Cloned (Comment) | Organism |
---|---|
glutathione S-transferase-tagged enzyme is expressed in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C288A/C291A | the mutant enzyme shows about 18% activity compared to the wild type enzyme | Homo sapiens |
C97A/C100A | the mutant enzyme shows about 18% activity compared to the wild type enzyme | Homo sapiens |
H257A | the mutant enzyme shows about 10% activity compared to the wild type enzyme | Homo sapiens |
H81A | the mutant enzyme shows about 25% activity compared to the wild type enzyme | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | contains two zinc finger domains | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine in single-stranded viral DNA + H2O | Homo sapiens | - |
uracil in single-stranded viral DNA + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine in single-stranded viral DNA + H2O | - |
Homo sapiens | uracil in single-stranded viral DNA + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
APOBEC3G | - |
Homo sapiens |
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | - |
Homo sapiens |
CEM15 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is an endogenous inhibitor of human immunodeficiency virus type 1 (HIV-1) replication, able to induce G to A hypermutation in newly synthesized viral DNA | Homo sapiens |