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Ligand 5'-deoxyadenosine

Basic Ligand Information

Molecular Structure

Related pathways

Pathway Source

Pathways

BRENDA

1,4-dihydroxy-6-naphthoate biosynthesis, biotin biosynthesis, factor 420 biosynthesis, heme metabolism, lipoate biosynthesis, macrolide antibiotic biosynthesis, vitamin B1 metabolism more

MetaCyc

(aminomethyl)phosphonate degradation, 1,4-dihydroxy-6-naphthoate biosynthesis I, 1,4-dihydroxy-6-naphthoate biosynthesis II, 3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic), 3PG-factor 420 biosynthesis, 4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis I, 5'-deoxyadenosine degradation I, 5'-deoxyadenosine degradation II, 5,6-dimethylbenzimidazole biosynthesis II (anaerobic), 5-hydroxybenzimidazole biosynthesis (anaerobic), 5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic), 5-methoxybenzimidazole biosynthesis (anaerobic), 7,8-dimethylmenaquinone biosynthesis, 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis, 8-methylmenaquinone biosynthesis, bacteriochlorophyll e biosynthesis, biotin biosynthesis from 8-amino-7-oxononanoate I, biotin biosynthesis from 8-amino-7-oxononanoate II, biotin biosynthesis from 8-amino-7-oxononanoate III, clorobiocin biosynthesis, dTDP-D-desosamine biosynthesis, factor 420 biosynthesis I (archaea), factor 420 biosynthesis II (mycobacteria), FeMo cofactor biosynthesis, fosfomycin biosynthesis, glyphosate degradation III, heme b biosynthesis II (oxygen-independent), heme b biosynthesis III (from siroheme), heme d1 biosynthesis, heme degradation V, hopanoid biosynthesis (bacteria), linezolid resistance, lipoate biosynthesis and incorporation I, lipoate biosynthesis and incorporation II, lipoate biosynthesis and incorporation III (Bacillus), lipoate biosynthesis and incorporation IV (yeast), lipoate biosynthesis and incorporation V (mammals), methylphosphonate degradation I, methylphosphonate degradation II, methylwyosine biosynthesis, molybdopterin biosynthesis, mycofactocin biosynthesis, paromamine biosynthesis II, phosalacine biosynthesis, phosphinothricin tripeptide biosynthesis, pyrroloquinoline quinone biosynthesis, queuosine biosynthesis III (queuosine salvage), tetrahydromethanopterin biosynthesis, thiazole component of thiamine diphosphate biosynthesis I more

Show all BRENDA pathways known for 5'-deoxyadenosine

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

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Show Natural Substrate (6 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.2.16

5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine

727637, 727008

5B7Q, 3D-view

3.2.2.9

5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine

716263

5B7Q, 3D-view

3.5.4.41

5'-deoxyadenosine + H2O = 5'-deoxyinosine + NH3

727779

-

4.1.99.26

C-terminal [mycofactocin precursor peptide MftA]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + 5'-deoxyadenosine + L-methionine + A = C-terminal [mycofactocin precursor peptide MftA]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + S-adenosyl-L-methionine + AH2

760591

-

4.1.99.26

C-terminal [mycofactocin precursor peptide MftA]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + 5'-deoxyadenosine + L-methionine + A = C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + S-adenosyl-L-methionine + AH2

760607

-

4.1.99.26

C-terminal [mycofactocin precursor peptide]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + 5'-deoxyadenosine + L-methionine + A = C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + S-adenosyl-L-methionine + AH2

773918

-

4.1.99.26

3 entries

In Vivo Product in Enzyme-catalyzed Reactions (78 results)

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Show Natural Product (78 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.98.7

S-adenosyl-L-methionine + a [Klebsiella pneumoniae sulfatase]-L-serine = [Klebsiella pneumoniae sulfatase]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine

-

-

1.1.98.7

S-adenosyl-L-methionine + a [sulfatase]-L-serine = a [sulfatase]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine

-

-

1.1.98.7

S-adenosyl-L-methionine + [periplasmic sulfatase AtsA]-L-serine = [periplasmic sulfatase AtsA]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine

-

-

1.17.98.2

2 S-adenosyl-L-methionine + a bacteriochlorophyllide c + H2O = a bacteriochlorophyllide e + 2 5'-deoxyadenosine + 2 L-methionine

-

-

1.17.98.2

S-adenosyl-L-methionine + a 7-(hydroxymethyl)bacteriochlorophyllide c + H2O = a 7-(dihydroxymethyl)bacteriochlorophyllide c + 5'-deoxyadenosine + L-methionine

-

-

1.17.98.2

S-adenosyl-L-methionine + a bacteriochlorophyllide c + H2O = a 7-(hydroxymethyl)bacteriochlorophyllide c + 5'-deoxyadenosine + L-methionine

-

-

1.1.98.7

3 entries

1.17.98.2

3 entries

1.21.98.1

dehypoxanthine futalosine + S-adenosyl-L-methionine = cyclic dehypoxanthine futalosine + 5'-deoxyadenosine + L-methionine

-

-

1.21.98.3

magnesium-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine + H2O = 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 3 L-methionine

-

-

1.21.98.4

a PqqA peptide + S-adenosyl-L-methionine = a PqqA peptide with linked Glu-Tyr residues + 5'-deoxyadenosine + L-methionine

-

-

1.21.98.4

PqqA peptide + S-adenosyl-L-methionine = PqqA peptide with linked Glu-Tyr residues + 5'-deoxyadenosine + L-methionine

-

-

1.21.98.5

2,3-bis-O-phytanyl-sn-glycerol + 2 S-adenosyl-L-methionine + reduced acceptor = macrocyclic archaeol lipid + 2 L-methionine + 2 5'-deoxyadenosine + acceptor

-

-

1.21.98.5

a 2,3-bis-O-phytanyl-sn-glycerol + 2 S-adenosyl-L-methionine + reduced acceptor = a macrocyclic archaeol lipid + 2 L-methionine + 2 5'-deoxyadenosine + acceptor

-

-

1.21.98.5

2 2,3-bis-O-phytanyl-sn-glycero-phospholipid + 4 S-adenosyl-L-methionine + 2 reduced acceptor = glycerol dibiphytanyl glycerol tetraether phospholipid + 4 L-methionine + 4 5'-deoxyadenosine + 2 acceptor

-

-

1.21.98.5

2 2,3-bis-O-phytanyl-sn-glycero-phospholipid + 4 S-adenosyl-L-methionine + 2 reduced acceptor = glycerol dibiphytanyl glycerol tetraether phospholipid + L-methionine + 4 5'-deoxyadenosine + 2 acceptor

-

-

1.21.98.5

2 2,3-bis-O-phytanyl-sn-glycerol + 4 S-adenosyl-L-methionine + 2 reduced acceptor = macrocyclic archaeol lipid + L-methionine + 4 5'-deoxyadenosine + 2 acceptor

-

-

1.21.98.5

2 a 2,3-bis-O-phytanyl-sn-glycero-phospholipid + 4 S-adenosyl-L-methionine + 2 reduced acceptor = a glycerol dibiphytanyl glycerol tetraether phospholipid + 4 L-methionine + 4 5'-deoxyadenosine + 2 acceptor

-

-

1.21.98.5

2 archaeol + 4 S-adenosyl-L-methionine + 2 reduced acceptor = glycerol trialkyl glycerol tetraether + L-methionine + 4 5'-deoxyadenosine + 2 acceptor

-

-

1.21.98.5

2 glycerol trialkyl glycerol tetraether + 4 S-adenosyl-L-methionine + 2 reduced acceptor = 2 glycerol dibiphytanyl glycerol tetraether + L-methionine + 4 5'-deoxyadenosine + 2 acceptor

-

-

1.21.98.5

2 glycerol trialkyl glycerol tetraether + 4 S-adenosyl-L-methionine + 2 reduced acceptor = glycerol dibiphytanyl glycerol tetraether + 4 L-methionine + 4 5'-deoxyadenosine + 2 acceptor

-

-

1.21.98.5

archaeol + S-adenosyl-L-methionine + reduced acceptor = glycerol trialkyl glycerol tetraether + L-methionine + 5'-deoxyadenosine + acceptor

-

-

1.3.98.3

coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine

-

-

1.3.98.3

coproporphyrinogen III + S-adenosyl-L-methionine = protoporphyrinogen IX + CO2 + L-methionine + 5'-deoxyadenosine

-

-

1.3.98.3

coproporphyrinogen-III + S-adenosyl-L-methionine = protoporphyrinogen IX + CO2 + L-methionine + 5'-deoxyadenosine

-

-

1.3.98.6

Fe-coproporphyrin III + 2 S-adenosyl-L-methionine = protoheme + 2 CO2 + 2 5'-deoxyadenosine + 2 L-methionine

-

-

1.3.98.6

Fe-coproporphyrin III + S-adenosyl-L-methionine = protoheme + CO2 + 5'-deoxyadenosine + L-methionine

-

-

1.21.98.4

2 entries

1.21.98.5

10 entries

1.3.98.3

3 entries

1.3.98.6

2 entries

1.3.98.7

C-terminal [mycofactocin precursor peptide MftA]-glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine = C-terminal [mycofactocin precursor peptide MftA]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + CO2 + 5'-deoxyadenosine + L-methionine

-

-

1.97.1.4

S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical

-

-

1.97.1.4

S-adenosyl-L-methionine + dihydroflavodoxin + [pyruvate formate-lyase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [pyruvate formate-lyase]-glycin-2-yl radical

-

-

2.1.1.192

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin

-

5HR7, 3D-view

2.1.1.192

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin

-

5HR7, 3D-view

2.1.1.192

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin

-

5HR7, 3D-view

2.1.1.192

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA

-

5HR7, 3D-view

2.1.1.192

2 S-adenosyl-L-methionine + adenine37 in tRNA + 2 reduced [2Fe-2S] ferredoxin = 2 S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine37 in tRNA + 2 oxidized [2Fe-2S] ferredoxin

-

5HR7, 3D-view

2.1.1.192

S-adenosyl-L-methionine + adenine2503 in 23S rRNA = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA

-

5HR7, 3D-view

2.1.1.224

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin

-

-

2.1.1.224

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin

-

-

2.1.1.224

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA

-

-

2.1.1.224

S-adenosyl-L-methionine + adenine2503 in 23S rRNA + reduced [2Fe-2S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + oxidized [2Fe-2S] ferredoxin

-

-

2.1.1.308

(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin = (S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin

-

-

2.1.1.308

2 S-adenosyl-L-methionine + cytidine 5'-[[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate] + reduced acceptor = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + cytidine 5'-[[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate] + oxidized acceptor

-

-

2.1.1.308

S-adenosyl-L-methionine + methylcob(III)alamin + 2-hydroxyethylphosphonate = 5'-deoxyadenosine + L-methionine + cob(III)alamin + (2S)-2-hydroxypropylphosphonate

-

-

1.97.1.4

2 entries

2.1.1.192

6 entries

2.1.1.224

4 entries

2.1.1.308

3 entries

2.1.1.326

2 S-adenosyl-L-methionine + N-acetyldemethylphosphinothricin + reduced acceptor = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + N-acetylphosphinothricin + oxidized acceptor

-

-

2.1.1.342

2 S-adenosyl-L-methionine + protoheme + 2 reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + anaerobilin + Fe2+ + 2 oxidized flavodoxin

-

-

2.1.1.379

2 S-adenosyl-L-methionine + a [methyl coenzyme-M reductase]-L-arginine285 + reduced acceptor = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + a [methyl coenzyme-M reductase]-(5S)-C-methyl-L-arginine285 + acceptor

-

-

2.1.1.379

2 S-adenosyl-L-methionine + [methyl coenzyme-M reductase subunit McrA]-L-arginine275 + reduced acceptor = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + [methyl coenzyme-M reductase subunit McrA]-(5S)-C-methyl-L-arginine275 + acceptor

-

-

2.1.1.394

(2R,3R,5S)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 2 S-adenosyl-L-methionine + reduced acceptor = (2R,3R,5S,6R)-6-(methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + acceptor

-

-

2.1.1.394

(2R,3R,5S,6R)-6-(methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 2 S-adenosyl-L-methionine + reduced acceptor = (2R,3R,5S,6R)-6-(ethyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + acceptor

-

-

2.1.1.379

2 entries

2.1.1.394

2 entries

2.3.1.311

acetyl-CoA + uridine34 in tRNA + S-adenosyl-L-methionine + H2O = CoA + 5-(carboxymethyl)uridine34 in tRNA + L-methionine + 5'-deoxyadenosine

-

-

2.5.1.147

5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine

-

-

2.6.1.B20

7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine15 in tRNA + S-adenosyl-L-methionine = 5'-deoxyadenosine + archaeosine15 in tRNA + 2 H+ + L-1-piperideine-6-carboxylate + L-methionine

-

-

2.8.1.6

dethiobiotin + sulfur + 2 S-adenosyl-L-methionine = biotin + 2 L-methionine + 2 5'-deoxyadenosine

-

-

2.8.1.6

dethiobiotin + sulfur + S-adenosyl-L-methionine = biotin + L-methionine + 5'-deoxyadenosine

-

-

2.8.1.6

dethiobiotin + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [2Fe-2S] ferredoxin

-

-

2.8.1.8

protein N6-(octanoyl)lysine + sulfur + S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + L-methionine + 5'-deoxyadenosine

-

5EXK, 3D-view

2.8.1.8

protein N6-(octanoyl)lysine + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [2Fe-2S] ferredoxin = protein N6-(lipoyl)lysine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [2Fe-2S] ferredoxin

-

5EXK, 3D-view

2.8.1.8

protein N6-(octanoyl)lysine + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [4Fe-4S] cluster = protein N6-(lipoyl)lysine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [4Fe-4S] cluster

-

5EXK, 3D-view

2.8.4.3

N6-dimethylallyladenine37 in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N6-dimethylallyladenine37 in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine

-

7MJW, 3D-view

2.8.4.3

N6-dimethylallyladenine37 in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N6-dimethylallyladenine37 in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine

-

7MJX, 3D-view

2.8.4.4

Asp89-[ribosomal protein S12] + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 3-methylthioaspartate89-[ribosomal protein S12] + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine

-

-

2.8.4.4

L-aspartate89-[ribosomal protein S12] + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + reduced acceptor = 3-methylthio-L-aspartate89-[ribosomal protein S12] + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized acceptor

-

-

2.8.4.4

L-aspartate89-[ribosomal protein S12] + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced acceptor = 3-methylthio-L-aspartate89-[ribosomal protein S12] + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized acceptor

-

-

2.8.1.6

3 entries

2.8.1.8

3 entries

2.8.4.3

2 entries

2.8.4.4

3 entries

2.8.4.5

N6-L-threonylcarbamoyladenine37 in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N6-L-threonylcarbamoyladenine37 in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine

-

-

4.1.3.44

N1-methylguanine37 in tRNAPhe + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine37 in tRNAPhe + L-methionine + 5'-deoxyadenosine + CO2 + H2O

-

-

4.1.99.14

(5''R)-alpha-5''(6''H)-bithymine + S-adenosyl-L-methionine = thymidylyl-(3'-5')-thymidylate + 5'-deoxyadenosine + L-methionine

-

-

4.1.99.14

(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine (in double helical DNA) + S-adenosyl-L-methionine + 2 H+ = thymidylyl-(3'-5')-thymidylate (in DNA) + 5'-deoxyadenosine + L-methionine

-

-

4.1.99.17

5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO

-

4S27, 3D-view

4.1.99.17

5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO

-

4S27, 3D-view

4.1.99.14

2 entries

4.1.99.17

2 entries

4.1.99.19

L-tyrosine + S-adenosyl-L-methionine + NADPH = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP+ + H+

-

-

4.1.99.22

GTP + S-adenosyl-L-methionine + reduced electron acceptor = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + oxidized electron acceptor

-

-

4.1.99.23

5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine + reduced acceptor = 5-hydroxybenzimidazole + 5'-deoxyadenosine + L-methionine + formate + NH3 + phosphate + oxidized acceptor

-

-

4.1.99.26

C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + S-adenosyl-L-methionine + AH2 = C-terminal [mycofactocin precursor peptide]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + 5'-deoxyadenosine + L-methionine + A

-

-

4.3.1.30

dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + S-adenosyl-L-methionine + reduced acceptor = dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH3 + L-methionine + 5'-deoxyadenosine + acceptor

-

-

4.3.1.30

dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + S-adenosyl-L-methionine = dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH3 + L-methionine + 5'-deoxyadenosine

-

-

4.3.1.30

2 entries

4.3.1.32

5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 7,8-didemethyl-8-hydroxy-5-deazariboflavin + NH3 + L-methionine + 5'-deoxyadenosine

-

-

4.4.1.44

pantetheine + (3S,5S)-carbapenam-3-carboxylate + S-adenosyl-L-methionine = (2R,3R,5S)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 5'-deoxyadenosine + L-methionine

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-

4.4.1.44

pantetheine + (5R)-carbapen-2-em-3-carboxylate + S-adenosyl-L-methionine = 6-desethyl-OA-6129 A + 5'-deoxyadenosine + L-methionine

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-

4.4.1.44

2 entries

4.7.1.1

alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine + reduced electron acceptor = alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + methane + L-methionine + 5'-deoxyadenosine + oxidized electron acceptor

-

-

5.3.99.13

dAMP + S-adenosyl-L-methionine = 4'-phospho-dehydrooxetanocin + 5'-deoxyadenosine + L-methionine

-

-

Substrate in Enzyme-catalyzed Reactions (15 results)

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Show Substrate (15 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.2.28

5'-deoxy-adenosine + phosphate = adenine + 5-thio-D-ribose 1 phosphate

658283

-

2.4.2.28

5'-deoxyadenosine + phosphate = adenine + 5-deoxy-D-ribose 1-phosphate

637537, 637545, 637534, 706428

-

3.2.2.1

5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine

714225

-

3.2.2.1

5'-deoxyadenosine + H2O = D-ribose + ?

326380

-

2.4.2.28

2 entries

3.2.2.1

2 entries

3.2.2.16

5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine

171784, 708504, 727637, 727008

5B7Q, 3D-view

3.2.2.26

5'-deoxyadenosine + H2O = ?

749468

-

3.2.2.30

5'-deoxyadenosine + H2O = adenine + 5-deoxyribose

749468

-

3.2.2.7

5'-deoxyadenosine + H2O = 6-aminopurine + 5-deoxy-D-ribofuranose

137099

-

3.2.2.9

5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine

716263, 716856, 751486, 758557, 769274

5B7Q, 3D-view

3.5.4.17

5'-deoxyadenosine + H2O = 5'-deoxyinosine + NH3

246708, 246709

-

3.5.4.40

5'-deoxyadenosine + H2O = ?

727029

-

3.5.4.41

5'-deoxyadenosine + H2O = 5'-deoxyinosine + NH3

727779

-

4.1.99.26

C-terminal [mycofactocin precursor peptide MftA]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + 5'-deoxyadenosine + L-methionine + A = C-terminal [mycofactocin precursor peptide MftA]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + S-adenosyl-L-methionine + AH2

760591, 759412

-

4.1.99.26

C-terminal [mycofactocin precursor peptide MftA]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + 5'-deoxyadenosine + L-methionine + A = C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + S-adenosyl-L-methionine + AH2

760607

-

4.1.99.26

C-terminal [mycofactocin precursor peptide]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + 5'-deoxyadenosine + L-methionine + A = C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + S-adenosyl-L-methionine + AH2

773918

-

4.1.99.26

3 entries

Product in Enzyme-catalyzed Reactions (173 results)

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Show Product (173 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.98.7

Ac-AVPSSIPSRASILTGM-NH2 + S-adenosyl-L-methionine + dithionite = Ac-AVPS-3-oxo-L-Ala-IPSRASILTGM-NH2 + L-methionine + 5'-deoxyadenosine + sulfur dioxide + H2O

-

-

1.1.98.7

Ac-FENAYTAVPSSIASRASILTGMS-NH2 + S-adenosyl-L-methionine = Ac-FENAYTAVPS-3-oxo-L-Ala-IASRASILTGMS-NH2 + L-methionine + 5'-deoxyadenosine

-

-

1.1.98.7

Ac-YYTSPMSAPARSMLLTGN + S-adenosyl-L-methionine = Ac-YYTSPM-3-oxo-L-Ala-APARSMLLTGN + L-methionine + 5'-deoxyadenosine

-

-

1.1.98.7

Ac-YYTSPMTAPARSMLLTGN + S-adenosyl-L-methionine = Ac-YYTSPM-(2S)-2-amino-3-oxobutanoyl-APARSMLLTGN + L-methionine + 5'-deoxyadenosine + sulfur dioxide + H2O

-

-

1.1.98.7

acetyl-Tyr-Tyr-Thr-Ser-Pro-Met-Ser-Ala-Pro-Ala-Arg-Ser-Met-Leu-Leu-Thr-Gly-Asn + S-adenosyl-L-methionine = acetyl-Tyr-Tyr-Thr-Ser-Pro-Met-3-oxo-L-Ala-Ala-Pro-Ala-Arg-Ser-Met-Leu-Leu-Thr-Gly-Asn + L-methionine + 5'-deoxyadenosine

-

-

1.1.98.7

S-adenosyl-L-methionine + a [Klebsiella pneumoniae sulfatase]-L-serine = [Klebsiella pneumoniae sulfatase]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine

-

-

1.1.98.7

S-adenosyl-L-methionine + a [sulfatase]-L-serine = a [sulfatase]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine

-

-

1.1.98.7

S-adenosyl-L-methionine + a [sulfatase]-L-serine = [sulfatase]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine

-

-

1.1.98.7

S-adenosyl-L-methionine + [Klebsiella pneumoniae sulfatase]-L-serine = [Klebsiella pneumoniae sulfatase]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine

-

-

1.1.98.7

S-adenosyl-L-methionine + [periplasmic sulfatase AtsA]-L-serine = [periplasmic sulfatase AtsA]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine

-

-

1.1.98.7

Tyr-Tyr-Thr-Ser-Pro-Met-Ser-Ala-Pro-Ala-Arg-Ser-Met-Leu-Leu-Thr-Gly-Asn + S-adenosyl-L-methionine + dithionite = Tyr-Tyr-Thr-Ser-Pro-Met-Ser-Ala-Pro-Ala-Arg-3-oxo-L-Ala-Met-Leu-Leu-Thr-Gly-Asn + L-methionine + 5'-deoxyadenosine + sulfur dioxide + H2O

-

-

1.1.98.7

[arylsulfatase]-L-serine + S-adenosyl-L-methionine + reduced acceptor = [arylsulfatase]-3-oxo-L-alanine + L-methionine + 5'-deoxyadenosine + acceptor + H2O

-

-

1.1.99.38

2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine = 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + L-methionine

-

-

1.1.99.38

2-deoxystreptamine + S-adenosyl-L-methionine = ? + 5'-deoxyadenosine + L-methionine

-

-

1.1.99.38

myo-inositol + S-adenosyl-L-methionine = ? + 5'-deoxyadenosine + L-methionine

-

-

1.1.99.38

scyllo-inositol + S-adenosyl-L-methionine = ? + 5'-deoxyadenosine + L-methionine

-

-

1.17.98.2

2 S-adenosyl-L-methionine + a bacteriochlorophyllide c + H2O = a bacteriochlorophyllide e + 2 5'-deoxyadenosine + 2 L-methionine

-

-

1.17.98.2

S-adenosyl-L-methionine + a 7-(hydroxymethyl)bacteriochlorophyllide c + H2O = a 7-(dihydroxymethyl)bacteriochlorophyllide c + 5'-deoxyadenosine + L-methionine

-

-

1.17.98.2

S-adenosyl-L-methionine + a bacteriochlorophyllide c + H2O = a 7-(hydroxymethyl)bacteriochlorophyllide c + 5'-deoxyadenosine + L-methionine

-

-

1.17.98.2

S-adenosyl-L-methionine + a bacteriochlorophyllide d + H2O = a bacteriochlorophyllide f + 5'-deoxyadenosine + L-methionine

-

-

1.1.98.7

12 entries

1.1.99.38

4 entries

1.17.98.2

4 entries

1.21.98.1

dehypoxanthine futalosine + S-adenosyl-L-methionine = cyclic dehypoxanthine futalosine + 5'-deoxyadenosine + L-methionine

-

-

1.21.98.3

magnesium-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine + H2O = 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 3 L-methionine

-

-

1.21.98.3

131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine = 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + 5'-deoxyadenosine + L-methionine

-

-

1.21.98.3

131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine = 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + L-methionine

-

-

1.21.98.3

magnesium-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine + H2O = 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + 5'-deoxyadenosine + L-methionine

-

-

1.21.98.4

a PqqA peptide + S-adenosyl-L-methionine = a PqqA peptide with linked Glu-Tyr residues + 5'-deoxyadenosine + L-methionine

-

-

1.21.98.4

PqqA peptide + S-adenosyl-L-methionine = PqqA peptide with linked Glu-Tyr residues + 5'-deoxyadenosine + L-methionine

-

-

1.21.98.5

2,3-bis-O-phytanyl-sn-glycerol + 2 S-adenosyl-L-methionine + reduced acceptor = macrocyclic archaeol lipid + 2 L-methionine + 2 5'-deoxyadenosine + acceptor

-

-

1.21.98.5

a 2,3-bis-O-phytanyl-sn-glycerol + 2 S-adenosyl-L-methionine + reduced acceptor = a macrocyclic archaeol lipid + 2 L-methionine + 2 5'-deoxyadenosine + acceptor

-

-

1.21.98.5

2 2,3-bis-O-phytanyl-sn-glycero-phospholipid + 4 S-adenosyl-L-methionine + 2 reduced acceptor = glycerol dibiphytanyl glycerol tetraether phospholipid + 4 L-methionine + 4 5'-deoxyadenosine + 2 acceptor

-

-

1.21.98.5

2 2,3-bis-O-phytanyl-sn-glycero-phospholipid + 4 S-adenosyl-L-methionine + 2 reduced acceptor = glycerol dibiphytanyl glycerol tetraether phospholipid + L-methionine + 4 5'-deoxyadenosine + 2 acceptor

-

-

1.21.98.5

2 2,3-bis-O-phytanyl-sn-glycerol + 4 S-adenosyl-L-methionine + 2 reduced acceptor = macrocyclic archaeol lipid + L-methionine + 4 5'-deoxyadenosine + 2 acceptor

-

-

1.21.98.5

2 a 2,3-bis-O-phytanyl-sn-glycero-phospholipid + 4 S-adenosyl-L-methionine + 2 reduced acceptor = a glycerol dibiphytanyl glycerol tetraether phospholipid + 4 L-methionine + 4 5'-deoxyadenosine + 2 acceptor

-

-

1.21.98.5

2 archaeol + 4 S-adenosyl-L-methionine + 2 reduced acceptor = glycerol trialkyl glycerol tetraether + L-methionine + 4 5'-deoxyadenosine + 2 acceptor

-

-

1.21.98.5

2 glycerol trialkyl glycerol tetraether + 4 S-adenosyl-L-methionine + 2 reduced acceptor = 2 glycerol dibiphytanyl glycerol tetraether + L-methionine + 4 5'-deoxyadenosine + 2 acceptor

-

-

1.21.98.5

2 glycerol trialkyl glycerol tetraether + 4 S-adenosyl-L-methionine + 2 reduced acceptor = glycerol dibiphytanyl glycerol tetraether + 4 L-methionine + 4 5'-deoxyadenosine + 2 acceptor

-

-

1.21.98.5

archaeol + S-adenosyl-L-methionine + reduced acceptor = glycerol trialkyl glycerol tetraether + L-methionine + 5'-deoxyadenosine + acceptor

-

-

1.21.98.3

4 entries

1.21.98.4

2 entries

1.21.98.5

10 entries

1.3.8.17

C-terminal [mycofactocin precursor peptide MftA]-glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine = C-terminal [mycofactocin precursor peptide MftA]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + CO2 + 5'-deoxyadenosine + L-methionine

-

-

1.3.98.3

coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine

-

-

1.3.98.3

harderoporphyrinogen + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine

-

-

1.3.98.3

2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine = 3-amino-2,3-dideoxy-scyllo-inosose + CO2 + L-methionine + 5'-deoxyadenosine

-

-

1.3.98.3

2-deoxystreptamine + S-adenosyl-L-methionine = ? + CO2 + L-methionine + 5'-deoxyadenosine

-

-

1.3.98.3

coproporphyrinogen III + S-adenosyl-L-methionine = protoporphyrinogen IX + CO2 + L-methionine + 5'-deoxyadenosine

-

-

1.3.98.3

coproporphyrinogen-III + S-adenosyl-L-methionine = protoporphyrinogen IX + CO2 + L-methionine + 5'-deoxyadenosine

-

-

1.3.98.3

harderoporphyrinogen + S-adenosyl-L-methionine = protoporphyrinogen IX + CO2 + L-methionine + 5'-deoxyadenosine

-

-

1.3.98.3

myo-inositol + S-adenosyl-L-methionine = ? + CO2 + L-methionine + 5'-deoxyadenosine

-

-

1.3.98.3

scyllo-inositol + S-adenosyl-L-methionine = ? + CO2 + L-methionine + 5'-deoxyadenosine

-

-

1.3.98.6

coproporphyrin III + 2 S-adenosyl-L-methionine = ? + 2 CO2 + 2 5'-deoxyadenosine + 2 L-methionine

-

-

1.3.98.6

Cu-coproporphyrin III + 2 S-adenosyl-L-methionine = ? + 2 CO2 + 2 5'-deoxyadenosine + 2 L-methionine

-

-

1.3.98.6

Fe-coproporphyrin III + 2 S-adenosyl-L-methionine = protoheme + 2 CO2 + 2 5'-deoxyadenosine + 2 L-methionine

-

-

1.3.98.6

Zn-coproporphyrin III + 2 S-adenosyl-L-methionine = ? + 2 CO2 + 2 5'-deoxyadenosine + 2 L-methionine

-

-

1.3.98.6

Fe-coproporphyrin III + S-adenosyl-L-methionine = protoheme + CO2 + 5'-deoxyadenosine + L-methionine

-

-

1.3.98.7

C-terminal [mycofactocin precursor peptide MftA]-glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine = C-terminal [mycofactocin precursor peptide MftA]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + CO2 + 5'-deoxyadenosine + L-methionine

-

-

1.3.98.7

C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine = C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + CO2 + 5'-deoxyadenosine + L-methionine

-

-

1.8.98.7

Ac-AVPSCIPSRASILTGM-NH2 + S-adenosyl-L-methionine + dithionite = Ac-AVPS-3-oxo-L-Ala-IPSRASILTGM-NH2 + L-methionine + 5'-deoxyadenosine + sulfur dioxide + hydrogen sulfide

-

-

1.8.98.7

Ac-FENAYTAVPSCIASRASILTGMS-NH2 + S-adenosyl-L-methionine + reduced acceptor = Ac-FENAYTAVPS-3-oxo-L-Ala-IASRASILTGMS-NH2 + L-methionine + 5'-deoxyadenosine + acceptor + hydrogen sulfide

-

-

1.8.98.7

Ac-FENAYTAVPSCIASRASILTMSQ-NH2 + S-adenosyl-L-methionine + dithionite = Ac-FENAYTAVPS-3-oxo-L-Ala-IASRASILTMSQ-NH2 + L-methionine + 5'-deoxyadenosine + sulfur dioxide + hydrogen sulfide

-

-

1.8.98.7

Ac-YTAVPSCIPSRASILTGM + S-adenosyl-L-methionine + dithionite = Ac-YTAVPS-3-oxo-L-Ala-IPSRASILTGM + L-methionine + 5'-deoxyadenosine + sulfur dioxide + hydrogen sulfide

-

-

1.8.98.7

Ac-YYTSPMCAPARSMLLTGN + S-adenosyl-L-methionine = Ac-YYTSPM-3-oxo-L-Ala-APARSMLLTGN + L-methionine + 5'-deoxyadenosine + sulfur dioxide + hydrogen sulfide

-

-

1.8.98.7

Ac-YYTSPMSAPARSMLLTGN + S-adenosyl-L-methionine = Ac-YYTSPM3-oxo-L-Ala-APARSMLLTGN + L-methionine + 5'-deoxyadenosine

-

-

1.8.98.7

Ac-YYTSPMSeCAPARSMLLTGN + S-adenosyl-L-methionine = Ac-YYTSPM-3-oxo-L-Ala-APARSMLLTGN + L-methionine + 5'-deoxyadenosine + sulfur dioxide + hydrogen selenide

-

-

1.8.98.7

Ac-YYTSPMTAPARSMLLTGN + S-adenosyl-L-methionine = Ac-YYTSPM-(2S)-2-amino-3-oxobutanoyl-APARSMLLTGN + L-methionine + 5'-deoxyadenosine + sulfur dioxide + H2O

-

-

1.8.98.7

Tyr-Tyr-Thr-Ser-Pro-Met-Cys-Ala-Pro-Ala-Arg-Ser-Met-Leu-Leu-Thr-Gly-Asn + S-adenosyl-L-methionine = Tyr-Tyr-Thr-Ser-Pro-Met-3-oxo-L-Ala-Ala-Pro-Ala-Arg-Ser-Met-Leu-Leu-Thr-Gly-Asn + L-methionine + 5'-deoxyadenosine + sulfur dioxide + hydrogen sulfide

-

-

1.97.1.4

S-adenosyl-L-methionine + 5-deazariboflavin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + 5-deazariboflavin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical

-

-

1.97.1.4

S-adenosyl-L-methionine + dihydroflavodoxin + formate acetyltransferase-glycine = 5'-deoxyadenosine + methionine + flavodoxin + formate acetyltransferase-glycine-2-yl-radical

14930, 14932, 14934, 14935, 14937, 14938, 14939, 14931, 14936, 14933, -

-

1.97.1.4

S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical

-

-

1.97.1.4

S-adenosyl-L-methionine + dihydroflavodoxin + [pyruvate formate-lyase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [pyruvate formate-lyase]-glycin-2-yl radical

-

-

1.97.1.4

S-adenosyl-L-methionine + dihydroflavodoxin + [pyruvate formate-lyase]-glycine = methionine + 5'-deoxyadenosine + [pyruvate formate-lyase]-glycine radical + flavodoxin

-

-

1.97.1.4

S-adenosyl-L-methionine + NADH + formate acetyltransferase-glycine = 5'-deoxyadenosine + methionine + NAD+ + formate acetyltransferase-glycine-2-yl-radical

-

-

1.97.1.4

S-adenosyl-L-methionine + NADPH + formate acetyltransferase-glycine = 5'-deoxyadenosine + methionine + NADP+ + formate acetyltransferase-glycine-2-yl-radical

-

-

1.97.1.4

S-adenosyl-L-methionine + reduced methyl viologen + formate acetyltransferase-glycine = 5'-deoxyadenosine + methionine + methyl viologen + formate acetyltransferase-glycine-2-yl-radical

-

-

2.1.1.192

2 S-adenosyl-L-methionine + adenine in 155mer RNA = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine in 155mer RNA

-

5HR7, 3D-view

2.1.1.192

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin

-

5HR7, 3D-view

2.1.1.192

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin

-

5HR7, 3D-view

2.1.1.192

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin

-

5HR7, 3D-view

2.1.1.192

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA

-

5HR7, 3D-view

2.1.1.192

2 S-adenosyl-L-methionine + adenine37 in tRNA + 2 reduced [2Fe-2S] ferredoxin = 2 S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine37 in tRNA + 2 oxidized [2Fe-2S] ferredoxin

-

5HR7, 3D-view

2.1.1.192

2 S-adenosyl-L-methionine + adenine37 in tRNAArg(ACG) + 2 reduced [2Fe-2S] ferredoxin = 2 S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine37 in tRNAArg(ACG) + 2 oxidized [2Fe-2S] ferredoxin

-

5HR7, 3D-view

2.1.1.192

2 S-adenosyl-L-methionine + adenine37 in tRNAAsp(GUC) + 2 reduced [2Fe-2S] ferredoxin = 2 S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine37 in tRNAAsp(GUC) + 2 oxidized [2Fe-2S] ferredoxin

-

5HR7, 3D-view

2.1.1.192

2 S-adenosyl-L-methionine + adenine37 in tRNAGln(CUG) + 2 reduced [2Fe-2S] ferredoxin = 2 S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine37 in tRNAGln(CUG) + 2 oxidized [2Fe-2S] ferredoxin

-

5HR7, 3D-view

2.1.1.192

2 S-adenosyl-L-methionine + adenine37 in tRNAGln(UUG) + 2 reduced [2Fe-2S] ferredoxin = 2 S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine37 in tRNAGln(UUG) + 2 oxidized [2Fe-2S] ferredoxin

-

5HR7, 3D-view

2.1.1.192

2 S-adenosyl-L-methionine + adenine37 in tRNAGlu(UUC) + 2 reduced [2Fe-2S] ferredoxin = 2 S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine37 in tRNAGlu(UUC) + 2 oxidized [2Fe-2S] ferredoxin

-

5HR7, 3D-view

2.1.1.192

2 S-adenosyl-L-methionine + adenine37 in tRNAHis(GUG) + 2 reduced [2Fe-2S] ferredoxin = 2 S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine37 in tRNAHis(GUG) + 2 oxidized [2Fe-2S] ferredoxin

-

5HR7, 3D-view

2.1.1.192

S-adenosyl-L-methionine + adenine2503 in 23S rRNA = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA

-

5HR7, 3D-view

2.1.1.224

2 S-adenosyl-L-methionine + 2-methyladenine2503 in 23S rRNA = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2,8-dimethyladenine2503 in 23S rRNA

-

-

2.1.1.224

2 S-adenosyl-L-methionine + 2-methyladenine2503 in 23S rRNA fragment (2447-2625) = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2,8-dimethyladenine2503 in 23S rRNA fragment (2447-2625)

-

-

2.1.1.224

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin

-

-

2.1.1.224

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin

-

-

2.1.1.224

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA

-

-

2.1.1.224

S-adenosyl-L-methionine + adenine2503 in 23S rRNA + reduced [2Fe-2S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + oxidized [2Fe-2S] ferredoxin

-

-

2.1.1.308

(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin = (S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin

-

-

2.1.1.308

2 S-adenosyl-L-methionine + cytidine 5'-[[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate] + reduced acceptor = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + cytidine 5'-[[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate] + oxidized acceptor

-

-

2.1.1.308

S-adenosyl-L-methionine + cytidine 5'-[[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate] + reduced methyl viologen = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + cytidine 5'-[[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate] + oxidized methyl viologen

-

-

2.1.1.308

S-adenosyl-L-methionine + methylcob(III)alamin + 2-hydroxyethylphosphonate = 5'-deoxyadenosine + L-methionine + cob(III)alamin + (2S)-2-hydroxypropylphosphonate

-

-

2.1.1.326

2 S-adenosyl-L-methionine + demethylphosphinothricin + reduced acceptor = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + phosphinothricin + oxidized acceptor

-

-

2.1.1.326

2 S-adenosyl-L-methionine + N-acetyldemethylphosphinothricin + reduced acceptor = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + N-acetylphosphinothricin + oxidized acceptor

-

-

2.1.1.326

S-adenosyl-L-methionine + N-acetyldemethyl phosphinothricin tripeptide + reduced acceptor = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + N-acetylphosphinothricin tripeptide + oxidized acceptor

-

-

2.1.1.326

S-adenosyl-L-methionine + N-acetyldemethylphosphinothricin + reduced acceptor = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + N-acetylphosphinothricin + oxidized acceptor

-

-

2.1.1.342

2 S-adenosyl-L-methionine + heme + 2 reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + ? + Fe2+ + 2 oxidized flavodoxin

-

-

2.1.1.342

2 S-adenosyl-L-methionine + mesoheme + 2 reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + ? + Fe2+ + 2 oxidized flavodoxin

-

-

2.1.1.342

2 S-adenosyl-L-methionine + protoheme + 2 reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + anaerobilin + Fe2+ + 2 oxidized flavodoxin

-

-

2.1.1.350

2 S-adenosyl-L-methionine + 2-demethylmenaquinone-8 + reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-demethyl-8-methylmenaquinone-8 + 2-demethyl-5,8-dimethylmenaquinone-8 + oxidized flavodoxin

-

-

2.1.1.350

2 S-adenosyl-L-methionine + menaquinone-6 + reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methylmenaquinone-6 + oxidized flavodoxin

-

-

2.1.1.350

2 S-adenosyl-L-methionine + menaquinone-8 + reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 7-methylmenaquinone-8 + oxidized flavodoxin

-

-

2.1.1.350

2 S-adenosyl-L-methionine + menaquinone-8 + reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methylmenaquinone-8 + 5,8-dimethylmenaquinone-8 + oxidized flavodoxin

-

-

2.1.1.350

2 S-adenosyl-L-methionine + menaquinone-8 + reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methylmenaquinone-8 + oxidized flavodoxin

-

-

2.1.1.379

2 S-adenosyl-L-methionine + a [methyl coenzyme-M reductase]-L-arginine285 + reduced acceptor = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + a [methyl coenzyme-M reductase]-(5S)-C-methyl-L-arginine285 + acceptor

-

-

2.1.1.379

2 S-adenosyl-L-methionine + [methyl coenzyme-M reductase subunit McrA]-L-arginine275 + reduced acceptor = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + [methyl coenzyme-M reductase subunit McrA]-(5S)-C-methyl-L-arginine275 + acceptor

-

-

2.1.1.394

(2R,3R,5S)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 2 S-adenosyl-L-methionine + reduced acceptor = (2R,3R,5S,6R)-6-(methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + acceptor

-

-

2.1.1.394

(2R,3R,5S,6R)-6-(methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 2 S-adenosyl-L-methionine + reduced acceptor = (2R,3R,5S,6R)-6-(ethyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + acceptor

-

-

1.3.98.3

9 entries

1.3.98.6

5 entries

1.3.98.7

2 entries

1.8.98.7

9 entries

1.97.1.4

8 entries

2.1.1.192

13 entries

2.1.1.224

6 entries

2.1.1.308

4 entries

2.1.1.326

4 entries

2.1.1.342

3 entries

2.1.1.350

5 entries

2.1.1.379

2 entries

2.1.1.394

2 entries

2.3.1.181

Glu-Ser-Val-(N6-octanoyl)Lys-Ala-Ala-Ser-Asp + S-adenosyl methionine = Glu-Ser-Val-(8-mercaptooctanoyl)Lys-Ala-Ala-Ser-Asp + 5'-deoxyadenosine

-

-

2.3.1.311

acetyl-CoA + uridine34 in tRNA + S-adenosyl-L-methionine + H2O = CoA + 5-(carboxymethyl)uridine34 in tRNA + L-methionine + 5'-deoxyadenosine

-

-

2.5.1.147

5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + L-methionine + 5'-deoxyadenosine

-

-

2.6.1.B20

7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine15 in tRNA + S-adenosyl-L-methionine = 5'-deoxyadenosine + archaeosine15 in tRNA + 2 H+ + L-1-piperideine-6-carboxylate + L-methionine

-

-

2.7.1.77

5'-dAMP + thymidine = 5'-deoxyadenosine + TMP

-

-

2.8.1.6

dethiobiotin + sulfur + 2 S-adenosyl-L-methionine = biotin + 2 L-methionine + 2 5'-deoxyadenosine

-

-

2.8.1.6

dethiobiotin + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin

-

-

2.8.1.6

dethiobiotin + [S] + 2 S-adenosyl-L-methionine = biotin + 2 L-methionine + 2 5'-deoxyadenosine

-

-

2.8.1.6

9-mercaptodethiobiotin + [S] + S-adenosyl-L-methionine = biotin + L-methionine + 5'-deoxyadenosine

-

-

2.8.1.6

dethiobiotin + sulfur + S-adenosyl-L-methionine = biotin + L-methionine + 5'-deoxyadenosine

-

-

2.8.1.6

dethiobiotin + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [2Fe-2S] ferredoxin

-

-

2.8.1.6

dethiobiotin + [S] + S-adenosyl-L-methionine = 9-mercaptodethiobiotin + L-methionine + 5'-deoxyadenosine

-

-

2.8.1.6

dethiobiotin + [S] + S-adenosyl-L-methionine = biotin + L-methionine + 5'-deoxyadenosine

-

-

2.8.1.8

[protein]-N6-(octanoyl)-L-lysine + an [Fe-S] cluster scaffold protein carrying a [4Fe-4S]2+ cluster + 2 S-adenosyl-L-methionine + 2 oxidized [2Fe-2S] ferredoxin + 6 H+ = [protein]-N6-[(R)-dihydrolipoyl]-L-lysine + an [Fe-S] cluster scaffold protein + 2 sulfide + 4 Fe3+ + 2 L-methionine + 2 5'-deoxyadenosine + 2 reduced [2Fe-2S] ferredoxin

-

5EXK, 3D-view

2.8.1.8

protein N6-(octanoyl)lysine + sulfur + S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl radicals

-

5EXK, 3D-view

2.8.1.8

biotin-PEG-Glu-Ser-Val-([8,8,8-2H3]-N6-octanoyl)Lys-Ala-Ala-Ser-Asp + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [4Fe-4S] ferredoxin = biotin-PEG-Glu-Ser-Val-([8,8,8-2H3]-N6-lipoyl)Lys-Ala-Ala-Ser-Asp + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [4Fe-4S] ferredoxin

-

5EXK, 3D-view

2.8.1.8

Glu-Ser-Val-(N6-mercaptooctanoyl)Lys-Ala-Ala-Ser-Asp + S-adenosyl-L-methionine = ? + 5'-deoxyadenosine

-

5EXK, 3D-view

2.8.1.8

Glu-Ser-Val-(N6-octanoyl)Lys-Ala-Ala-Ser-Asp + S-adenosyl-L-methionine = ? + 5'-deoxyadenosine

-

5EXK, 3D-view

2.8.1.8

Glu-Ser-Val-(N6-octanoyl)Lys-Ala-Ala-Ser-Asp + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [4Fe-4S] dithionite = Glu-Ser-Val-(N6-lipoyl)Lys-Ala-Ala-Ser-Asp + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [4Fe-4S] dithionite

-

5EXK, 3D-view

2.8.1.8

Glu-Ser-Val-(N8-mercaptooctanoyl)Lys-Ala-Ala-Ser-Asp + S-adenosyl-L-methionine = ? + 5'-deoxyadenosine

-

5EXK, 3D-view

2.8.1.8

H protein N6-(octanoyl)lysine + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [2Fe-2S] dithionite = H protein N6-(lipoyl)lysine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [2Fe-2S] dithionite

-

5EXK, 3D-view

2.8.1.8

H protein N6-(octanoyl)lysine + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [2Fe-2S] flavodoxin = H protein N6-(lipoyl)lysine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [2Fe-2S] flavodoxin

-

5EXK, 3D-view

2.8.1.8

protein N6-(octanoyl)lysine + sulfur + S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + L-methionine + 5'-deoxyadenosine

-

5EXK, 3D-view

2.8.1.8

protein N6-(octanoyl)lysine + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [2Fe-2S] ferredoxin = protein N6-(lipoyl)lysine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [2Fe-2S] ferredoxin

-

5EXK, 3D-view

2.8.1.8

protein N6-(octanoyl)lysine + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [4Fe-4S] cluster = protein N6-(lipoyl)lysine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [4Fe-4S] cluster

-

5EXK, 3D-view

2.8.1.8

[8,8,8-2H3]-octanoyl-H protein + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced [4Fe-4S] dithionite = [8,8,8-2H3]-lipoyl-H protein + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized [4Fe-4S] dithionite

-

5EXK, 3D-view

2.8.1.8

protein N6-(octanoyl)lysine + sulfur + S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 5'-deoxyadenosyl radical

-

5EXK, 3D-view

2.8.1.8

protein N6-(octanoyl)lysine + sulfur + S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + L-methionine + 5'-deoxyadenosyl radicals

-

5EXK, 3D-view

2.8.4.3

N6-dimethylallyladenine in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N6-dimethylallyladenine in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine

-

7MJW, 3D-view

2.8.4.3

N6-dimethylallyladenine in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N6-dimethylallyladenine in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine

-

7MJX, 3D-view

2.8.4.3

N6-dimethylallyladenine37 in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N6-dimethylallyladenine37 in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine

-

7MJW, 3D-view

2.8.4.3

N6-dimethylallyladenine37 in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N6-dimethylallyladenine37 in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine

-

7MJX, 3D-view

2.8.4.3

N6-dimethylallyladenine37 in tRNA + sulfur-(sulfur carrier) + S-adenosyl-L-methionine = 2-thio-N6-dimethylallyladenine37 in tRNA + (sulfur carrier) + L-methionine + 5'-deoxyadenosine

-

7MJW, 3D-view

2.8.4.3

N6-dimethylallyladenine37 in tRNA + sulfur-(sulfur carrier) + S-adenosyl-L-methionine = 2-thio-N6-dimethylallyladenine37 in tRNA + (sulfur carrier) + L-methionine + 5'-deoxyadenosine

-

7MJX, 3D-view

2.8.4.4

3-methylthioaspartate89-[ribosomal protein S12 20mer peptide] + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 3,3-bismethylthioaspartate89-[ribosomal protein S12 20mer peptide] + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine

-

-

2.8.4.4

Asp88-[ribosomal protein S12] + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 3-methylthioaspartate88-[ribosomal protein S12] + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine

-

-

2.8.4.4

Asp89-[ribosomal protein S12 20mer peptide] + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 3-methylthioaspartate89-[ribosomal protein S12 20mer peptide] + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine

-

-

2.8.4.4

Asp89-[ribosomal protein S12] + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 3-methylthioaspartate89-[ribosomal protein S12] + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine

-

-

2.8.4.4

L-aspartate89-[ribosomal protein S12] + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + reduced acceptor = 3-methylthio-L-aspartate89-[ribosomal protein S12] + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized acceptor

-

-

2.8.4.4

L-aspartate89-[ribosomal protein S12] + sulfur-(sulfur carrier) + S-adenosyl-L-methionine + reduced acceptor = 3-methylthio-L-aspartate89-[ribosomal protein S12] + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + oxidized acceptor

-

-

2.8.4.4

N6-dimethylallyladenine37 in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N6-dimethylallyladenine37 in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine

-

-

2.8.1.6

8 entries

2.8.1.8

15 entries

2.8.4.3

6 entries

2.8.4.4

7 entries

2.8.4.5

N6-L-threonylcarbamoyladenine37 in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N6-L-threonylcarbamoyladenine37 in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine

-

-

4.1.3.44

N1-methylguanine37 in tRNAPhe + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine37 in tRNAPhe + L-methionine + 5'-deoxyadenosine + CO2 + H2O

-

-

4.1.99.14

(5''R)-alpha-5''(6''H)-bithymine + S-adenosyl-L-methionine = thymidylyl-(3'-5')-thymidylate + 5'-deoxyadenosine + L-methionine

-

-

4.1.99.14

(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine (in double helical DNA) + S-adenosyl-L-methionine + 2 H+ = thymidylyl-(3'-5')-thymidylate (in DNA) + 5'-deoxyadenosine + L-methionine

-

-

4.1.99.14

(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine + S-adenosyl-L-methionine = thymidylyl-(3'->5')-thymidylate + 5'-deoxyadenosine + L-methionine

-

-

4.1.99.14

5-thyminyl-5,6 dihydrothymine + S-adenosyl-L-methionine = thymidylyl-(3'-5')-thymidylate + 5'-deoxyadenosine + L-methionine

-

-

4.1.99.17

5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO

-

4S27, 3D-view

4.1.99.17

5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO

-

4S27, 3D-view

4.1.99.19

L-tyrosine + S-adenosyl-L-methionine + NADPH = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP+ + H+

-

-

4.1.99.19

L-tyrosine + S-adenosyl-L-methionine + reduced acceptor = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H+

-

-

4.1.99.22

GMP[CH2]PP + S-adenosyl-L-methionine + reduced electron acceptor = (8S)-3',8-cyclo-7,8-dihydroguanosine-P[CH2]PP + 5'-deoxyadenosine + L-methionine + oxidized electron acceptor

-

-

4.1.99.22

GTP + S-adenosyl-L-methionine + reduced electron acceptor = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + oxidized electron acceptor

-

-

4.1.99.14

4 entries

4.1.99.17

2 entries

4.1.99.19

2 entries

4.1.99.22

2 entries

4.1.99.23

5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine + reduced acceptor = 5-hydroxybenzimidazole + 5'-deoxyadenosine + L-methionine + formate + NH3 + phosphate + oxidized acceptor

-

-

4.1.99.26

C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + S-adenosyl-L-methionine + AH2 = C-terminal [mycofactocin precursor peptide]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + 5'-deoxyadenosine + L-methionine + A

-

-

4.3.1.30

dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + S-adenosyl-L-methionine + reduced acceptor = dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH3 + L-methionine + 5'-deoxyadenosine + acceptor

-

-

4.3.1.30

dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + S-adenosyl-L-methionine = dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH3 + L-methionine + 5'-deoxyadenosine

-

-

4.3.1.30

dTDP-4-amino-4,6-dideoxy-D-glucopyranose + S-adenosyl-L-methionine = dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH3 + L-methionine + 5'-deoxyadenosine

-

-

4.3.1.30

3 entries

4.3.1.32

5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 7,8-didemethyl-8-hydroxy-5-deazariboflavin + NH3 + L-methionine + 5'-deoxyadenosine

-

-

4.4.1.44

pantetheine + (3S,5S)-carbapenam-3-carboxylate + S-adenosyl-L-methionine = (2R,3R,5S)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + 5'-deoxyadenosine + L-methionine

-

-

4.4.1.44

pantetheine + (5R)-carbapen-2-em-3-carboxylate + S-adenosyl-L-methionine = 6-desethyl-OA-6129 A + 5'-deoxyadenosine + L-methionine

-

-

4.4.1.44

2 entries

4.7.1.1

alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine + reduced electron acceptor = alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + methane + L-methionine + 5'-deoxyadenosine + oxidized electron acceptor

-

-

5.3.99.13

dAMP + S-adenosyl-L-methionine = 4'-phospho-dehydrooxetanocin + 5'-deoxyadenosine + L-methionine

-

-

Inhibitor in Enzyme-catalyzed Reactions (11 results)

top print hide

Show Inhibitors (11 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.4.2.28

and analogues; strong, competitive

637545

-

2.7.1.20

10-90% inhibition at 0.01 mM

685030

-

2.7.1.20

100% inhibition

641083

-

2.7.1.20

adenosine phosphorylation is inhibited by 100fold excess of the inhibitor

675871

-

2.7.1.20

3 entries

2.7.11.14

-

640699

-

2.8.1.6

competitive, inhibits the growth of Mycobacterium tuberculosis H37Ra with an MIC of 392.6 microg/ml

762502

-

2.8.1.6

product inhibition. The combination of both products in equimolar concentrations results in more than simple additive inhibition, suggesting that they bind cooperatively to the enzyme.

724296

-

2.8.1.6

strong inhibitor, reversible, 90% inhibition upon addition of 1 equivalent of 5'-deoxyadenosine with regard to the enzyme

645608

-

2.8.1.6

3 entries

3.13.2.1

-

137127

-

4.1.99.17

cooperative inhibition by with Met

727960

4S27, 3D-view

6.3.5.2

-

1361, 1372

-

3D Structure of Enzyme-Ligand-Complex (PDB) (109 results)

top print hide

Show 3D Structure of Enzyme-Ligand-Complex (PDB) (109 entries)

EC NUMBER

ENZYME 3D STRUCTURE

1.17.4.1

3O0O, 3D-view

2.1.1.192

5HR7, 3D-view

2.3.1.48

6QK7, 3D-view

2.5.1.15

5Z79, 3D-view

2.5.1.17

3CI3, 3D-view

2.5.1.17

6D5K, 3D-view

2.5.1.17

6D5X, 3D-view

2.5.1.17

6WGS, 3D-view

2.5.1.17

6WGV, 3D-view

2.5.1.17

7RUU, 3D-view

2.5.1.17

7RUV, 3D-view

2.5.1.17

8D32, 3D-view

2.5.1.17

3CI3, 3D-view

2.5.1.17

6D5K, 3D-view

2.5.1.17

6D5X, 3D-view

2.5.1.17

6WGS, 3D-view

2.5.1.17

6WGV, 3D-view

2.5.1.17

7RUU, 3D-view

2.5.1.17

7RUV, 3D-view

2.5.1.17

8D32, 3D-view

2.5.1.17

3CI3, 3D-view

2.5.1.17

6D5K, 3D-view

2.5.1.17

6D5X, 3D-view

2.5.1.17

6WGS, 3D-view

2.5.1.17

6WGV, 3D-view

2.5.1.17

7RUU, 3D-view

2.5.1.17

7RUV, 3D-view

2.5.1.17

8D32, 3D-view

2.5.1.17

3CI3, 3D-view

2.5.1.17

6D5K, 3D-view

2.5.1.17

6D5X, 3D-view

2.5.1.17

6WGS, 3D-view

2.5.1.17

6WGV, 3D-view

2.5.1.17

7RUU, 3D-view

2.5.1.17

7RUV, 3D-view

2.5.1.17

8D32, 3D-view

2.5.1.17

32 entries

2.5.1.63

2CC2, 3D-view

2.7.6.3

5Z79, 3D-view

2.8.1.8

5EXK, 3D-view

2.8.4.3

7MJW, 3D-view

2.8.4.3

7MJX, 3D-view

2.8.4.3

7MJW, 3D-view

2.8.4.3

7MJX, 3D-view

2.8.4.3

7MJW, 3D-view

2.8.4.3

7MJX, 3D-view

2.8.4.3

7MJW, 3D-view

2.8.4.3

7MJX, 3D-view

2.8.4.3

8 entries

3.2.2.16

5B7Q, 3D-view

3.2.2.9

5B7Q, 3D-view

4.1.99.17

4S27, 3D-view

4.2.1.28

5YRT, 3D-view

4.2.1.28

5YRV, 3D-view

4.2.1.28

5YSH, 3D-view

4.2.1.28

5YRT, 3D-view

4.2.1.28

5YRV, 3D-view

4.2.1.28

5YSH, 3D-view

4.2.1.28

5YRT, 3D-view

4.2.1.28

5YRV, 3D-view

4.2.1.28

5YSH, 3D-view

4.2.1.28

5YRT, 3D-view

4.2.1.28

5YRV, 3D-view

4.2.1.28

5YSH, 3D-view

4.3.1.7

5YSN, 3D-view

4.3.1.7

5YSR, 3D-view

4.3.1.7

5YSN, 3D-view

4.3.1.7

5YSR, 3D-view

4.3.1.7

5YSN, 3D-view

4.3.1.7

5YSR, 3D-view

4.3.1.7

5YSN, 3D-view

4.3.1.7

5YSR, 3D-view

4.2.1.28

12 entries

4.3.1.7

8 entries

5.4.3.3

1XRS, 3D-view

5.4.99.1

1I9C, 3D-view

5.4.99.13

4XC6, 3D-view

5.4.99.2

2XIJ, 3D-view

5.4.99.2

2XIQ, 3D-view

5.4.99.2

4REQ, 3D-view

5.4.99.2

5CJT, 3D-view

5.4.99.2

5CJU, 3D-view

5.4.99.2

5CJV, 3D-view

5.4.99.2

5CJW, 3D-view

5.4.99.2

6OXC, 3D-view

5.4.99.2

6OXD, 3D-view

5.4.99.2

2XIJ, 3D-view

5.4.99.2

2XIQ, 3D-view

5.4.99.2

4REQ, 3D-view

5.4.99.2

5CJT, 3D-view

5.4.99.2

5CJU, 3D-view

5.4.99.2

5CJV, 3D-view

5.4.99.2

5CJW, 3D-view

5.4.99.2

6OXC, 3D-view

5.4.99.2

6OXD, 3D-view

5.4.99.2

2XIJ, 3D-view

5.4.99.2

2XIQ, 3D-view

5.4.99.2

4REQ, 3D-view

5.4.99.2

5CJT, 3D-view

5.4.99.2

5CJU, 3D-view

5.4.99.2

5CJV, 3D-view

5.4.99.2

5CJW, 3D-view

5.4.99.2

6OXC, 3D-view

5.4.99.2

6OXD, 3D-view

5.4.99.2

2XIJ, 3D-view

5.4.99.2

2XIQ, 3D-view

5.4.99.2

4REQ, 3D-view

5.4.99.2

5CJT, 3D-view

5.4.99.2

5CJU, 3D-view

5.4.99.2

5CJV, 3D-view

5.4.99.2

5CJW, 3D-view

5.4.99.2

6OXC, 3D-view

5.4.99.2

6OXD, 3D-view

5.4.99.2

36 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (13 results)

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Show Turnover Number (13 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.4.2.28

4.8

-

-

658283

3.2.2.1

0.078

-

at pH 7.0 and 35°C

714225

3.2.2.26

0.92

-

at pH 7.4 and 25°C

749468

3.2.2.30

0.92

-

pH 7.4, 25°C

749468

3.2.2.9

0.47

-

pH and temperature not specified in the publication

758557

3.2.2.9

0.73

-

pH 7.0, temperature not specified in the publication

769274

3.2.2.9

1.53

-

pH 7.0, temperature not specified in the publication

769274

3.2.2.9

2.7

-

pH 5.0, temperature not specified in the publication

769274

3.2.2.9

4 entries

3.5.4.40

0.017

-

wild type enzyme, at pH 7.5 and at 30°C

727029

3.5.4.41

1.12

-

pH and temperature not specified in the publication, mutant enzyme Y136R/E150R

727779

3.5.4.41

21

-

pH and temperature not specified in the publication, mutant enzyme E150R

727779

3.5.4.41

330

-

pH and temperature not specified in the publication, mutant enzyme Y136R

727779

3.5.4.41

120000

-

pH and temperature not specified in the publication, wild-type enzyme

727779

3.5.4.41

4 entries

K_M Value (17 results)

top print hide

Show KM Value (17 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.4.2.28

0.0043

-

-

637545

2.4.2.28

0.006

-

-

658283

2.4.2.28

0.023

-

-

637535

3.2.2.1

0.24

-

at pH 7.0 and 35°C

714225

3.2.2.1

9.87

-

-

326380

2.4.2.28

3 entries

3.2.2.1

2 entries

3.2.2.26

0.0214

-

at pH 7.4 and 25°C

749468

3.2.2.30

0.0214

-

pH 7.4, 25°C

749468

3.2.2.9

0.00137

-

pH 5.0, temperature not specified in the publication

769274

3.2.2.9

0.00179

-

pH 7.0, temperature not specified in the publication

769274

3.2.2.9

0.01046

-

pH 7.0, temperature not specified in the publication

769274

3.2.2.9

0.0109

-

pH and temperature not specified in the publication

758557

3.2.2.9

4 entries

3.5.4.17

0.65

-

-

246708

3.5.4.40

0.042

-

wild type enzyme, at pH 7.5 and at 30°C

727029

3.5.4.41

0.014

-

pH and temperature not specified in the publication, wild-type enzyme

727779

3.5.4.41

0.021

-

pH and temperature not specified in the publication, mutant enzyme E150R

727779

3.5.4.41

0.032

-

pH and temperature not specified in the publication, mutant enzyme Y136R

727779

3.5.4.41

0.05

-

pH and temperature not specified in the publication, mutant enzyme Y136R/E150R

727779

3.5.4.41

4 entries

K_i Value (3 results)

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Show KI Value (3 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.11.14

0.01

-

pH 7.5, 25°C

640699

2.8.1.6

0.0242

-

pH 8.0, 37°C

762502

4.1.99.17

0.012

-

pH 8.0, 37°C, recombinant His-tagged enzyme

727960

IC₅₀ Value (1 result)

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Show IC50 Value (1 entry)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

2.8.1.6

0.2674

-

pH 8.0, 37°C

762502

References & Links

Literature References (54)

top print hide

Show Reference (54 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

1361

188467

Guanosine monophosphate synthetase from Ehrlich ascites cells. Multiple inhibition by pyrophosphate and nucleosides

1976

Spector, T.; Jones, T.E.; Krenitsky, T.A.; Harvey, R.J.

Biochim. Biophys. Acta

452

597-607

1372

7706277

Biochemical characterization of human GMP synthetase

1995

Nakamura, J.; Lou, L.

J. Biol. Chem.

270

7347-7353

14930

-

Novel roles for Fe-S clusters in stabilizing or generating radical intermediates

1998

Johnson, M.K.; Staples, C.R.; Duin, E.C.; Lafferty, M.E.; Duderstadt, R.E.

Pure Appl. Chem.

70

939-946

14931

8636053

Molecular characterization of the genes encoding pyruvate formate-lyase and its activating enzyme of Clostridium pasteurianum

1996

Weidner, G.; Sawers, G.

J. Bacteriol.

178

2440-2444

14932

9478932

Reconstitution and characterization of the polynuclear iron-sulfur cluster in pyruvate formate-lyase-activating enzyme. Molecular properties of the holoenzyme form

1998

Kulzer, R.; Pils, T.; Kappl, R.; Huttermann, J.; Knappe, J.

J. Biol. Chem.

273

4897-4903

14933

8175649

Adenosylmethionine-dependent synthesis of the glycyl radical in pyruvate formate-lyase by abstraction of the glycine C-2 pro-S hydrogen atom

1994

Frey, M.; Rothe, M.; Wagner, A.F.V.; Knappe, J.

J. Biol. Chem.

269

12432-12437

14934

8260492

Molecular properties of pyruvate formate-lyase activating enzyme

1993

Wong, K.K.; Murray, B.W.; Lewisch, S.A.; Baxter, M.K.; Ridky, T.W.; Ulissi-DeMario, L.; Kozarich, J.W.

Biochemistry

32

14102-14110

14935

9918833

A dehydroalanyl residue can capture the 5'-deoxyadenosyl radical generated from S-adenosylmethionine by pyruvate formate-lyase-activating enzyme

1999

Wagner, A.F.V.; Demand, J.; Schilling, G.; Pils, T.; Knappe, J.

Biochem. Biophys. Res. Commun.

254

306-310

14936

6364987

Pyruvate formate-lyase (inactive form) and pyruvate formate-lyase activating enzyme of Escherichia coli: isolation and structural properties

1984

Conradt, H.; Hohmann-Berger, M.; Hohmann, H.P.; Blaschkowski, H.P.; Knappe, J.

Arch. Biochem. Biophys.

228

133-142

14937

3053170

Primary structures of Escherichia coli pyruvate formate-lyase and pyruvate-formate-lyase-activating enzyme deduced from the DNA nucleotide sequences

1988

Rödel, W.; Plaga, W.; Frank, W.; Knappe, J.

Eur. J. Biochem.

177

153-158

14938

9767563

A glycyl radical solution: oxygen-dependent interconversion of pyruvate formate-lyase

1998

Sawers, G.; Watson, G.

Mol. Microbiol.

29

945-954

14939

9484901

Novel keto acid formate-lyase and propionate kinase enzynes are components of an anaerobic pathway in Escherichia coli that degrades L-threonine to propionate

1998

Hesslinger, C.; Fairhurst, S.A.; Sawers, G.

Mol. Microbiol.

27

477-492

137099

-

Isolation and characterization of adenosine nucleosidase from yellow lupin (Lupinus luteus)

2000

Abusamhadneh, E.; McDonald, N.E.; Kline, P.C.

Plant Sci.

153

25-32

137127

6428887

Occurrence of S-adenosylhomocysteine hydrolase in prokaryote cells. Characterization of the enzyme from Alcaligenes faecalis and role of the enzyme in the activated methyl cycle

1984

Shimizu, S.; Shiozaki, S.; Ohshiro, T.; Yamada, H.

Eur. J. Biochem.

141

385-392

171784

6783408

5'-Methylthioadenosine nucleosidase. Purification and characterization of the enzyme from Lupinus luteus seeds

1981

Guranowski, A.B.; Chiang, P.K.; Cantoni, G.L.

Eur. J. Biochem.

114

293-299

246708

-

Distribution of adenosine (phosphate) deaminases with unusual substrate specificity in marine mollusc

1998

Uchida, H.; Chen, Y.X.; Nagai, H.; Fujisaki, Y.; Harihara, K.; Saka, N.; Kugisaki, Y.; Nomura, A.

Comp. Biochem. Physiol. B

119

227-233

246709

-

Recognition of ribose moiety by adenosine (phosphate) deaminase from squid liver

1995

Uchida, H.; Narita, Y.; Masuda, A.; Chen, Y.X.; Nomura, A.

Biosci. Biotechnol. Biochem.

59

2120-2122

326380

8702965

Purine-specific nucleoside N-ribohydrolase from Trypanosoma brucei brucei

1996

Parkin, D.W.

J. Biol. Chem.

271

21713-21719

637534

-

5'-Methyladenosine (MTA) phosphorylase from promastigotes of Leishmania donovani

1986

Koszalka, G.W.; Krenitsky, T.A.

Adv. Exp. Med. Biol.

195B

559-563

637535

6802139

Structural analogs of 5'-methylthioadenosine as substrates and inhibitors of 5'-methylthioadenosine phosphorylase and as inhibitors of human lymphocyte transformation

1982

White, M.W.; Vandenbark, A.A.; Barney, C.L.; Ferro, A.J.

Biochem. Pharmacol.

31

503-507

637537

6164373

5'-Methylthioadenosine phosphorylase. I. Substrate activity of 5'-deoxyadenosine with the enzyme from Sarcoma 180 cells

1981

Savarese, T.M.; Crabtree, G.W.; Parks, R.E.

Biochem. Pharmacol.

30

189-199

637545

7732755

Substrate specificity of methylthioadenosine phosphorylase from human liver

1994

Fabianowska-Majewska, K.; Duley, J.; Fairbanks, L.; Simmonds, A.; Wasiak, T.

Acta Biochim. Pol.

41

391-395

640699

2844754

Purification and characterization of rhodopsin kinase

1988

Palczewski, K.; McDowell, J.H.; Hargrave, P.A.

J. Biol. Chem.

263

14067-14073

641083

6246102

Human placental adenosine kinase. Kinetic mechanism and inhibition

1980

Palella, T.D.; Andres, C.M.; Fox, I.H.

J. Biol. Chem.

255

5264-5269

645608

12482614

The PLP-dependent biotin synthase from Escherichia coli: mechanistic studies

2002

Ollagnier-de-Choudens, S.; Mulliez, E.; Fontecave, M.

FEBS Lett.

532

465-468

658283

15911263

Design, synthesis, and biological evaluation of novel human 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP) substrates

2005

Kung, P.P.; Zehnder, L.R.; Meng, J.J.; Kupchinsky, S.W.; Skalitzky, D.J.; Johnson, M.C.; Maegley, K.A.; Ekker, A.; Kuhn, L.A.; Rose, P.W.; Bloom, L.A.

Bioorg. Med. Chem. Lett.

15

2829-2833

675871

16879885

Adenosine kinase from Cryptosporidium parvum

2006

Galazka, J.; Striepen, B.; Ullman, B.

Mol. Biochem. Parasitol.

149

223-230

685030

18329005

Structure-activity relationship for adenosine kinase from Mycobacterium tuberculosis II. Modifications to the ribofuranosyl moiety

2008

Long, M.C.; Shaddix, S.C.; Moukha-Chafiq, O.; Maddry, J.A.; Nagy, L.; Parker, W.B.

Biochem. Pharmacol.

75

1588-1600

706428

19478948

Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategy

2009

Lubin, M.; Lubin, A.

PLoS ONE

4

e5735

708504

19328201

Product inhibition in the radical S-adenosylmethionine family

2009

Challand, M.R.; Ziegert, T.; Douglas, P.; Wood, R.J.; Kriek, M.; Shaw, N.M.; Roach, P.L.

FEBS Lett.

583

1358-1362

714225

20825170

Structure and mechanism of the 6-oxopurine nucleosidase from Trypanosoma brucei brucei

2010

Vandemeulebroucke, A.; Minici, C.; Bruno, I.; Muzzolini, L.; Tornaghi, P.; Parkin, D.W.; Versees, W.; Steyaert, J.; Degano, M.

Biochemistry

49

8999-9010

716263

21166890

Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism

2011

Parveen, N.; Cornell, K.A.

Mol. Microbiol.

79

7-20

716856

20954236

Enzyme-ligand interactions that drive active site rearrangements in the Helicobacter pylori 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase

2010

Ronning, D.R.; Iacopelli, N.M.; Mishra, V.

Protein Sci.

19

2498-2510

724296

20961145

Biotin synthase exhibits burst kinetics and multiple turnovers in the absence of inhibition by products and product-related biomolecules

2010

Farrar, C.E.; Siu, K.K.; Howell, P.L.; Jarrett, J.T.

Biochemistry

49

9985-9996

727008

23148563

Crystal structures of the Helicobacter pylori MTAN enzyme reveal specific interactions between S-adenosylhomocysteine and the 5-alkylthio binding subsite

2012

Mishra, V.; Ronning, D.R.

Biochemistry

51

9763-9772

727029

23972005

Deamination of 6-aminodeoxyfutalosine in menaquinone biosynthesis by distantly related enzymes

2013

Goble, A.M.; Toro, R.; Li, X.; Ornelas, A.; Fan, H.; Eswaramoorthy, S.; Patskovsky, Y.; Hillerich, B.; Seidel, R.; Sali, A.; Shoichet, B.K.; Almo, S.C.; Swaminathan, S.; Tanner, M.E.; Raushel, F.M.

Biochemistry

52

6525-6536

727637

23611628

Methylthioadenosine/S-adenosylhomocysteine nucleosidase (Pfs) of Staphylococcus aureus is essential for the virulence independent of LuxS/AI-2 system

2013

Bao, Y.; Li, Y.; Jiang, Q.; Zhao, L.; Xue, T.; Hu, B.; Sun, B.

Int. J. Med. Microbiol.

303

190-200

727779

24375099

Identification of a 5'-deoxyadenosine deaminase in Methanocaldococcus jannaschii and its possible role in recycling the radical S-adenosylmethionine enzyme reaction product 5'-deoxyadenosine

2013

Miller, D.; O'Brien, K.; Xu, H.; White, R.H.

J. Bacteriol.

196

1064-1072

727960

24014032

The thiamine biosynthetic enzyme ThiC catalyzes multiple turnovers and is inhibited by S-adenosylmethionine (AdoMet) metabolites

2013

Palmer, L.D.; Downs, D.M.

J. Biol. Chem.

288

30693-30699

749468

30339406

Transition-state analogues of Campylobacter jejuni 5'-methylthioadenosine nucleosidase

2018

Ducati, R.G.; Harijan, R.K.; Cameron, S.A.; Tyler, P.C.; Evans, G.B.; Schramm, V.L.

ACS Chem. Biol.

13

3173-3183

749468

30339406

Transition-state analogues of Campylobacter jejuni 5'-methylthioadenosine nucleosidase

2018

Ducati, R.G.; Harijan, R.K.; Cameron, S.A.; Tyler, P.C.; Evans, G.B.; Schramm, V.L.

ACS Chem. Biol.

13

3173-3183

751486

28487228

Characterization of S-adenosylhomocysteine/Methylthioadenosine nucleosidase on secretion of AI-2 and biofilm formation of Escherichia coli

2017

Han, T.; Li, Y.; Shan, Q.; Liang, W.; Hao, W.; Li, Y.; Tan, X.; Gu, J.

Microb. Pathog.

108

78-84

751486

28487228

Characterization of S-adenosylhomocysteine/Methylthioadenosine nucleosidase on secretion of AI-2 and biofilm formation of Escherichia coli

2017

Han, T.; Li, Y.; Shan, Q.; Liang, W.; Hao, W.; Li, Y.; Tan, X.; Gu, J.

Microb. Pathog.

108

78-84

758557

27019223

Transition state structure and inhibition of Rv0091, a 5'-deoxyadenosine/5'-methylthioadenosine nucleosidase from Mycobacterium tuberculosis

2016

Namanja-Magliano, H.A.; Stratton, C.F.; Schramm, V.L.

ACS Chem. Biol.

11

1669-1676

758557

27019223

Transition state structure and inhibition of Rv0091, a 5'-deoxyadenosine/5'-methylthioadenosine nucleosidase from Mycobacterium tuberculosis

2016

Namanja-Magliano, H.A.; Stratton, C.F.; Schramm, V.L.

ACS Chem. Biol.

11

1669-1676

759412

31381312

MftD catalyzes the formation of a biologically active redox center in the biosynthesis of the ribosomally synthesized and post-translationally modified redox cofactor mycofactocin

2019

Ayikpoe, R.; Latham, J.

J. Am. Chem. Soc.

141

13582-13591

759412

31381312

MftD catalyzes the formation of a biologically active redox center in the biosynthesis of the ribosomally synthesized and post-translationally modified redox cofactor mycofactocin

2019

Ayikpoe, R.; Latham, J.

J. Am. Chem. Soc.

141

13582-13591

749468

2 entries

751486

2 entries

758557

2 entries

759412

2 entries

760591

30183269

Mycofactocin biosynthesis proceeds through 3-amino-5-[( p-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidinone (AHDP); direct observation of MftE specificity toward MftA

2018

Ayikpoe, R.; Salazar, J.; Majestic, B.; Latham, J.A.

Biochemistry

57

5379-5383

760607

30628436

Spectroscopic and electrochemical characterization of the mycofactocin biosynthetic protein, MftC, provides insight into its redox flipping mechanism

2019

Ayikpoe, R.; Ngendahimana, T.; Langton, M.; Bonitatibus, S.; Walker, L.; Eaton, S.; Eaton, G.; Pandelia, M.; Elliott, S.; Latham, J.

Biochemistry

58

940-950

760607

30628436

Spectroscopic and electrochemical characterization of the mycofactocin biosynthetic protein, MftC, provides insight into its redox flipping mechanism

2019

Ayikpoe, R.; Ngendahimana, T.; Langton, M.; Bonitatibus, S.; Walker, L.; Eaton, S.; Eaton, G.; Pandelia, M.; Elliott, S.; Latham, J.

Biochemistry

58

940-950

762502

27156617

Cloning, expression and characterization of histidine-tagged biotin synthase of Mycobacterium tuberculosis

2016

Magwamba, C.C.; Rukseree, K.; Palittapongarnpim, P.

Tuberculosis

98

42-49

762502

27156617

Cloning, expression and characterization of histidine-tagged biotin synthase of Mycobacterium tuberculosis

2016

Magwamba, C.C.; Rukseree, K.; Palittapongarnpim, P.

Tuberculosis

98

42-49

760607

2 entries

762502

2 entries

769274

31669585

Characterization of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases from Borrelia burgdorferi Antibiotic targets for Lyme disease

2020

Cornell, K.A.; Knippel, R.J.; Cortright, G.R.; Fonken, M.; Guerrero, C.; Hall, A.R.; Mitchell, K.A.; Thurston, J.H.; Erstad, P.; Tao, A.; Xu, D.; Parveen, N.

Biochim. Biophys. Acta Gen. Subj.

1864

129455

773918

31113891

Mycofactocin is associated with ethanol metabolism in mycobacteria

2019

Krishnamoorthy, G.; Kaiser, P.; Lozza, L.; Hahnke, K.; Mollenkopf, H.; Kaufmann, S.

mBio

10

e00190-19