Literature summary for 1.14.19.30 extracted from

Wang, Y.D.; Peng, K.C.; Wu, J.L.; Chen, J.Y.
Transgenic expression of salmon DELTA-5 and DELTA-6 desaturase in zebrafish muscle inhibits the growth of Vibrio alginolyticus and affects fish immunomodulatory activity (2014), Fish Shellfish Immunol., 39, 223-230 .

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Application

Application	Comment	Organism
agriculture	DELTA-5 and DELTA-6 desaturase are candidate genes for use in aquaculture, to enhance both disease resistance and fish oil production	Salmo salar

Cloned(Commentary)

Cloned (Comment)	Organism
investigation of the effects of DELTA-5 and DELTA-6 desaturase on antibacterial and immunomodulatory activity in transgenic zebrafish infected with Vibrio alginolyticus. Overexpression of DELTA-5 and DELTA-6 desaturase enhances antibacterial activity at 4 and 12 h after injection of bacteria into muscle, as compared to controls. Expression of immune-related genes (IL-1b, IL-22, and TNF-a) is observed to be altered in transgenic fish after 4 h of bacterial infection, resulting in a significant decrease in the inflammatory response, as compared to control fish. Muscle-specific expression of transgenic desaturases in zebrafish not only enhances polyunsaturated fatty acid production, but also enhances antibacterial and anti-inflammatory activity	Salmo salar

Cloned (Comment)

Organism

investigation of the effects of DELTA-5 and DELTA-6 desaturase on antibacterial and immunomodulatory activity in transgenic zebrafish infected with Vibrio alginolyticus. Overexpression of DELTA-5 and DELTA-6 desaturase enhances antibacterial activity at 4 and 12 h after injection of bacteria into muscle, as compared to controls. Expression of immune-related genes (IL-1b, IL-22, and TNF-a) is observed to be altered in transgenic fish after 4 h of bacterial infection, resulting in a significant decrease in the inflammatory response, as compared to control fish. Muscle-specific expression of transgenic desaturases in zebrafish not only enhances polyunsaturated fatty acid production, but also enhances antibacterial and anti-inflammatory activity

Salmo salar

Organism

Organism	UniProt	Comment	Textmining
Salmo salar	Q8QGE2	-	-

Synonyms

Synonyms	Comment	Organism
delta-5 desaturase	-	Salmo salar

General Information

General Information	Comment	Organism
physiological function	investigation of the effects of DELTA-5 and DELTA-6 desaturase on antibacterial and immunomodulatory activity in transgenic zebrafish infected with Vibrio alginolyticus. Overexpression of DELTA-5 and DELTA-6 desaturase enhances antibacterial activity at 4 and 12 h after injection of bacteria into muscle, as compared to controls. Expression of immune-related genes (IL-1b, IL-22, and TNF-a) is observed to be altered in transgenic fish after 4 h of bacterial infection, resulting in a significant decrease in the inflammatory response, as compared to control fish. Muscle-specific expression of transgenic desaturases in zebrafish not only enhances polyunsaturated fatty acid production, but also enhances antibacterial and anti-inflammatory activity	Salmo salar