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Ligand Fe2+
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Basic Ligand Information
BRENDA
KEGG
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Show all BRENDA pathways known for Fe2+
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open all tablesRoles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (67 results)
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EC NUMBER 
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
protoheme + reduced acceptor + O2 + Fe2+ = biliverdin-IX-alpha + CO + Fe3+ + acceptor + H2O
-
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe2+ + H+ + O2 = Fe3+ + H2O
437995, 437996, 437997, 437998, 437999, 438000, 438001, 438002, 438003, 438004, 438005, 438006, 438007, 438008, 438009, 438010, 438011, 438012, 438013, 438014, 438015, 438016, 438017, 438020, 438021, 438022, 438024, 438026, 438027, 438028, 438029, 438030, 438025, 438032, 438023, 438019, 438018, 438031, 438033
Fe(II) + O2 + H2O = [FeO(OH)] + H+
protoporphyrin + Fe2+ = protoheme + H+
protoporphyrin IX + Fe2+ = ?
In Vivo Product in Enzyme-catalyzed Reactions (26 results)
EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
protoheme + [reduced NADPH-hemoprotein reductase] + H+ + O2 = biliverdin-IX-alpha + CO + Fe2+ + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
protoheme + [reduced NADPH-hemoprotein reductase] + O2 = biliverdin + Fe2+ + CO + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
hemin + reduced ferredoxin [iron-sulfur] cluster + O2 + H+ = biliverdin IXalpha + Fe2+ + CO + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
mesoheme + reduced ferredoxin [iron-sulfur] cluster + O2 + H+ = mesobiliverdin IXalpha + Fe2+ + CO + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
protoheme + 6 reduced ferredoxin [iron-sulfur] cluster + 3 O2 + 6 H+ = biliverdin + Fe2+ + CO + 6 oxidized ferredoxin [iron-sulfur] cluster + 3 H2O
-
-
protoheme + reduced ferredoxin [iron-sulfur] cluster + O2 + H+ = biliverdin + Fe2+ + CO + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
protoheme + reduced ferredoxin [iron-sulfur] cluster + O2 + H+ = biliverdin IXalpha + Fe2+ + CO + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
2 S-adenosyl-L-methionine + protoheme + 2 reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + anaerobilin + Fe2+ + 2 oxidized flavodoxin
-
-
Substrate in Enzyme-catalyzed Reactions (2738 results)
EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
protoheme + reduced acceptor + O2 + Fe2+ = biliverdin-IX-alpha + CO + Fe3+ + acceptor + H2O
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