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Literature summary for 1.14.19.30 extracted from

  • Gromovsky, A.D.; Schugar, R.C.; Brown, A.L.; Helsley, R.N.; Burrows, A.C.; Ferguson, D.; Zhang, R.; Sansbury, B.E.; Lee, R.G.; Morton, R.E.; Allende, D.S.; Parks, J.S.; Spite, M.; Brown, J.M.
    DELTA-5 fatty acid desaturase FADS1 impacts metabolic disease by balancing proinflammatory and proresolving lipid mediators (2017), Arterioscler. Thromb. Vasc. Biol., 38, 218-231 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.19.30

Organism

Organism UniProt Comment Textmining
Homo sapiens O60427
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
-
 Homo sapiens arachidonic acid + ferricytochrome b5 + H2O
-
 ?

Synonyms

Synonyms Comment Organism
FADS1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function Fads1 is an effector of LXR agonist-driven transcriptional control of fatty acid and cholesterol metabolic programs in the liver. Fads1 reciprocally regulates hepatic inflammation and lipogenesis. Fads1 knockdown promotes Dyslipidemia and Atherosclerosis in a diet-specific manner Homo sapiens