EC Number |
Inhibitors |
Structure |
---|
2.8.1.6 | 5'-deoxyadenosine |
strong inhibitor, reversible, 90% inhibition upon addition of 1 equivalent of 5'-deoxyadenosine with regard to the enzyme |
|
2.8.1.6 | 5'-deoxyadenosine |
product inhibition. The combination of both products in equimolar concentrations results in more than simple additive inhibition, suggesting that they bind cooperatively to the enzyme. |
|
2.8.1.6 | 5'-deoxyadenosine |
competitive, inhibits the growth of Mycobacterium tuberculosis H37Ra with an MIC of 392.6 microg/ml |
|
2.8.1.6 | acidomycin |
structural analog of biotin, complete inhibition at 0.4 mM, 50% inhibition at 0.035 mM |
|
2.8.1.6 | acidomycin |
acidomycin inhibits biotin synthesis through the competitive inhibition of biotin synthase BioB and also stimulates unproductive cleavage of S-adenosyl-L-methionine to generate the toxic metabolite 5'-deoxyadenosine. Acidomycin selectively accumulates in Mycobycterium tuberculosis. The development of spontaneous resistance by Mycobacterium tuberculosis to acidomycin is difficult, and only low-level resistance to acidomycin is observed by overexpression of BioB |
|
2.8.1.6 | Cd2+ |
1 mM, almost complete inhibition |
|
2.8.1.6 | Co2+ |
1 mM, almost complete inhibition |
|
2.8.1.6 | Cu2+ |
1 mM, almost complete inhibition |
|
2.8.1.6 | Fe2+ |
above 1 mM |
|
2.8.1.6 | Hg2+ |
1 mM, almost complete inhibition |
|