-1 genome	Homo sapiens

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Release 2023.1 (January 2023)