EC Number   |
General Information |
Reference |
|---|
    2.3.3.8 | malfunction |
deletion of the enzyme results in a complete loss of self and female fertility as well as a reduction in asexual reproduction, virulence, and trichothecene production. Although lipid synthesis is not affected by enzyme deletion, histone acetylation is dramatically reduced in the enzyme deletion mutants during sexual development |
-, 719545 |
| 2.3.3.8 | metabolism |
DNA methyltransferase 1 is regulated by ATP-citrate lyase |
736797 |
| 2.3.3.8 | malfunction |
enzyme activity inhibition as well as gene silencing lead to reduced nitric oxide, reactive oxygen species and prostaglandin E2 inflammatory mediators |
735597 |
| 2.3.3.8 | metabolism |
enzyme in the de novo lipogenesis pathway. The enzyme is required for low molecular weight cyclin E-mediated transformation, migration, and invasion of breast cancer cells in vitro along with tumor growth in vivo |
756335 |
| 2.3.3.8 | malfunction |
enzyme inactivation decreases fatty acid synthesis by 60 to 80% |
735713 |
| 2.3.3.8 | malfunction |
enzyme knockdown triggers cellular senescence and activation of tumor suppressor p53 |
736093 |
| 2.3.3.8 | physiological function |
enzyme overexpression in Arabidopsis is associated with a 30% increase in wax on stems, while overexpression of a chimeric homomeric enzyme in the laticifer of roots of dandelion leads to a 4 and 2fold increase in rubber and triterpene content, respectively |
736996 |
| 2.3.3.8 | metabolism |
essential enzyme for generating acetyl-CoA, a key metabolite for the first step in fatty acid synthesis and for histone acetylation. Regulation of the enzyme activity is a potentially important point of control for cell cycle regulation in the myeloid lineage |
756281 |
| 2.3.3.8 | malfunction |
inhibition of the enzyme suppresses in vitro glioblastoma cell migration, clonogenicity and brain invasion under glycolytic conditions and enhances the suppressive effects of a Met inhibitor on cell migration |
704077 |
| 2.3.3.8 | metabolism |
involved in lung cancer pathogenesis |
703014 |
