Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine in single-stranded viral DNA + H2O | Homo sapiens | cytosine deamination occurs preferentially in CpC (5'GpG/CpC5') | uracil in single-stranded viral DNA + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9HC16 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine in single-stranded viral DNA + H2O | cytosine deamination occurs preferentially in CpC (5'GpG/CpC5') | Homo sapiens | uracil in single-stranded viral DNA + NH3 | - |
? | |
additional information | the enzyme alone extensively deaminates cDNA independently of reverse transcriptase. The cDNA has to be free of its RNA template to allow deamination. Deoxycytosine or dCTP are poor substrates | Homo sapiens | ? | - |
? | |
TTTCCCCGC + H2O | sequence with highest deamination rate | Homo sapiens | TTTCCUCGC + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
APOBEC3G | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | APOBEC3G is a single-stranded DNA cytidine deaminase capable of restricting retroviral replication | Homo sapiens |