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Information on EC 1.14.19.30 - acyl-lipid (8-3)-desaturase
for references in articles please use BRENDA:EC1.14.19.30
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EC Tree 1 Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
1.14.19.30 acyl-lipid (8-3)-desaturase
IUBMB Comments
The enzyme, which has been characterized from multiple organisms including the moss Physcomitrella patens, the marine microalga Rebecca salina, and the filamentous fungus Mortierella alpina, introduces a cis double bond at the 5-position in 20-carbon polyunsaturated fatty acids incorporated in a glycerolipid that contain a Δ8 double bond. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome.
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
- 1.14.19.30
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arachidonic
-
polyunsaturated
-
linoleic
-
desaturation
- phospholipid
-
desaturases
-
pufas
-
delta-6
-
docosahexaenoic
-
eicosapentaenoic
-
dihomo-gamma-linolenic
- delta6-desaturase
- elongase
-
monounsaturated
-
alpha-linolenic
-
gamma-linolenic
- stearoyl-coa
-
mortierella
-
omega-6
- alpina
-
8-hydroxyoctanoic
-
lc-pufas
- sesamin
-
eicosatrienoic
- medicine
- agriculture
- diagnostics
Reaction Schemes
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Synonyms
delta 5 desaturase, delta5-desaturase, delta-5 desaturase, delta-5-desaturase, fads2b, delta5 fatty acid desaturase, delta5-des, delta5-fatty acid desaturase, fat-4, desat7, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
acyl-lipid 5-desaturase
D5D
D5des
delta 5 desaturase
delta-5 desaturase
DELTA5 desaturase
DELTA5 fatty acid desaturase
DELTA5-Des
DELTA5-desaturase
DELTA5-fatty acid desaturase
DELTA5-fatty-acid desaturase
DES5
desat7
FadA
FadB
FADS1
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O
(1)
-
-
-
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
an (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O
(2)
-
-
-
an (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
(1)
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
(1)
-
-
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
-
-
-
an (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
(2)
an (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
(2)
-
-
an (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
MetaCyc
arachidonate biosynthesis I (6-desaturase, lower eukaryotes), arachidonate biosynthesis IV (8-detaturase, lower eukaryotes), icosapentaenoate biosynthesis I (lower eukaryotes), icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)
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SYSTEMATIC NAME
IUBMB Comments
DELTA8 acyl-lipid,ferrocytochrome b5:oxygen oxidoreductase (5,6 cis-dehydrogenating)
The enzyme, which has been characterized from multiple organisms including the moss Physcomitrella patens, the marine microalga Rebecca salina, and the filamentous fungus Mortierella alpina, introduces a cis double bond at the 5-position in 20-carbon polyunsaturated fatty acids incorporated in a glycerolipid that contain a Delta8 double bond. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(7Z)-octadec-7-enoic acid + ferrocytochrome b5 + O2 + H+
(5Z,7Z)-octadeca-5,7-dienoic acid + ferricytochrome b5 + H2O
-
Substrates: 5% conversion
Products: -
Products: -
?
(8Z,11Z,14Z)-eicosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-eicosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
(8Z,11Z,14Z,17Z)-eicosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-eicosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
Substrates: best substrate
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
an (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
di-homo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
-
Substrates: 55% conversion
Products: -
Products: -
?
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
eicosa-11,14,17-trienoate + acceptor + O2 + H+
eicosa-5,11,14,17-tetraenoate + ?
Substrates: -
Products: i.e. juniperoate
Products: i.e. juniperoate
?
eicosa-11,14,17-trienoic acid + acceptor + O2 + H+
eicosa-5,11,14,17-tetraenoic acid + ?
-
Substrates: -
Products: i.e. juniperoic acid
Products: i.e. juniperoic acid
?
eicosa-11,14,17-trienoyl-CoA + acceptor + O2 + H+
eicosa-5,11,14,17-tetraenoyl-CoA + ?
-
Substrates: -
Products: i.e. juniperoyl-CoA
Products: i.e. juniperoyl-CoA
?
eicosa-11,14-dienoate + acceptor + O2 + H+
eicosa-5,11,14-trienoate + ?
Substrates: -
Products: i.e. sciadonoate
Products: i.e. sciadonoate
?
eicosa-11,14-dienoic acid + acceptor + O2 + H+
eicosa-5,11,14-trienoic acid + ?
-
Substrates: -
Products: i.e. sciadonoic acid
Products: i.e. sciadonoic acid
?
eicosa-11,14-dienoyl-CoA + acceptor + O2 + H+
eicosa-5,11,14-trienoyl-CoA + ?
-
Substrates: -
Products: i.e. sciadonoyl-CoA
Products: i.e. sciadonoyl-CoA
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
Substrates: -
Products: -
Products: -
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
Substrates: (8Z,11Z,14Z)-icosa-8,11,14-trienoate i.e. di-homo-gamma-linolenate. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome
Products: (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoate i.e. arachidonate
Products: (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoate i.e. arachidonate
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
Substrates: -
Products: -
Products: -
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
Substrates: (8Z,11Z,14Z)-icosa-8,11,14-trienoate i.e. di-homo-gamma-linolenate. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome
Products: (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoate i.e. arachidonate
Products: (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoate i.e. arachidonate
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
Substrates: (8Z,11Z,14Z)-icosa-8,11,14-trienoate i.e. di-homo-gamma-linolenate. Expression of the enzyme in Saccharomyces cerevisiae results in the production of the DELTA5-containing fatty acid arachidonic acid in cells that are provided di-homo-gamma-linolenic acid
Products: (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoate i.e. arachidonate
Products: (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoate i.e. arachidonate
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
Substrates: -
Products: -
Products: -
?
an (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
Substrates: -
Products: -
Products: -
?
an (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
Substrates: -
Products: -
Products: -
?
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
Substrates: -
Products: -
Products: -
?
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
Substrates: -
Products: -
Products: -
?
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
linoleic acid + ferrocytochrome b5 + O2 + H+
pinolenic acid + ferricytochrome b5 + H2O
-
Substrates: -
Products: pinoleinic acid is DELTA5,9,12-18:3
Products: pinoleinic acid is DELTA5,9,12-18:3
?
linoleic acid + ferrocytochrome b5 + O2 + H+
pinolenic acid + ferricytochrome b5 + H2O
-
Substrates: -
Products: pinoleinic acid is DELTA5,9,12-18:3
Products: pinoleinic acid is DELTA5,9,12-18:3
?
oleic acid + ferrocytochrome b5 + O2 + H+
taxoleic acid + ferricytochrome b5 + H2O
-
Substrates: -
Products: taxoleic acid is DELTA5,9-18:2
Products: taxoleic acid is DELTA5,9-18:2
?
oleic acid + ferrocytochrome b5 + O2 + H+
taxoleic acid + ferricytochrome b5 + H2O
-
Substrates: -
Products: taxoleic acid is DELTA5,9-18:2
Products: taxoleic acid is DELTA5,9-18:2
?
additional information
?
-
-
Substrates: the enzyme catalyzes the introduction of a cis-double bond at the DELTA5 position of a wide range of saturated fatty acids including tetradecanoic acid, pentadecanoic acid, octadecanoic acid, 14-methyl pentadecanoic acid, 15-methylhexadecanoic acid, and 14-methylhexadecanoic acid
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme catalyzes the introduction of a cis-double bond at the DELTA5 position of a wide range of saturated fatty acids including tetradecanoic acid, pentadecanoic acid, octadecanoic acid, 14-methyl pentadecanoic acid, 15-methylhexadecanoic acid, and 14-methylhexadecanoic acid
Products: -
Products: -
?
additional information
?
-
-
Substrates: no activity with 20:1DELTA11, 18:2DELTA9,12, and 18:3DELTA9,12,15
Products: -
Products: -
?
additional information
?
-
Substrates: the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8-C16)
Products: -
Products: -
?
additional information
?
-
-
Substrates: the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8-C16)
Products: -
Products: -
?
additional information
?
-
Substrates: the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8-C16)
Products: -
Products: -
?
additional information
?
-
Substrates: the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8-C16)
Products: -
Products: -
?
additional information
?
-
-
Substrates: the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8-C16)
Products: -
Products: -
?
additional information
?
-
Substrates: the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8ĀC16)
Products: -
Products: -
?
additional information
?
-
Substrates: the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8ĀC16)
Products: -
Products: -
?
additional information
?
-
-
Substrates: the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8ĀC16)
Products: -
Products: -
?
additional information
?
-
Substrates: no activity with 18:3(n-3)
Products: -
Products: -
?
additional information
?
-
-
Substrates: no activity with 18:3(n-3)
Products: -
Products: -
?
additional information
?
-
Substrates: the enzyme can desaturate C20:4(n-3) and C20:3(n-6) to C20:5(n-3) and C20:4(n-6) respectively, displaying a DELTA5 desaturation activity
Products: -
Products: -
?
additional information
?
-
Substrates: no activity with 18:2(DELTA9,12), 18:3n-3(DELTA9,12,15), or 22:5n-3(DELTA7,11,13,16,19)
Products: -
Products: -
?
additional information
?
-
Substrates: expression of the fasd2b in yeast generates a protein that converts eicosatetraenoic acid (20:4n-3) to eicosapentaenoic acid (20:5n-3), and functions as a monofunctional DELTA5 desaturase. The enzyme does not show any DELTA8 desaturase activity
Products: -
Products: -
?
additional information
?
-
-
Substrates: expression of the fasd2b in yeast generates a protein that converts eicosatetraenoic acid (20:4n-3) to eicosapentaenoic acid (20:5n-3), and functions as a monofunctional DELTA5 desaturase. The enzyme does not show any DELTA8 desaturase activity
Products: -
Products: -
?
additional information
?
-
-
Substrates: no products are detected with the C18 fatty acid linoleic and gamma-linolenic acids or with the C22 fatty acid adrenic and docosapentaenoic acids
Products: -
Products: -
?
additional information
?
-
-
Substrates: no activity with 18:3(n-3)
Products: -
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(8Z,11Z,14Z)-eicosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-eicosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
(8Z,11Z,14Z,17Z)-eicosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-eicosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
Substrates: best substrate
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
Substrates: -
Products: -
Products: -
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
Substrates: -
Products: -
Products: -
?
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
Substrates: -
Products: -
Products: -
?
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
-
Substrates: -
Products: -
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
the enzyme does not contain a cytochrome b5 domain
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2-(2,2,3,3,3-pentafluoropropoxy)-3-[4-(2,2,2-trifluoroethoxy)phenyl]-5,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-4,6-dione
-
-
5-[(4S,5S)-5-(4-fluorophenyl)-4-methyl-2-oxo-1,3-oxazolidin-3-yl]benzene-1,3-dicarbonitrile
CP-24879
the combined DELTA5 desaturase/DELTA6 desaturase inhibitor significantly reduces intracellular lipid accumulation and inflammatory injury in hepatocytes
3-[(4S,5S)-5-(4-fluorophenyl)-4-methyl-2-oxo-1,3-oxazolidin-3-yl]benzonitrile
derivative with improved metabolic stability
3-[(4S,5S)-5-(4-fluorophenyl)-4-methyl-2-oxo-1,3-oxazolidin-3-yl]benzonitrile
derivative with improved metabolic stability
3-[(4S,5S)-5-(4-fluorophenyl)-4-methyl-2-oxo-1,3-oxazolidin-3-yl]benzonitrile
-
derivative with improved metabolic stability
5-[(4S,5S)-5-(4-fluorophenyl)-4-methyl-2-oxo-1,3-oxazolidin-3-yl]benzene-1,3-dicarbonitrile
-
5-[(4S,5S)-5-(4-fluorophenyl)-4-methyl-2-oxo-1,3-oxazolidin-3-yl]benzene-1,3-dicarbonitrile
inhibitor endowed with excellent DELTA5 desaturase binding affinity, cellular activity, and high oral bioavailability in a mouse. It exhibits robust in vivo hepatic arachidonic acid/dihomo-gamma-linolenic acid ratio reduction (a target engagement marker) in an atherosclerosis mouse model
5-[(4S,5S)-5-(4-fluorophenyl)-4-methyl-2-oxo-1,3-oxazolidin-3-yl]benzene-1,3-dicarbonitrile
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid]
-
the DELTA5 desaturase activity in kidney microsomes increases linearly with the substrate concentration up to 0.02 mM