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Literature summary extracted from

  • Adamson, S.W.; Browning, R.E.; Chao, C.C.; Bateman, R.C.; Ching, W.M.; Karim, S.
    Molecular characterization of tick salivary gland glutaminyl cyclase (2013), Insect Biochem. Mol. Biol., 43, 781-793.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.2.5 Zn2+ contains zinc Ixodes scapularis
2.3.2.5 Zn2+ contains zinc Amblyomma maculatum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.5 L-glutaminyl-peptide Ixodes scapularis
-
 5-oxoprolyl-peptide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide Amblyomma maculatum
-
 5-oxoprolyl-peptide + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.5 Amblyomma maculatum G3MGU0
-
-
2.3.2.5 Ixodes scapularis B7QK46
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.5 saliva
-
 Ixodes scapularis
-
2.3.2.5 saliva
-
 Amblyomma maculatum
-
2.3.2.5 salivary gland
-
 Ixodes scapularis
-
2.3.2.5 salivary gland
-
 Amblyomma maculatum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.5 L-Glu-2-naphthylamide
-
 Ixodes scapularis 5-oxo-L-prolyl-2-naphthylamide + NH3
-
 ?
2.3.2.5 L-Glu-2-naphthylamide
-
 Amblyomma maculatum 5-oxo-L-prolyl-2-naphthylamide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide
-
 Ixodes scapularis 5-oxoprolyl-peptide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide
-
 Amblyomma maculatum 5-oxoprolyl-peptide + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.5 glutaminyl cyclase
-
 Ixodes scapularis
2.3.2.5 glutaminyl cyclase
-
 Amblyomma maculatum

Expression

EC Number Organism Comment Expression
2.3.2.5 Ixodes scapularis the enzyme is upregulated during the bloodmeal up
2.3.2.5 Amblyomma maculatum the enzyme is upregulated during the bloodmeal up

General Information

EC Number General Information Comment Organism
2.3.2.5 malfunction knockdown of enzyme-transcript results in lower enzymatic activity, and small, unviable egg masses Ixodes scapularis
2.3.2.5 malfunction knockdown of enzyme-transcript results in lower enzymatic activity, and small, unviable egg masses Amblyomma maculatum