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TaxTree of Organism Ixodes scapularis
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PATHWAY 
BRENDA Link
KEGG Link
MetaCyc Link
(R)-cysteate degradation
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PWY-6642
(S)-lactate fermentation to propanoate, acetate and hydrogen
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PWY-8086
(S)-reticuline biosynthesis I
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PWY-3581
1,5-anhydrofructose degradation
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PWY-6992
1-butanol autotrophic biosynthesis (engineered)
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PWY-6886
2-arachidonoylglycerol biosynthesis
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PWY-8052
3-(4-hydroxyphenyl)pyruvate biosynthesis
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PWY-5886
3-hydroxy-4-methyl-anthranilate biosynthesis I
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PWY-7717
3-hydroxy-4-methyl-anthranilate biosynthesis II
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PWY-7765
3-phosphoinositide biosynthesis
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PWY-6352
4-hydroxy-2-nonenal detoxification
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PWY-7112
4-hydroxybenzoate biosynthesis I (eukaryotes)
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PWY-5754
5-oxo-L-proline metabolism
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PWY-7942
acetaldehyde biosynthesis II
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PWY-6330
acetone degradation I (to methylglyoxal)
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PWY-5451
acetone degradation III (to propane-1,2-diol)
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PWY-7466
acrylonitrile degradation I
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PWY-7308
adenosine nucleotides degradation I
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PWY-6596
adenosine nucleotides degradation II
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SALVADEHYPOX-PWY
aerobic respiration I (cytochrome c)
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PWY-3781
aerobic respiration II (cytochrome c) (yeast)
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PWY-7279
aldoxime degradation
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P345-PWY
all-trans-farnesol biosynthesis
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PWY-6859
alpha-linolenate metabolites biosynthesis
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PWY-8398
Amaryllidacea alkaloids biosynthesis
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PWY-7826
ammonia oxidation II (anaerobic)
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P303-PWY
anaerobic energy metabolism (invertebrates, cytosol)
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PWY-7383
anandamide biosynthesis I
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PWY-8051
anandamide biosynthesis II
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PWY-8053
arachidonate metabolites biosynthesis
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PWY-8397
arsenic detoxification (plants)
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PWY-8259
arsenic detoxification (yeast)
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PWY-4621
arsenite to oxygen electron transfer
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PWY-4521
arsenite to oxygen electron transfer (via azurin)
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PWY-7429
ascorbate recycling (cytosolic)
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PWY-6370
aspirin triggered resolvin D biosynthesis
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PWY66-395
aspirin triggered resolvin E biosynthesis
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PWY66-394
ATP biosynthesis
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PWY-7980
atromentin biosynthesis
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PWY-7518
bacterial bioluminescence
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PWY-7723
beta-D-glucuronide and D-glucuronate degradation
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PWY-7247
Bifidobacterium shunt
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P124-PWY
bisabolene biosynthesis (engineered)
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PWY-7102
bupropion degradation
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PWY66-241
butanol and isobutanol biosynthesis (engineered)
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PWY-7396
C4 photosynthetic carbon assimilation cycle, NAD-ME type
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PWY-7115
C4 photosynthetic carbon assimilation cycle, NADP-ME type
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PWY-241
C4 photosynthetic carbon assimilation cycle, PEPCK type
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PWY-7117
caffeine degradation III (bacteria, via demethylation)
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PWY-6538
Calvin-Benson-Bassham cycle
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CALVIN-PWY
camalexin biosynthesis
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CAMALEXIN-SYN
chitin biosynthesis
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PWY-6981
chitin deacetylation
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PWY-7118
chitin degradation I (archaea)
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PWY-6855
chitin degradation II (Vibrio)
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PWY-6902
chitin degradation III (Serratia)
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PWY-7822
cis-zeatin biosynthesis
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PWY-2781
CO2 fixation into oxaloacetate (anaplerotic)
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PWYQT-4429
coenzyme M biosynthesis II
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PWY-6643
cytosolic NADPH production (yeast)
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PWY-7268
degradation of aromatic, nitrogen containing compounds
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di-homo-gamma-linolenate metabolites biosynthesis
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PWY-8396
diethylphosphate degradation
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PWY-5491
docosahexaenoate metabolites biosynthesis
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PWY-8400
dopamine degradation
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PWY6666-2
drosopterin and aurodrosopterin biosynthesis
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PWY-7442
Entner-Doudoroff pathway I
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PWY-8004
Entner-Doudoroff pathway II (non-phosphorylative)
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NPGLUCAT-PWY
Entner-Doudoroff pathway III (semi-phosphorylative)
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PWY-2221
erythro-tetrahydrobiopterin biosynthesis I
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PWY-5663
ethanol degradation IV
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PWY66-162
ethene biosynthesis III (microbes)
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PWY-6854
ethene biosynthesis V (engineered)
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PWY-7124
Fe(II) oxidation
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PWY-6692
formaldehyde assimilation I (serine pathway)
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PWY-1622
formaldehyde assimilation III (dihydroxyacetone cycle)
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P185-PWY
formaldehyde oxidation I
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RUMP-PWY
gliotoxin biosynthesis
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PWY-7533
gluconeogenesis I
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GLUCONEO-PWY
gluconeogenesis II (Methanobacterium thermoautotrophicum)
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PWY-6142
gluconeogenesis III
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PWY66-399
glucosinolate biosynthesis from dihomomethionine
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PWYQT-4471
glucosinolate biosynthesis from hexahomomethionine
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PWYQT-4475
glucosinolate biosynthesis from homomethionine
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PWY-1187
glucosinolate biosynthesis from pentahomomethionine
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PWYQT-4474
glucosinolate biosynthesis from phenylalanine
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PWY-2821
glucosinolate biosynthesis from tetrahomomethionine
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PWYQT-4473
glucosinolate biosynthesis from trihomomethionine
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PWYQT-4472
glucosinolate biosynthesis from tryptophan
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PWY-601
glucosinolate biosynthesis from tyrosine
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PWY-7901
glutathione-mediated detoxification I
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PWY-4061
glutathione-mediated detoxification II
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PWY-6842
glutathione-peroxide redox reactions
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PWY-4081
glycerol degradation to butanol
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PWY-7003
glycolysis I (from glucose 6-phosphate)
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GLYCOLYSIS
glycolysis II (from fructose 6-phosphate)
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PWY-5484
glycolysis III (from glucose)
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ANAGLYCOLYSIS-PWY
glycolysis IV
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PWY-1042
glycolysis V (Pyrococcus)
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P341-PWY
glyoxylate cycle
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GLYOXYLATE-BYPASS
guanosine nucleotides degradation I
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PWY-6607
guanosine nucleotides degradation II
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PWY-6606
guanosine nucleotides degradation III
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PWY-6608
heterolactic fermentation
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P122-PWY
homocysteine and cysteine interconversion
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PWY-801
icosapentaenoate metabolites biosynthesis
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PWY-8399
incomplete reductive TCA cycle
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P42-PWY
indole glucosinolate activation (intact plant cell)
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PWYQT-4477
indole-3-acetate biosynthesis II
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PWY-581
indole-3-acetate biosynthesis III (bacteria)
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PWY-3161
indole-3-acetate biosynthesis IV (bacteria)
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PWY-5025
indole-3-acetate biosynthesis VI (bacteria)
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TRPIAACAT-PWY
inosine 5'-phosphate degradation
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PWY-5695
isoprene biosynthesis II (engineered)
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PWY-7391
juvenile hormone III biosynthesis I
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PWY-6575
juvenile hormone III biosynthesis II
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PWY-6650
L-arginine degradation X (arginine monooxygenase pathway)
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ARGDEG-V-PWY
L-asparagine degradation III (mammalian)
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ASPARAGINE-DEG1-PWY-1
L-aspartate biosynthesis
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ASPARTATESYN-PWY
L-aspartate degradation I
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ASPARTATE-DEG1-PWY
L-glutamate degradation II
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GLUTDEG-PWY
L-histidine degradation V
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PWY-5031
L-methionine biosynthesis I
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HOMOSER-METSYN-PWY
L-methionine degradation III
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PWY-5082
L-phenylalanine biosynthesis I
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PHESYN
L-phenylalanine degradation II (anaerobic)
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ANAPHENOXI-PWY
L-phenylalanine degradation III
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PWY-5079
L-phenylalanine degradation IV (mammalian, via side chain)
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PWY-6318
L-phenylalanine degradation VI (reductive Stickland reaction)
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PWY-8014
L-tryptophan degradation I (via anthranilate)
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TRPCAT-PWY
L-tryptophan degradation IV (via indole-3-lactate)
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TRPKYNCAT-PWY
L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
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PWY-5651
L-tryptophan degradation VIII (to tryptophol)
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PWY-5081
L-tryptophan degradation XI (mammalian, via kynurenine)
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PWY-6309
L-tryptophan degradation XIII (reductive Stickland reaction)
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PWY-8017
L-tyrosine biosynthesis I
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TYRSYN
L-tyrosine degradation I
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TYRFUMCAT-PWY
L-tyrosine degradation II
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PWY-5151
L-tyrosine degradation III
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PWY3O-4108
L-tyrosine degradation IV (to 4-methylphenol)
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PWY-7514
L-tyrosine degradation V (reductive Stickland reaction)
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PWY-8016
lanosterol biosynthesis
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PWY-6132
linoleate metabolites biosynthesis
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PWY-8395
long chain fatty acid ester synthesis (engineered)
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PWY-6873
luteolin triglucuronide degradation
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PWY-7445
malate/L-aspartate shuttle pathway
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MALATE-ASPARTATE-SHUTTLE-PWY
maresin biosynthesis
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PWY-8356
melatonin degradation I
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PWY-6398
melibiose degradation
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PWY0-1301
Methanobacterium thermoautotrophicum biosynthetic metabolism
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PWY-6146
methanol oxidation to formaldehyde IV
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PWY-5506
methyl indole-3-acetate interconversion
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PWY-6303
methyl phomopsenoate biosynthesis
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PWY-7721
methylaspartate cycle
methylsalicylate degradation
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PWY18C3-24
mevalonate pathway I (eukaryotes and bacteria)
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PWY-922
mevalonate pathway II (haloarchaea)
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PWY-6174
mevalonate pathway IV (archaea)
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PWY-8125
mixed acid fermentation
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FERMENTATION-PWY
NAD salvage (plants)
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PWY-5381
NAD salvage pathway I (PNC VI cycle)
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PYRIDNUCSAL-PWY
NAD salvage pathway III (to nicotinamide riboside)
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NAD-BIOSYNTHESIS-II
NAD salvage pathway V (PNC V cycle)
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PWY3O-4107
NADPH to cytochrome c oxidase via plastocyanin
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PWY-8271
nicotine degradation IV
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PWY66-201
nicotine degradation V
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PWY66-221
nitrate reduction I (denitrification)
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DENITRIFICATION-PWY
nitrate reduction VII (denitrification)
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PWY-6748
nitrifier denitrification
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PWY-7084
nitrite-dependent anaerobic methane oxidation
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PWY-6523
nitrogen remobilization from senescing leaves
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PWY-6549
nocardicin A biosynthesis
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PWY-7797
o-diquinones biosynthesis
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PWY-6752
partial TCA cycle (obligate autotrophs)
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PWY-5913
pentachlorophenol degradation
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PCPDEG-PWY
pentose phosphate pathway (oxidative branch) I
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OXIDATIVEPENT-PWY
peptido-conjugates in tissue regeneration biosynthesis
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PWY-8355
phosphatidylcholine acyl editing
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PWY-6803
phosphatidylcholine resynthesis via glycerophosphocholine
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PWY-7367
phospholipases
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LIPASYN-PWY
phospholipid remodeling (phosphatidate, yeast)
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PWY-7417
phospholipid remodeling (phosphatidylcholine, yeast)
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PWY-7416
phospholipid remodeling (phosphatidylethanolamine, yeast)
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PWY-7409
phosphopantothenate biosynthesis I
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PANTO-PWY
photosynthetic 3-hydroxybutanoate biosynthesis (engineered)
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PWY-7218
plasmalogen biosynthesis I (aerobic)
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PWY-7782
plasmalogen degradation
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PWY-7783
protectin biosynthesis
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PWY-8357
protein ubiquitination
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PWY-7511
pyruvate fermentation to (S)-lactate
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PWY-5481
pyruvate fermentation to acetate VIII
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PWY-5768
pyruvate fermentation to acetoin III
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PWY3O-440
pyruvate fermentation to ethanol II
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PWY-5486
pyruvate fermentation to propanoate I
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P108-PWY
reactive oxygen species degradation
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DETOX1-PWY-1
reductive TCA cycle I
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P23-PWY
reductive TCA cycle II
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PWY-5392
resolvin D biosynthesis
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PWY66-397
retinol biosynthesis
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PWY-6857
rosmarinic acid biosynthesis I
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-
PWY-5048
Rubisco shunt
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PWY-5723
S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine biosynthesis
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PWY-8301
S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine degradation
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PWY-8302
seleno-amino acid biosynthesis (plants)
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PWY-6936
serotonin degradation
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PWY-6313
spermidine biosynthesis I
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BSUBPOLYAMSYN-PWY
sphingolipid biosynthesis (mammals)
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PWY-7277
sphingomyelin metabolism
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PWY3DJ-11281
stachyose degradation
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PWY-6527
stellatic acid biosynthesis
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PWY-7736
succinate to chytochrome c oxidase via cytochrome c6
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PWY1YI0-2
succinate to cytochrome c oxidase via plastocyanin
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PWY1YI0-3
sucrose biosynthesis I (from photosynthesis)
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SUCSYN-PWY
sulfolactate degradation III
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PWY-6638
superoxide radicals degradation
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DETOX1-PWY
superpathway of glucose and xylose degradation
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PWY-6901
superpathway of glycolysis and the Entner-Doudoroff pathway
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GLYCOLYSIS-E-D
superpathway of glyoxylate cycle and fatty acid degradation
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PWY-561
superpathway of methylsalicylate metabolism
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PWY18C3-25
TCA cycle I (prokaryotic)
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TCA
TCA cycle II (plants and fungi)
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PWY-5690
TCA cycle III (animals)
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PWY66-398
TCA cycle IV (2-oxoglutarate decarboxylase)
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P105-PWY
TCA cycle V (2-oxoglutarate synthase)
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PWY-6969
TCA cycle VI (Helicobacter)
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REDCITCYC
TCA cycle VII (acetate-producers)
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PWY-7254
TCA cycle VIII (Chlamydia)
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TCA-1
theophylline degradation
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PWY-6999
threo-tetrahydrobiopterin biosynthesis
-
-
PWY-6983
thyroid hormone metabolism II (via conjugation and/or degradation)
-
-
PWY-6261
trans, trans-farnesyl diphosphate biosynthesis
-
-
PWY-5123
tRNA processing
-
-
PWY0-1479
tunicamycin biosynthesis
-
-
PWY-7821
UTP and CTP dephosphorylation I
-
-
PWY-7185
UTP and CTP dephosphorylation II
-
-
PWY-7177
vanillin biosynthesis I
-
-
PWY-5665
methylaspartate cycle
-
-
PWY-6728
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ORGANISM
COMMENTARY 
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
exclusively expressed in the gut tissue. IsAE1 is the principle legumain transcript in partially engorged females, and demonstrates its strong regulation by on-host feeding in larvae, nymphs and females. IsAE1 is the most highly expressed gut-specific legumain in blood fed ticks where it predominated over all its paralogues
IsAE2 is the predominant gut legumain in unfed nymphs, unfed females and males
LINKS TO OTHER DATABASES (specific for Ixodes scapularis)
SILVA: 16S/18S rRNA, 23S/28S rRNA
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Release 2023.1 (January 2023)
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