EC Number   |
General Information |
Reference |
|---|
    1.14.19.30 | malfunction |
the lower dienoic acid content of the fadA mutant results in a tolerance of elevated temperatures during development, but not during the growth phase |
-, 734639 |
| 1.14.19.30 | metabolism |
delta 5 desaturase plays a role in the eicosapentaenoic acid biosynthetic pathway |
734019 |
| 1.14.19.30 | metabolism |
the C-peptide (a protein cleaved from pro-insulin) may function in regulating DELTA-5 desaturase enzyme activity. Relationship between body mass index, C-peptide, and DELTA-5-desaturase enzyme activity estimates in adult males |
746199 |
| 1.14.19.30 | metabolism |
the DELTA5-desaturase is involved in the last step of arachidonic acid (20:4n-6) biosynthesis from dihomo-gamma-linolenic acid (20:3n-6), contributing to the balance between the prostanoids of the 1- and 2-series |
734430 |
| 1.14.19.30 | physiological function |
Fads1 is an effector of LXR agonist-driven transcriptional control of fatty acid and cholesterol metabolic programs in the liver. Fads1 reciprocally regulates hepatic inflammation and lipogenesis. Fads1 knockdown promotes Dyslipidemia and Atherosclerosis in a diet-specific manner |
744187 |
| 1.14.19.30 | physiological function |
investigation of the effects of DELTA-5 and DELTA-6 desaturase on antibacterial and immunomodulatory activity in transgenic zebrafish infected with Vibrio alginolyticus. Overexpression of DELTA-5 and DELTA-6 desaturase enhances antibacterial activity at 4 and 12 h after injection of bacteria into muscle, as compared to controls. Expression of immune-related genes (IL-1b, IL-22, and TNF-a) is observed to be altered in transgenic fish after 4 h of bacterial infection, resulting in a significant decrease in the inflammatory response, as compared to control fish. Muscle-specific expression of transgenic desaturases in zebrafish not only enhances polyunsaturated fatty acid production, but also enhances antibacterial and anti-inflammatory activity |
744947 |
| 1.14.19.30 | physiological function |
involved in moth pheromone biosynthesis |
745441 |
| 1.14.19.30 | physiological function |
isoforms FadA and FadB are involved in temperature adaptation. Isoform FadA is mainly responsible for the production of dienoic fatty acids, whereas isoform FadB has a supplementary function |
-, 734639 |
