EC Number   |
General Information |
Reference |
|---|
   3.5.4.B9 | physiological function |
the enzyme is an important component of the cellular innate immune response to retroviral infection. The enzyme APOBEC3G can extinguish HIV-1 infectivity by its incorporation into virus particles and subsequent cytosine deaminase activity that attacks the nascent viral cDNA during reverse transcription, causing lethal mutagenesis. The enzyme can also induce sublethal mutagenesis, which maintains virus infectivity and contribute to HIV-1 variation |
723071 |
| 3.5.4.B9 | physiological function |
the enzyme is capable of blocking retrovirus replication by editing viral cDNA and impairing reverse transcription |
721668 |
| 3.5.4.B9 | physiological function |
the enzyme is encapsulated by the HIV virion and facilitates restriction of HIV-1 infection in T cells by deaminating cytosines in nascent minus-strand complementary DNA |
723256 |
| 3.5.4.B9 | physiological function |
the enzyme mutates the human immunodeficiency virus (HIV) genome by converting deoxycytidine to deoxyuridine in signature trinucleotides (CCC, TCC) on minus strand viral DNA during reverse transcription. The enzyme restricts viral propagation by degrading or incapacitating the coding ability of the HIV genome. The enzyme contributes to the evasion of adaptive immunity by HIV |
723754 |
| 3.5.4.B9 | physiological function |
the enzyme restricts replication of HIV-1 by inducing viral genome mutagenesis through deamination of cytosine to uracil on HIV-1 cDNA processively through jumping and sliding. The jumping and sliding of Apo3G is needed for efficient mutational inactivation of HIV-1 |
722698 |
| 3.5.4.B9 | physiological function |
the single-stranded DNA-dependent cytosine deaminase inactivates HIV-1 in T cells by C to T hypermutation |
720014 |
