EC Number   |
General Information |
Reference  |
|---|
    2.3.3.8 | malfunction |
ATP citrate lyase knockdown induces proliferation arrest, cell-cycle arrest, and apoptosis in cancer cells and results in elevated expression of acyl-CoA synthetase short-chain family member 2 |
720439 |
| 2.3.3.8 | malfunction |
enzyme activity inhibition as well as gene silencing lead to reduced nitric oxide, reactive oxygen species and prostaglandin E2 inflammatory mediators |
735597 |
| 2.3.3.8 | physiological function |
the enzyme is essential for macrophage inflammatory response |
735597 |
| 2.3.3.8 | malfunction |
enzyme inactivation decreases fatty acid synthesis by 60 to 80% |
735713 |
| 2.3.3.8 | metabolism |
the enzyme plays an essential role in fatty acid synthesis |
735713 |
| 2.3.3.8 | physiological function |
the enzyme regulates mitochondrial function and cardiolipin synthesis and content in skeletal muscle |
735902 |
| 2.3.3.8 | malfunction |
enzyme knockdown triggers cellular senescence and activation of tumor suppressor p53 |
736093 |
| 2.3.3.8 | physiological function |
the enzyme regulates cellular senescence via an AMPK- and p53-dependent pathway |
736093 |
| 2.3.3.8 | physiological function |
isoforms Acl1 and Acl2 coordinately modulate the cytoplasmic acetyl-CoA levels to regulate growth, development, and citric acid synthesis in Aspergillus niger |
-, 736591 |
| 2.3.3.8 | metabolism |
DNA methyltransferase 1 is regulated by ATP-citrate lyase |
736797 |
