Literature summary for 2.3.3.8 extracted from

Beckner, M.E.; Fellows-Mayle, W.; Zhang, Z.; Agostino, N.R.; Kant, J.A.; Day, B.W.; Pollack, I.F.
Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas (2009), Int. J. Cancer, 126, 2282-2295.

Search for more literature for 2.3.3.8

Inhibitors

Inhibitors	Comment	Organism	Structure
Hydroxycitrate	-	Homo sapiens
radiciol	-	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
120608	-	x * 120608, calculated, identified by mass spectrometry	Homo sapiens
125000	-	x * 125000, SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Homo sapiens	P53396	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
glioblastoma cell	-	Homo sapiens	-
LN-229 cell	-	Homo sapiens	-
U-87MG cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + citrate + CoA	-	Homo sapiens	ADP + phosphate + acetyl-CoA + oxaloacetate	-	?

Subunits

Subunits	Comment	Organism
?	x * 125000, SDS-PAGE	Homo sapiens
?	x * 120608, calculated, identified by mass spectrometry	Homo sapiens

Synonyms

Synonyms	Comment	Organism
ACLY	-	Homo sapiens
ATP citrate lyase isoform 2	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	there are about 3fold increased levels of the enzyme in glioblastoma pseudopodia compared to unmigrated cells	up

General Information

General Information	Comment	Organism
malfunction	inhibition of the enzyme suppresses in vitro glioblastoma cell migration, clonogenicity and brain invasion under glycolytic conditions and enhances the suppressive effects of a Met inhibitor on cell migration	Homo sapiens
physiological function	ATP citrate lyase is a positive regulator of glycolytic function in glioblastomas	Homo sapiens

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Release 2023.1 (January 2023)