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Literature summary for 2.3.3.8 extracted from

  • Infantino, V.; Iacobazzi, V.; Palmieri, F.; Menga, A.
    ATP-citrate lyase is essential for macrophage inflammatory response (2013), Biochem. Biophys. Res. Commun., 440, 105-111.
    View publication on PubMed
Search for more literature for 2.3.3.8

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + phosphate + acetyl-CoA + oxaloacetate Homo sapiens
-
 ATP + citrate + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Homo sapiens
-
U-937 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphate + acetyl-CoA + oxaloacetate
-
 Homo sapiens ATP + citrate + CoA
-
 ?

Synonyms

Synonyms Comment Organism
ACLY
-
 Homo sapiens
ATP-citrate lyase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme mRNA and protein levels markedly (about 2.5fold) and quickly increase in activated macrophages. Tumour necrosis factor alpha and interferon gamma upregulate enzyme gene expression up

General Information

General Information Comment Organism
malfunction enzyme activity inhibition as well as gene silencing lead to reduced nitric oxide, reactive oxygen species and prostaglandin E2 inflammatory mediators Homo sapiens
physiological function the enzyme is essential for macrophage inflammatory response Homo sapiens