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Literature summary for 2.3.3.8 extracted from

  • Lucenay, K.S.; Doostan, I.; Karakas, C.; Bui, T.; Ding, Z.; Mills, G.B.; Hunt, K.K.; Keyomarsi, K.
    Cyclin E associates with the lipogenic enzyme ATP-citrate lyase to enable malignant growth of breast cancer cells (2016), Cancer Res., 76, 2406-2418 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.3.8

Organism

Organism UniProt Comment Textmining
Homo sapiens P53396
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-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
ACLY
-
 Homo sapiens
ATP-citrate lyase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens low molecular weight cyclin E upregulates enzymatic activity, subsequently increasing lipid droplet formation, thereby providing cells with essential building blocks to support growth up

General Information

General Information Comment Organism
metabolism enzyme in the de novo lipogenesis pathway. The enzyme is required for low molecular weight cyclin E-mediated transformation, migration, and invasion of breast cancer cells in vitro along with tumor growth in vivo Homo sapiens