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Literature summary for 2.3.3.8 extracted from

  • Das, S.; Morvan, F.; Jourde, B.; Meier, V.; Kahle, P.; Brebbia, P.; Toussaint, G.; Glass, D.J.; Fornaro, M.
    ATP citrate lyase improves mitochondrial function in skeletal muscle (2015), Cell Metab., 21, 868-876.
    View publication on PubMed
Search for more literature for 2.3.3.8

Activating Compound

Activating Compound Comment Organism Structure
insulin growth factor 1 induces enzyme activation in an AKT-dependent fashion Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + phosphate + acetyl-CoA + oxaloacetate Mus musculus
-
 ATP + citrate + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphate + acetyl-CoA + oxaloacetate
-
 Mus musculus ATP + citrate + CoA
-
 ?

Synonyms

Synonyms Comment Organism
ACL
-
 Mus musculus
ATP citrate lyase
-
 Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme regulates mitochondrial function and cardiolipin synthesis and content in skeletal muscle Mus musculus