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Literature summary for 1.14.19.30 extracted from

  • Rodriguez, A.; Sarda, P.; Nessmann, C.; Boulot, P.; Leger, C.; Descomps, B.
    DELTA6- and DELTA5-desaturase activities in the human fetal liver: Kinetic aspects (1998), J. Lipid Res., 39, 1825-1832.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0245
-
 dihomo-gamma-linolenic acid at pH 7.4 and 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ Homo sapiens
-
 (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver fetal liver Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
-
 Homo sapiens (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
 ?
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
-
 Homo sapiens arachidonic acid + ferricytochrome b5 + H2O
-
 ?

Synonyms

Synonyms Comment Organism
DELTA5-desaturase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
cytochrome b5
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the DELTA5-desaturase is involved in the last step of arachidonic acid (20:4n-6) biosynthesis from dihomo-gamma-linolenic acid (20:3n-6), contributing to the balance between the prostanoids of the 1- and 2-series Homo sapiens